Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
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Valproic acid regulates catecholaminergic pathways by concentration-dependent threshold effects on TH mRNA synthesis and degradation
Antoni D'Souza,Eylem Onem,Eylem Onem,Pranav Patel,Pranav Patel,Edmund F. La Gamma,Edmund F. La Gamma,Bistra B. Nankova,Bistra B. Nankova +8 more
TL;DR: Increasing concentrations of VPA demonstrated opposing effects on TH mRNA and protein abundance: elevation of both at low concentrations but attenuation at concentrations higher than 0.5 mM, consistent with a novel and previously unrecognized cellular/molecular drug regulatory step at the level of TH mRNA stability.
Journal ArticleDOI
Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease
Vassilios Beglopoulos,Jie Shen +1 more
TL;DR: Modulation of CRE-dependent transcription might be beneficial for the treatment of dementia in AD through modulation of phosphodiesterase 4 and histone deacetylase inhibitors.
Journal ArticleDOI
PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings
Byung Jun Ryu,Hyuk Lee,Seong Ho Kim,Jung-Nyoung Heo,Sik-Won Choi,Jeong-Tae Yeon,Jeongmin Lee,Jongsung Lee,Jae Youl Cho,Seong Hwan Kim,Sang Yeol Lee +10 more
TL;DR: It is reported that recently developed p21-activated kinase 4 inhibitor PF-3758309 shows anti-metastatic effect in A549 human lung cancer cell and suppresses CREB, NF-κB, and β-catenin pathways, which are well known to be closely related with cell migration.
Journal ArticleDOI
Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells
TL;DR: Novel roles for CREB and AhR are identified as major, specific regulators of FSCN-1 transcription in human carcinoma cells but do not support the hypothesis that β-catenin signaling has a central role.
Journal ArticleDOI
The soy isoflavone genistein induces estrogen synthesis in an extragonadal pathway.
Lan Ye,Ming Y. Chan,Lai K. Leung +2 more
TL;DR: An extragonadal pathway by which genistein might increase estrogen synthesis is illustrated by demonstrating the involvement of protein kinases in the gene regulation of CYP19.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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