Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
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Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat
TL;DR: An increase in the transcription of genes coding for proteins involved in synaptic plasticity and synaptic activity in the FC is found, and it is found that the gene expression profile of APDs is different between FC and striatum.
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The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells.
Thomas C. Chen,Pia Wadsten,Susan Su,Neal Rawlinson,Florence M. Hofman,Colin K Hill,Axel H. Schönthal +6 more
TL;DR: The results suggest that rolipram could prove useful as a novel differentiating agent with both cytostatic and cytotoxic potential in the treatment of malignant gliomas.
Journal ArticleDOI
Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation.
Tae-Don Kim,Jong-So Kim,Jong Heon Kim,Jihwan Myung,Hee-Don Chae,Kyung-Chul Woo,Sung Key Jang,Duk Su Koh,Kyong-Tai Kim +8 more
TL;DR: A mathematical model for the AANAT mRNA profile and its experimental evidence with rat pinealocytes indicates that rhythmic AANat mRNA degradation mediated by hnRNP R, hNRNP Q, and hn RNP L is a key process in the regulation of its circadian oscillation.
Journal ArticleDOI
MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1
Jie Tian,Ke Rui,Xinyi Tang,Jie Ma,Yungang Wang,Xinyu Tian,Yue Zhang,Huaxi Xu,Liwei Lu,Shengjun Wang +9 more
TL;DR: In this study, inhibition of microRNA (miR)-9 promoted the differentiation of MDSCs with significantly reduced immunosuppressive function whereas overexpression of miR-9 markedly enhanced the function of M DSCs.
Journal ArticleDOI
Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory.
Mio Nonaka,Ryang Kim,Hotaka Fukushima,Kazuki Sasaki,Kanzo Suzuki,Michiko Okamura,Yuichiro Ishii,Takashi Kawashima,Satoshi Kamijo,Sayaka Takemoto-Kimura,Hiroyuki Okuno,Satoshi Kida,Haruhiko Bito +12 more
TL;DR: It is shown that several constitutive kinase pathways and an activity-regulated phosphatase, calcineurin, converge to determine the nucleocytoplasmic shuttling of CRTC1, which has a wide impact on CREB-dependent memory processes, but fine-tunes CREB output in a region-specific manner.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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