The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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The effects of ozone on bacterial growth and thiol-disulphide homeostasis in vascular graft infection caused by MRSA in rats.
Barcin Ozturk,Tünay Kurtoğlu,Selim Durmaz,Leyla Didem Kozaci,Filiz Abacigil,Bulent Ertugrul,Ozcan Erel +6 more
TL;DR: Effects of ozone on thiol-disulphide homeostasis and inflammatory cytokines were contradictory and didn't observe any benefit of the agent on MRSA elimination in the authors' model.
Journal ArticleDOI
Oxidative Stress Markers Patients with Parotid Gland Tumors: A Pilot Study.
Paweł Sowa,Maciej Misiołek,Bartlomiej Pasinski,Grzegorz Bartosz,Mirosław Soszyński,Monika Adamczyk-Sowa,Izabela Sadowska-Bartosz +6 more
TL;DR: The data indicate the occurrence of OS in patients with parotid gland tumors and point to various sensitivities of OS markers.
Journal ArticleDOI
Platelet-Inspired Intravenous Nanomedicine for Injury-Targeted Direct Delivery of Thrombin to Augment Hemostasis in Coagulopathies.
Aditya Girish,K. Jolly,Nijmeh Alsaadi,María Carolina Silva-de la Fuente,Arielle Recchione,Ran An,Dante Disharoon,Zachary Secunda,S. Raghunathan,Norman Luc,Cian Desai,Elizabeth A. Knauss,Xu Han,Keren Hu,Han Yen Wang,Ujjal D. S. Sekhon,Nathan A. Rohner,Umut A. Gurkan,Marvin T. Nieman,Matthew D. Neal,Anirban Sen Gupta +20 more
TL;DR: The designs and evaluation of thrombin-loaded injury-site-targeted lipid nanoparticles (t-TLNPs) that can specifically localize at an injury site via platelet-mimetic anchorage to the von Willebrand factor (vWF) and collagen and directly releaseThrombin via diffusion and phospholipase-triggered particle destabilization can restore fibrin in hemostatic dysfunction settings.
Journal ArticleDOI
Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome.
Ayca Tuzcu,Rabia Aydogan Baykara,Murat Alisik,Ahmet Omma,Gunseli Karaca Acet,Erdal Dogan,Medine Cumhur Cure,Fatih Duygun,Erkan Cure,Ozcan Erel +9 more
TL;DR: It is determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.
References
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Bilirubin is an antioxidant of possible physiological importance
TL;DR: The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
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All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
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Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
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Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.