Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
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Cholesterol depletion reduces serotonin binding and signaling via human 5-HT7(a) receptors
TL;DR: It is demonstrated that cholesterol depletion decreases binding of both agonist and antagonist radioligands to 5-HT(7) receptor-mediated intracellular signaling and counteracted by pre-treatment with cholesterol synthesis inhibitors.
Journal ArticleDOI
Akt- and CREB-Mediated Prostate Cancer Cell Proliferation Inhibition by Nexrutine, a Phellodendron amurense Extract
Gretchen E. Garcia,Arevalo Nicole,Shylesh Bhaskaran,Ashima Gupta,Natasha Kyprianou,Addanki P. Kumar +5 more
TL;DR: The results suggest that Nexrutine inhibits tumor cell proliferation through apoptosis induction and inhibition of cell survival signaling, and induces apoptosis in prostate cancer cells stably overexpressing Bcl-2.
Journal ArticleDOI
Pentoxifylline Attenuates Lung Injury and Modulates Transcription Factor Activity in Hemorrhagic Shock
Jessica Deree,Joilson O. Martins,Tercio De Campos,James G. Putnam,William H. Loomis,Paul L. Wolf,Raul Coimbra +6 more
TL;DR: The addition of PTX to conventional RL infusion after shock significantly reduced histological lung injury and pulmonary neutrophil activity when compared to treatment with RL alone and may serve as a novel therapeutic adjunct after hemorrhagic shock.
Journal ArticleDOI
Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.
Uma K. Misra,Salvatore V. Pizzo +1 more
TL;DR: It is concluded that B‐Raf/ERK and mTOR signaling play an essential role in cAMP‐dependent, but PKA‐independent, proliferation of cancer cells.
Journal ArticleDOI
Mechanism of TiO2 nanoparticle-induced neurotoxicity in zebrafish (Danio rerio).
Lei Sheng,Ling Wang,Mingyu Su,Xiaoyang Zhao,Renping Hu,Xiaohong Yu,Jie Hong,Dong Liu,Bingqing Xu,Yunting Zhu,Han Wang,Fashui Hong +11 more
TL;DR: The findings imply that low dose exposures of TiO2 NPs may result in the brain damages in zebrafish, provide a developmental basis for evaluating the neurotoxicity of subchronic exposure, and raise the caution of aquatic application of TiNPs.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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