Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
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Altered expression of CYP in TSOD mice: a model of type 2 diabetes and obesity.
Toshiyuki Kudo,Tsutomu Shimada,Takahiro Toda,S. Igeta,Wataru Suzuki,Nobutomo Ikarashi,Wataru Ochiai,Kiyomi Ito,Masaki Aburada,Kiyoshi Sugiyama +9 more
TL;DR: Altered CYP expression in TSOD mice suggests that the biotransformation of drugs metabolized by these CYP enzymes differs from that in normal animals, and may be useful in elucidating changes in pharmacokinetics in obese/diabetic patients.
Journal ArticleDOI
Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain.
TL;DR: It is demonstrated that co-administration of forskolin and phorbol ester TPA to NIH3T3 cells provoked a dose-dependent increase in phosphoserine-133, which may contribute to synergistic activation of CREB-mediated transcription.
Journal ArticleDOI
Expression profile of CREB knockdown in myeloid leukemia cells
Matteo Pellegrini,Jerry C. Cheng,Jon Voutila,Dejah R. Judelson,Julie Taylor,Stanley F. Nelson,Kathleen M. Sakamoto,Kathleen M. Sakamoto +7 more
TL;DR: A high confidence list of CREB targets in K562 cells allow us to begin to understand the mechanisms by which CREB contributes to acute leukemia and speculate that regulation of histone genes may play an important role by possibly altering the regulation of DNA replication during the cell cycle.
Journal ArticleDOI
Activation of TORC1 Transcriptional Coactivator through MEKK1-induced Phosphorylation
TL;DR: The findings suggest a new mechanism for regulated activation of TORC1 transcriptional coactivator and CREB signaling through MEKK1-mediated phosphorylation, which is independent of downstream effectors MEK1/MEK2, ERK2
Journal ArticleDOI
Molecular determinants of cardiac memory and their regulation.
TL;DR: The signal transduction mechanisms and ion channel changes that are initiated by altered activation and that contribute to the expression of cardiac memory are the major focus of this review.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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