The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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Interfacial cationization to quicken redox-responsive drug release
TL;DR: Interfacial cationization could greatly increase the redox-responsiveness of disulfide bond-linked lipid-drug nanoassemblies (NAs) due to the generation and concentration of ionized thiols at the alkalized NAs' cationic interface.
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Thiol/disulfide homeostasis in patients with ocular-active and ocular-inactive Behçet disease
TL;DR: Thiol oxidation in BD patients resulted in a change of the thiol/disulfide balance, which can be used an innovative oxidative stress marker in patients with Behçet disease.
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A remarkable point for evaluating the severity of burns: Thiol-disulfide profile.
TL;DR: It is provided that thiol-disulfide homeostasis might be a notable key for evaluating the severity of burns and predicting the survival in patients suffering from burn injuries.
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Gold-activated luminol chemiluminescence for the selective determination of cysteine over homocysteine and glutathione.
Elli A. Akrivi,Athanasios G. Vlessidis,Nikolaos Kourkoumelis,Dimosthenis L. Giokas,George Z. Tsogas +4 more
TL;DR: In this article , a method based on the ability of cysteine to selectively enhance the metal-catalyzed chemiluminescence generated by the oxidation of luminol from gold tetrachloride anions under alkaline conditions was proposed.
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Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?
W.A. Sepúlveda Loyola,F. Vilaça Cavallari Machado,L. Araújo de Castro,T. Hissnauer Leal Baltus,N. Rampazzo Morelli,K. Landucci Bonifácio,A.A. Morita,Ana Paula Michelin,D. Sabbatini Barbosa,V.S. Probst +9 more
TL;DR: COPD severity, worse pulmonary function and presence of metabolic syndrome are associated with oxidative stress in individuals with COPD.
References
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Bilirubin is an antioxidant of possible physiological importance
TL;DR: The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
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Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
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Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.