Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
Reads0
Chats0
TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
More filters
Journal ArticleDOI
Preconditioning Doses of NMDA Promote Neuroprotection by Enhancing Neuronal Excitability
Francesc X. Soriano,Sofia Papadia,Frank Hofmann,Neil Robert Hardingham,Hilmar Bading,Giles E. Hardingham +5 more
TL;DR: Exposure to low preconditioning doses of NMDA results in preferential activation of synaptic NMDA receptors because of a dramatic increase in action potential firing, in apparent contradiction with recent findings that extrasynaptic NMDA receptor signaling exerts a dominant inhibitory effect on prosurvival signaling from synapticNMDA receptors.
Journal ArticleDOI
Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory?
Detlef Balschun,David P. Wolfer,Peter Gass,Theo Mantamadiotis,Hans Welzl,Günther Schütz,Julietta U. Frey,Hans-Peter Lipp +7 more
TL;DR: It is indicated that in the adult mouse brain, loss of CREB neither prevents learning nor substantially affects performance in some hippocampus-dependent tasks, and it spares LTP and LTD in paradigms that are sensitive enough to detect deficits in other mutants.
Journal ArticleDOI
The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia
Deepa B. Shankar,Jerry C. Cheng,Kentaro Kinjo,Noah Federman,Theodore B. Moore,Amandip Gill,Nagesh Rao,Elliot M. Landaw,Kathleen M. Sakamoto +8 more
TL;DR: It is reported that CREB is implicated in myeloid cell transformation, a transcription factor that functions in glucose homeostasis, growth factor-dependent cell survival, and memory that is associated with increased risk of relapse and decreased event-free survival.
Journal ArticleDOI
Regulation and function of immediate-early genes in the brain: beyond neuronal activity markers.
TL;DR: An overview of the history and recent work on regulation and function of neuronal immediate-early genes, including Arc/arg3.1, is presented, in which various immediate- early genes underlie several distinct processes required for long-term synaptic changes and memory formation.
Journal ArticleDOI
Coupling of the NMDA receptor to neuroprotective and neurodestructive events.
TL;DR: Increased understanding in this field is leading to the discovery of new therapeutic targets and strategies for excitotoxic disorders, as well as a growing appreciation of the harmful consequences of NMDA receptor blockade.
References
More filters
Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
Related Papers (5)
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals.
Function and Regulation of CREB Family Transcription Factors in the Nervous System
Bonnie E. Lonze,David D. Ginty +1 more