Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
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Ang II and EGF synergistically induce COX-2 expression via CREB in intestinal epithelial cells.
TL;DR: Results indicate that co‐stimulation with Ang II and EGF synergistically induced COX‐2 expression in these intestinal epithelial cells through p38MAPK mediated signaling cascades that converge onto CREB.
Journal ArticleDOI
Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in isolated hippocampus of rats: Molecular, biochemical and histological evidences.
Majid Motaghinejad,Manijeh Motevalian,Fatemeh Babalouei,Mohammad Abdollahi,Mansour Heidari,Zahra Madjd +5 more
TL;DR: TPM can probably act as a neuroprotective agent against MPH induced neurotoxicity and this might have been mediated by CREB/BDNF signaling pathway.
Journal ArticleDOI
Modulation of Aanat gene transcription in the rat pineal gland.
Anthony K. Ho,Constance L. Chik +1 more
TL;DR: The pineal gland is highlighted as an excellent model system for studying neurotransmitter‐regulated rhythmic gene expression and signaling mechanisms involving modification of constitutively expressed proteins and those requiring synthesis of new proteins are reviewed.
Journal ArticleDOI
Role of AP-1 in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene up-regulation in mouse cortical neurons.
Mei Qiang,Maharaj K. Ticku +1 more
TL;DR: The results suggest that AP‐1 is an active regulator of the NR2B transcription and ethanol‐induced changes may result at multiple levels in the regulation includingAP‐1 proteins expression, CREB phosphorylation and perhaps reorganization of dimmers.
Journal ArticleDOI
Assembly of the N-cadherin complex during synapse formation involves uncoupling of p120-catenin and association with presenilin 1
TL;DR: Changes in the molecular composition of the N-cadherin complex (represented by the uncoupling of p120-catenin and association with PS1) may correspond to distinct functional states of the complex involved in synaptic maturation.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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