Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
Reads0
Chats0
TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
More filters
Journal ArticleDOI
Function and Regulation of CREB Family Transcription Factors in the Nervous System
Bonnie E. Lonze,David D. Ginty +1 more
TL;DR: This review focuses on the current level of understanding of where, when, and how CREB family members function in the nervous system.
Journal ArticleDOI
Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function
TL;DR: These transcriptional paradigms provide a basic framework for understanding the integration of mitochondrial biogenesis and function with signaling events that dictate cell- and tissue-specific energetic properties.
Journal ArticleDOI
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
TL;DR: Perturbations in the balance between synaptic and extrasynaptic NMDAR activity contribute to neuronal dysfunction in acute ischaemia and Huntington's disease, and could be a common theme in the aetiology of neurodegenerative diseases.
Journal ArticleDOI
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Akinobu Suzuki,Sarah A. Stern,Ozlem Bozdagi,George W. Huntley,Ruth H. Walker,Pierre J. Magistretti,Cristina M. Alberini +6 more
TL;DR: It is concluded that astrocyte-neuron lactate transport is required for long-term memory formation, suggesting that lactate import into neurons is necessary for long -term memory.
Journal ArticleDOI
The many faces of CREB
TL;DR: Emerging evidence suggests that strategies that exploit regional differences in upstream factors or that target specific CREB-regulated genes, rather than CREB itself, could make a promising contribution to the treatment of neuropsychiatric conditions.
References
More filters
Journal ArticleDOI
PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling.
Andreia M. Ionescu,Edward M. Schwarz,Charles Vinson,J. Edward Puzas,Randy N. Rosier,Paul R. Reynolds,Regis J. O'Keefe +6 more
TL;DR: It is shown that both cAMP response element-binding protein (CREB) and AP-1 activation are critical to PTHrP signaling in chondrocytes, and in combination, the effects of dominant negative c-Fos and CREB are synergistic, suggesting interaction between these signaling pathways during chONDrocyte differentiation.
Journal ArticleDOI
DNA specificity enhanced by sequential binding of protein monomers.
TL;DR: This work shows that members of the basic region leucine zipper and basic region helix-loop-helix zipper transcription factor families follow an assembly pathway in which two protein monomers bind DNA sequentially and form their dimerization interface while bound to DNA.
Journal ArticleDOI
Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I tax and CREB.
TL;DR: The mechanism by which Tax activates gene expression in conjunction with members of the ATF/CREB family is investigated and the domains required for interaction between Tax and CREB are likely critical for the activation of HTLV-I gene expression.
Journal ArticleDOI
Characterization of a CREB Gain-of-Function Mutant with Constitutive Transcriptional Activity In Vivo
TL;DR: Results demonstrate that Ser133 phosphorylation is sufficient for cellular gene activation and that additional signal-dependent modifications of CBP or p300 are not required for recruitment of the transcriptional apparatus to the promoter.
Journal ArticleDOI
Differential regulation of respiratory chain subunits by a CREB-dependent signal transduction pathway. Role of cyclic AMP in cytochrome c and COXIV gene expression.
TL;DR: It is demonstrated that cytochrome c but not COXIV mRNA is induced by cAMP through a mechanism involving transcriptional activation, establishing that respiratory chain gene expression can be regulated directly by camp through a CREB-dependent signal transduction pathway.
Related Papers (5)
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals.
Function and Regulation of CREB Family Transcription Factors in the Nervous System
Bonnie E. Lonze,David D. Ginty +1 more