Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
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A GNAS Mutation Found in Pancreatic Intraductal Papillary Mucinous Neoplasms Induces Drastic Alterations of Gene Expression Profiles with Upregulation of Mucin Genes
Hirotake Komatsu,Etsuko Tanji,Naoaki Sakata,Takeshi Aoki,Fuyuhiko Motoi,Takeshi Naitoh,Yu Katayose,Shinichi Egawa,Michiaki Unno,Toru Furukawa +9 more
TL;DR: In this article, the authors examined in vitro phenotypes of cells of pancreatic ductal lineage, HPDE, PK-8, PCI-35 and MIA PaCa-2, with exogenous expression of either wild-type or mutated (R201H) GNAS.
Journal ArticleDOI
Store-Operated Ca2+ Entry Activates the CREB Transcription Factor in Vascular Smooth Muscle
TL;DR: It is reported that SOCE activates CREB in both cultured smooth muscle cells and intact arteries, and indicates that Ca2+ entry through store-operated Ca2-operated channels leads to CREB activation, suggesting that SOCe contributes to the regulation of gene expression in vascular smooth muscle.
Journal ArticleDOI
Role of basic region leucine zipper transcription factors cyclic AMP response element binding protein (CREB), CREB2, activating transcription factor 2 and CAAT/enhancer binding protein alpha in cyclic AMP response element-mediated transcription.
TL;DR: Experiments involving dominant‐negative bZIP mutants revealed that CREB does not heterodimerize with CREB2, ATF2, c‐Jun or C/EBP; rather, CREB and ATF2 compete for binding to the CRE, and are independently able to up‐regulate transcription of genes containing CRE motifs in their regulatory regions.
Journal ArticleDOI
Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management.
Fanny Chui Fun Ip,Yu Pong Ng,Hui Jin An,Ying Dai,Hai Hong Pang,Yue Qing Hu,Allison C. Chin,Calvin B. Harley,Yung Hou Wong,Nancy Y. Ip +9 more
TL;DR: It is demonstrated that CAG stimulates telomerase activity and cell proliferation in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression, and may have a novel therapeutic role in depression.
Journal ArticleDOI
Active CREB1 Promotes a Malignant TGFβ2 Autocrine Loop in Glioblastoma
Laura Rodon,Alba Gonzalez-Junca,María del Mar Inda,Ada Sala-Hojman,Elena Martínez-Sáez,Joan Seoane,Joan Seoane +6 more
TL;DR: The molecular mechanisms responsible for the aberrantly high levels of TGFβ2 found in certain tumors are discerned, and biomarkers to predict the clinical response to anti-TGFβ therapies are proposed.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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