The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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Reversible Self-Assembly of Nanoprobes in Live Cells for Dynamic Intracellular pH Imaging
Bo Dong,Shuangli Du,Chunxiao Wang,Haohao Fu,Qiang Li,Nannan Xiao,Jie Yang,Xue Xue,Wensheng Cai,Dingbin Liu +9 more
TL;DR: A robust reversible self-assembly system that is composed of a hydrophobic gold nanoparticle (AuNP) core and a shell of pH-responsive dye-incorporated block copolymers, supported by free-energy calculations to facilitate the study of pH influence on biological processes is described.
Journal ArticleDOI
Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum.
TL;DR: Native and total thiol were deficient in the hyperemesis gravidarum group and this deficiency was correlated with the severity of the disease, indicating the thiol-disulfide balance has shifted to the oxidative side.
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Conjugate of Doxorubicin to Albumin-Binding Peptide Outperforms Aldoxorubicin
Parisa Yousefpour,Lucie Ahn,Joel Tewksbury,Soumen Saha,Simone A. Costa,Joseph J. Bellucci,Xinghai Li,Ashutosh Chilkoti +7 more
TL;DR: Improved pharmacokinetics and biodistribution of ABD-Dox result in enhanced therapeutic efficacy in syngeneic C26 colon carcinoma and MIA PaCa-2 pancreatic tumor xenografts, compared with free Dox and aldoxorubicin, an albumin-reactive Dox prodrug currently in clinical development.
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Nitro-Fatty Acid Logistics: Formation, Biodistribution, Signaling, and Pharmacology.
TL;DR: This review focuses on the endogenously formed NO2-FAs' mechanism of absorption, systemic distribution, signaling, and preclinical models to facilitate targeted dietary interventions and further the current pharmacological development aimed at low-grade inflammatory diseases.
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Disulfide bond generation in mammalian blood serum: detection and purification of quiescin-sulfhydryl oxidase
TL;DR: Recent proteomic studies showing that plasma QSOX1 can be utilized in the diagnosis of pancreatic cancer and acute decompensated heart failure, together with the overexpression of this secreted enzyme in a number of solid tumors, suggest that the robust QSOZ assay developed here may be useful in the quantitation of enzyme levels in a wide range of biological fluids.
References
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Journal ArticleDOI
Bilirubin is an antioxidant of possible physiological importance
TL;DR: The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
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Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
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Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.