The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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Determination of thiol/disulphide homeostasis as a new indicator of oxidative stress in dairy cows with subclinical endometritis
Birten Emre,Ömer Korkmaz,Ismail Koyuncu,Selim Çomaklı,Aytaç Akçay,Abuzer Kafar Zonturlu,Ozcan Erel +6 more
TL;DR: In this article, the authors used the Giemsa method and immunocytochemical staining to determine chronic inflammation and activity status of infertile cows with subclinical endometritis.
Journal ArticleDOI
Alterations in conformational state of albumin in plasma in chronic hemodialyzed patients
TL;DR: The results show that albumin from CH patients is highly modified in vivo and is not vulnerable to oxidation in the same way as normal albumin.
Journal ArticleDOI
Selecting heart failure patients for metabolic interventions
TL;DR: Meticulous patient-selection with molecular imaging techniques and specific biomarkers appears indispensable for the effective translation of decades of scientific knowledge into clinical therapeutics.
Journal ArticleDOI
Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles.
Brian R. Hearn,Shaun D. Fontaine,Eric L. Schneider,Yannick Kraemer,Gary W. Ashley,Daniel V. Santi +5 more
TL;DR: In this paper, the authors developed linkers that have predictable rates of β-elimination but suppressed rates of nucleophilic addition to their Michael acceptor products, which can potentially react with biological amines and thiols.
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Investigation of dynamic thiol-disulphide homoeostasis in age-related cataract patients with a novel and automated assay.
Hacı Murat Sağdık,Fatma Uçar,Mehmet Tetikoğlu,Serdar Aktas,Fatih Özcura,Havva Kocak,Salim Neselioglu,Funda Eren +7 more
TL;DR: The study showed that dynamic thiol–disulphide homoeostasis has shifted towards disulphides formation, as a result of thiol oxidation in ARC patients, which supports the hypothesis that cataract is an oxidative disorder.
References
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Bilirubin is an antioxidant of possible physiological importance
TL;DR: The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
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Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
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Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.