Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
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Journal ArticleDOI
Single-Molecule Imaging Reveals Dynamics of CREB Transcription Factor Bound to Its Target Sequence
Noriyuki Sugo,Masatoshi Morimatsu,Yoshiyuki Arai,Yoshinori Kousoku,Aya Ohkuni,Taishin Nomura,Toshio Yanagida,Nobuhiko Yamamoto +7 more
TL;DR: It is suggested that CREB stimulates transcription by binding transiently to CRE in the time range of several seconds, which would suggest that the transcription factor contributes to gene regulation by recruiting the basal transcriptional machinery.
Journal ArticleDOI
Minocycline provides protection against ß-amyloid(25-35)-induced alterations of the somatostatin signaling pathway in the rat temporal cortex
TL;DR: The present data demonstrate that minocycline in vivo provides protection against Abeta-induced impairment of the SRIF signal transduction pathway in the rat temporal cortex and suggest that it may have a potential as a therapeutic agent in human Alzheimer's disease, although further studies are warranted.
Journal ArticleDOI
The immunosuppressive drugs cyclosporin A and tacrolimus inhibit membrane depolarization-induced CREB transcriptional activity at the coactivator level.
Elke Oetjen,Kai-Martin Thoms,Yvonne Laufer,Daniela Pape,R. Blume,Pingfeng Li,Willhart Knepel +6 more
TL;DR: The data suggest that, in contrast to NFAT, cyclosporin A and tacrolimus inhibit CREB transcriptional activity at the coactivator level.
Journal ArticleDOI
Comparison of different protocols for neural differentiation of human induced pluripotent stem cells.
TL;DR: Neural differentiation potential of three induction media for conversion of hiPSCs into neural lineages is compared and results indicated a successful establishment protocol with high efficiency for differentiation of hi PSCs into Neural lineages.
The effects of Ankaferd ® Blood Stopper on transcription factors in HUVEC and the erythrocyte protein profile Ankaferd ® Kanama Durdurucunun HUVEC'lerde transkripsiyon faktörleri ve eritrosit protein profili üzerine etkisi
TL;DR: The present study investigated the effects of ABS on endothelium, and possible transcription factor changes in HUVEC (human umbilical vein endothelial cells) and the erythrocyte membrane profile to establish a very fast and solid protein web, and increased the level of transcription factor activation.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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