Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
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Function and regulation of the glutathione peroxidase homologous gene GPXH/GPX5 in Chlamydomonas reinhardtii
Beat B. Fischer,Régine Dayer,Yvonne Schwarzenbach,Stéphane D. Lemaire,Renata Behra,Anja Liedtke,Rik I.L. Eggen +6 more
TL;DR: It is shown that the GPXH protein is a thioredoxin-dependent peroxidase catalyzing the reduction of hydrogen peroxide and organic hydroperoxides and seems to encode a dual-targeted protein, predicted to be localized both in the chloroplast and the cytoplasm, which is active with either plastidic TRXy or cytosolic TRXh1.
Journal ArticleDOI
Attention deficit induced by blockade of N-methyl d-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: Role of metabotropic glutamate receptors 2/3
Laura Pozzi,Marta Baviera,Giuseppina Sacchetti,Eleonora Calcagno,Claudia Balducci,Roberto W. Invernizzi,Mirjana Carli +6 more
TL;DR: The data provide evidence that enhanced glutamate release and phosphorylation of cAMP response element binding protein (CREB) on serine 133 may be associated to attention deficit and loss of impulse control and suggest that mGluR2/3 agonists have a therapeutic potential for cognitive deficits.
Journal ArticleDOI
Neonatal separation stress reduces glial fibrillary acidic protein- and S100β-immunoreactive astrocytes in the rat medial precentral cortex
Kristina Musholt,Giovanni Cirillo,Carlo Cavaliere,Maria Rosaria Bianco,Joerg Bock,Carina Helmeke,Katharina Braun,Michele Papa +7 more
TL;DR: The observed downregulation of glia‐specific marker proteins is in line with the hypothesis that emotional experience can alter glia cell activation in the juvenile limbic system.
Journal ArticleDOI
Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis
Yuxin Wu,Quan Pan,Hui Yan,Kebin Zhang,Xiaoqin Guo,Zihui Xu,Wanbao Yang,Yajuan Qi,Cathy A. Guo,Caitlyn Hornsby,Lin Zhang,Aimin Zhou,Ling Li,Yunmei Chen,Weiping Zhang,Yuxiang Sun,Hongting Zheng,Fred Wondisford,Ling He,Shaodong Guo +19 more
TL;DR: A novel Foxo1 regulatory mechanism by glucagon is found, which promotesFoxo1 nuclear translocation and stability via cAMP- and protein kinase A–dependent phosphorylation of Foxo 1 at Ser276, which is a new target site identified in the control of Foxe1 bioactivity and associated metabolic diseases.
Journal ArticleDOI
GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala.
Lida Zhang,Jianwei Wang,Yong Liu,X.-B. Lu,Y. Kuang,Y.-H. Wan,Yuhong Chen,H.-M. Yan,Jian Fei,Zhugang Wang +9 more
TL;DR: The data indicate that Gpr26 is important for emotion regulation in mice, a function probably mediated by the phosphorylation of CREB in the central amygdala.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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