The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters.
Fadime Gullu Haydar,Yavuz Otal,Alp Şener,Gul Pamukcu Gunaydin,Ferhat Icme,Tuğba Atmaca Temrel,Pervin Baran,Ozcan Erel +7 more
TL;DR: The disruption of the thiol-disulfide balance may play a role in the pathogenesis of acute pancreatitis and administration of the complementary therapies for this thiol deficiency may contribute to the treatment of the disease.
Journal ArticleDOI
Biomonitoring of Ambient Outdoor Air Pollutant Exposure in Humans Using Targeted Serum Albumin Adductomics.
Joshua W. Smith,Robert N. O'Meally,Derek K. Ng,Jianguo Chen,Thomas W. Kensler,Thomas W. Kensler,Robert N. Cole,John D. Groopman +7 more
TL;DR: In this article, a targeted albumin adductomics platform was developed and validated to simultaneously monitor dozens of Cys34 adducts per sample in only 2.5 μL of serum, with on-column limits of detection in the low femtomolar range.
Journal ArticleDOI
Maternal and fetal thiol/disulfide homeostasis in fetal growth restriction.
TL;DR: Maternal and fetal serum thiol/disulfide profiles may use prediction of FGR severity and its neonatal outcome to improve homeostasis in both maternal and fetal compartment in the presence of fetal growth restriction.
Journal ArticleDOI
A novel marker in acute central serous chorioretinopathy: thiol/disulfide homeostasis.
Hasan Altinkaynak,Piraye Zeynep Kurkcuoglu,Mehtap Caglayan,Mücella Arıkan Yorgun,Nilay Yuksel,Pinar Kosekahya,Cemile Koca,Yasin Toklu +7 more
TL;DR: Comparing dynamic thiol/disulfide homeostatic status in acute central serous chorioretinopathy (CSCR) patients by using a novel and automated assay determining dynamicThiol/DisulfideHomeostasis showed lower values in patients with acute CSCR when compared with healthy controls.
Journal ArticleDOI
Redox Imbalance and Methylation Disturbances in Early Childhood Obesity
Pedro Barbosa,Stepan Melnyk,Sirish C. Bennuri,Leanna Delhey,Andreia Reis,Gabriela Moura,Elisabet Børsheim,Shannon Rose,Eugenia Carvalho +8 more
TL;DR: In this article, the authors tested the hypothesis that one-carbon metabolism is already dysregulated in prepubertal children with obesity and found that Sulfur-containing amino acids, methionine, cysteine, and their derivatives play important roles in the transmethylation and transsulfuration pathways.
References
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Bilirubin is an antioxidant of possible physiological importance
TL;DR: The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
Journal ArticleDOI
Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
Journal ArticleDOI
Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.