Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
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Respiratory chain complex I, a main regulatory target of the cAMP/PKA pathway is defective in different human diseases
Sergio Papa,Domenico De Rasmo,Zuzana Technikova-Dobrova,Damiano Panelli,Anna Signorile,Salvatore Scacco,Vittoria Petruzzella,Francesco Papa,Giuseppe Palmisano,Antonio Gnoni,Loris Micelli,Anna Maria Sardanelli +11 more
TL;DR: The work reviewed here shows that the cAMP/PKA pathway regulates the biogenesis, assembly and catalytic activity of complex I and mitochondrial oxygen superoxide production.
Journal ArticleDOI
Injury-induced activation of the MAPK/CREB pathway triggers apoptosis-induced compensatory proliferation in hydra head regeneration.
TL;DR: In this article, pharmacological inhibition of the MAPK/ERK pathway or RNAi knockdown of the RSK, CREB, and CREB binding protein (CBP) genes prevents apoptosis, compensatory proliferation and blocks head regeneration.
Journal ArticleDOI
Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury?
TL;DR: This work will review recent advances in understanding of unique transcriptional responses to moderate levels of alveolar hypoxia in the lung that apparently allow it to express an inflammatory phenotype at levels of Hypoxia that would not produce such a response in other organs.
Journal ArticleDOI
Prostaglandin E2 suppresses the differentiation of retinoic acid–producing dendritic cells in mice and humans
TL;DR: Prostaglandin E2 inhibits the expression of retinal dehydrogenase, thus inhibiting retinoic acid production and the priming of gut-tropic T cells by dendritic cells.
Journal ArticleDOI
Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration.
TL;DR: In this paper, the authors measured cocaine-induced phosphorylation of multiple cAMP-dependent and independent protein substrates in mesolimbic dopamine terminal regions following chronic self-administration.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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