The thiol pool in human plasma: the central contribution of albumin to redox processes.
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TLDR
A critical review of the plasma thiol pool is provided with a focus on human serum albumin, an important target for oxidants and electrophiles due to its reactivity with a wide variety of species and its relatively high concentration.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01 and is currently open access. It has received 519 citations till now. The article focuses on the topics: Human serum albumin & Thiol.read more
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An overview of albumin and alpha-1-acid glycoprotein main characteristics: highlighting the roles of amino acids in binding kinetics and molecular interactions
TL;DR: This review summarizes the common knowledge about the structural and molecular characteristics of both ALB and AGP in humans, and about the most involved amino acids in their high-affinity binding pockets, and is useful for the design of new drug entities with high-binding characteristics.
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Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors.
TL;DR: Data regarding sulfur drugs commonly used in clinical practice that can support the hypothesis about H2S-dependent pharmacotherapeutic effects of these drugs are reviewed.
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Binding of Janus kinase inhibitor tofacitinib with human serum albumin: multi-technique approach
TL;DR: Investigation of the binding affinity of tofacitinib with human serum albumin under simulated physiological conditions by using UV–visible spectroscopy, fluorescence quenching measurements, dynamic light scattering, differential scanning calorimetry (DSC) and molecular docking methods demonstrates that fluorescence intensity of HSA gets quenched by tofac itinib and quench occurs in static manner.
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Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research.
Waseem Jerjes,Theodossis A. Theodossiou,Henry Hirschberg,Anders Høgset,Anette Weyergang,Pål Kristian Selbo,Zaid Hamdoon,Colin Hopper,Kristian Berg,Kristian Berg +9 more
TL;DR: PCI has been shown to improve the biological activity of a number of macromolecules that do not readily penetrate the plasma membrane, including type I ribosome-inactivating proteins (RIPs), gene-encoding plasmids, adenovirus and oligonucleotides and certain chemotherapeutics, such as bleomycin.
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How does thiol/disulfide homeostasis change in prediabetic patients?
TL;DR: It is shown for the first time that thiol oxidation increases in prediabetic patients and that there is a positive correlation between the disulfide and blood glucose and HbA1c levels.
References
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Bilirubin is an antioxidant of possible physiological importance
TL;DR: The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
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Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
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Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.