The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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The Disposal of Reactive Carbonyl Species through Carnosine Conjugation: What We Know Now.
Ettore Gilardoni,Giovanna Baron,Alessandra Altomare,Marina Carini,Giancarlo Aldini,Luca Regazzoni +5 more
TL;DR: Current knowledge of the binding of reactive carbonyl species with Carnosine together with the disposal of carnosine conjugates is reviewed, emphasizing those aspects still requiring investigation such as conjugation reversibility and enzyme assisted catalysis of the reactions.
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Thiol/disulfide homeostasis in postmenopausal osteoporosis.
Vakkas Korkmaz,Zehra Kurdoglu,Murat Alisik,E Turgut,O O Sezgın,Hilal Korkmaz,Yusuf Ergün,Ozcan Erel +7 more
TL;DR: Thiol/disulfide homeostasis shifted to the disulfide side independent of age and years since menopause in postmenopausal osteoporosis.
Journal ArticleDOI
Quantitative Redox Biology of Exercise.
TL;DR: This work explains the basic chemical kinetics concepts and algebraic equations required to perform "street fighting" quantitative analysis of redox biology and presents the quantitative effect of exercise on superoxide, hydrogen peroxide and nitric oxide concentration in mitochondria and whole muscle.
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Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia.
Fatma Fidan,Berat Meryem Alkan,Fatma Gülçin Uğurlu,Sinem Bozkurt,Nebahat Sezer,Cemile Biçer,Ozcan Erel,Özge Ardiçoğlu,Selami Akkuş +8 more
TL;DR: Because of the decreased disulphide and increased native thiol levels, the thiol/disulphides balance has shifted to the reductive side and this metabolic disturbance may have a role in the pathogenesis of FMS.
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Evaluation of dynamic thiol-disulfide homeostasis in glaucoma patients and the correlation with retinal nerve fiber layer analysis.
TL;DR: The findings have reinforced the role of oxidative stress in the etiopathogenesis of primary open-angle glaucoma, suggesting that the thinning retinal nerve fiber layer may be associated with oxidative Stress in favor of prooxidant shift.
References
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Journal ArticleDOI
Bilirubin is an antioxidant of possible physiological importance
TL;DR: The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
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Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
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Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.