The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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A novel and automated assay for thiol/disulphide homeostasis.
Ozcan Erel,Salim Neselioglu +1 more
TL;DR: In this paper, the authors developed a novel and automated assay determining plasma thiol/disulphide homeostasis, which consists of thiol-disoulphide exchanges.
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Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits.
TL;DR: A key conclusion is a reinforcement of the concept that NAC should not be considered to be a powerful antioxidant in its own right: its strength is the targeted replenishment of GSH in deficient cells and it is likely to be ineffective in cells replete in GSH.
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N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why
Giancarlo Aldini,Alessandra Altomare,Giovanna Baron,Giulio Vistoli,Marina Carini,Luisa Borsani,Francesco Sergio +6 more
TL;DR: The disulphide breaking activity of NAC also explains its mucolytic activity which is due to its effect in reducing heavily cross-linked mucus glycoproteins and free thiols as well as reduced proteins which have important direct antioxidant activity.
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Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications
TL;DR: A comprehensive overview of the key sequences and structures utilised to provide biological and physical stability to nano-constructs, direct particles to their target and influence their cellular and tissue distribution, induce and control biological responses, and form polypeptide self-assembled nanoparticles are provided.
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The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine.
Miriam M. Cortese-Krott,Anne M. Koning,Gunter G. C. Kuhnle,Péter Nagy,Christopher L. Bianco,Christopher L. Bianco,Andreas Pasch,David A. Wink,Jon M. Fukuto,Jon M. Fukuto,Jon M. Fukuto,Alan Jackson,Harry van Goor,Kenneth R. Olson,Martin Feelisch +14 more
TL;DR: This work introduces a novel integrative concept defined as the reactive species interactome (RSI), a primeval multilevel redox regulatory system whose architecture allows efficient sensing and rapid adaptation to environmental changes and various other stressors to enhance fitness and resilience at the local and whole-organism level.
References
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Cysteine/cystine redox signaling in cardiovascular disease
Young-Mi Go,Dean P. Jones +1 more
TL;DR: The critical nature of the proinflammatory redox signaling and cell biology associated with E(h)CySS supports the use of plasma levels of Cys, CySS, and E( h)Cy SS as key indicators of vascular health.
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Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis.
TL;DR: Assessment of the effect of random assignment to fluid resuscitation with albumin or saline on organ function and mortality in patients with severe sepsis and pre-defined subgroup analysis of a randomized controlled trial conducted in the intensive care units of 16 hospitals in Australia and New Zealand found that administration of albumin compared to saline did not impair renal or other organ function or decrease the risk of death.
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Status of glutathione and other thiols and disulfides in human plasma
Wayne Kleinman,John P. Richie +1 more
TL;DR: Low levels, stability, and distribution of biologically relevant thiols and disulfides in human plasma were assessed and a method for their comprehensive and accurate determination was provided.
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Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite.
TL;DR: Human serum albumin (HSA), the most abundant protein in plasma, has been proposed to have an antioxidant role and HSA-SOH is proposed to serve as an intermediate in the formation ofLow molecular weight disulfides, which are the predominant plasma form of low molecular weight thiols, and in theformation of mixed HSA disulfide, which is present in approximately 25% of circulating HSA.
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Location of High and Low Affinity Fatty Acid Binding Sites on Human Serum Albumin Revealed by NMR Drug-competition Analysis
TL;DR: It is shown that FA sites 2, 4 and 5 bind FA with high affinity, while sites 1, 3, 6 and 7 exhibit low affinity for FA, thus providing the first complete determination of relative affinities of all seven long-chain FA sites on HSA.