The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
Citations
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A novel and automated assay for thiol/disulphide homeostasis.
Ozcan Erel,Salim Neselioglu +1 more
TL;DR: In this paper, the authors developed a novel and automated assay determining plasma thiol/disulphide homeostasis, which consists of thiol-disoulphide exchanges.
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Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits.
TL;DR: A key conclusion is a reinforcement of the concept that NAC should not be considered to be a powerful antioxidant in its own right: its strength is the targeted replenishment of GSH in deficient cells and it is likely to be ineffective in cells replete in GSH.
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N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why
Giancarlo Aldini,Alessandra Altomare,Giovanna Baron,Giulio Vistoli,Marina Carini,Luisa Borsani,Francesco Sergio +6 more
TL;DR: The disulphide breaking activity of NAC also explains its mucolytic activity which is due to its effect in reducing heavily cross-linked mucus glycoproteins and free thiols as well as reduced proteins which have important direct antioxidant activity.
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Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications
TL;DR: A comprehensive overview of the key sequences and structures utilised to provide biological and physical stability to nano-constructs, direct particles to their target and influence their cellular and tissue distribution, induce and control biological responses, and form polypeptide self-assembled nanoparticles are provided.
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The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine.
Miriam M. Cortese-Krott,Anne M. Koning,Gunter G. C. Kuhnle,Péter Nagy,Christopher L. Bianco,Christopher L. Bianco,Andreas Pasch,David A. Wink,Jon M. Fukuto,Jon M. Fukuto,Jon M. Fukuto,Alan Jackson,Harry van Goor,Kenneth R. Olson,Martin Feelisch +14 more
TL;DR: This work introduces a novel integrative concept defined as the reactive species interactome (RSI), a primeval multilevel redox regulatory system whose architecture allows efficient sensing and rapid adaptation to environmental changes and various other stressors to enhance fitness and resilience at the local and whole-organism level.
References
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Tissue sites of catabolism of albumin in rabbits.
TL;DR: Expressed in terms of activity per unit wet weight, adrenal, kidney, spleen, ovary, bone marrow, and liver were the most active tissues, suggesting that exposure to high concentrations of albumin is an important determinant of their high rates ofalbumin degradation.
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Characterization of oxidation end product of plasma albumin 'in vivo'.
Luca Musante,Maurizio Bruschi,Giovanni Candiano,Andrea Petretto,Nazzareno Dimasi,Piero Del Boccio,Andrea Urbani,Giovanni Rialdi,Gian Marco Ghiggeri +8 more
TL;DR: It is demonstrated by LC/MS/MS that plasma albumin undergoes massive oxidation in primary nephrotic syndrome, involving stable sulphonation SO3- of the free SH of Cys 34 with +48Da increase in exact mass of the protein (ESI-MS) and formation of a fast moving isoform in the pH range between 5 and 7.
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The undertow of sulfur metabolism on glutamatergic neurotransmission.
TL;DR: It is proposed that underlying waves of glutamate clearance by astrocytes are activation of cystine import and taurine efflux that result, respectively, from a shared transporter and an increase in solute concentration that triggers osmoregulatory responses.
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Albumin turnover: experimental approach and its application in health and renal diseases.
TL;DR: This review highlights several studies over the past years that have contributed to knowledge of albumin metabolism and an overview on how to measure albumin turnover including a general approach is given.
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Observation for redox state of human serum and aqueous humor albumin from patients with senile cataract
TL;DR: It is anticipated that significantly decreased f(HMA) and increased f (HNA) values in aqueous humor from patients with senile cataract may clearly reflect defective antioxidative defense systems which may lead to the formation of aCataract.