Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
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Journal ArticleDOI
Activation of the Mitogen-Activated Protein Kinase (ERK1/2) Signaling Pathway by Cyclic AMP Potentiates the Neuroprotective Effect of the Neurotransmitter Noradrenaline on Dopaminergic Neurons
Jean-Denis Troadec,Marc Marien,Sophie Mourlevat,Thomas Debeir,Merle Ruberg,Francis Colpaert,Patrick P. Michel +6 more
TL;DR: The data suggest that the MAPK signaling pathway plays a key role in the trophic effects that cAMP elevating agents and NA cooperatively exert on TH(+) neurons.
Journal ArticleDOI
Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers.
Suzanne E. Elcombe,Shaista Naqvi,Mirjam W. M. Van Den Bosch,Kirsty F. MacKenzie,Francesca R. Cianfanelli,Gordon D. Brown,J. Simon C. Arthur +6 more
TL;DR: It is found that zymosan, via dectin-1 activation, also leads to the expression of SphK1 and LIGHT, markers of a regulatory like phenotype in mouse macrophages, and this regulation is dependent on the ability of MSKs to phosphorylate the transcription factor CREB.
Journal ArticleDOI
Dioxin Increases C/EBPβ Transcription by Activating cAMP/Protein Kinase A
Christoph F.A. Vogel,Eric Sciullo,Sujin Park,Christian Liedtke,Christian Trautwein,Fumio Matsumura +5 more
TL;DR: The regulatory mechanism of TCDD-mediated transcriptional activation of C/EBPβ is mediated via PKA-dependent CREB activation, and Gel shift analyses demonstrated that CREB itself binds to the putative CREB motif that mediates the TCDd-dependent effect on C/ EBPβ gene transcription.
Journal ArticleDOI
Exercise therapy normalizes BDNF upregulation and glial hyperactivity in a mouse model of neuropathic pain.
Cayo Almeida,Aline dos Santos deMaman,Ricardo Kusuda,F. Cadetti,Maria Ida Bonini Ravanelli,André L. Queiroz,Thais Amaral e Sousa,Sonia Zanon,Leonardo R. Silveira,Guilherme de Araújo Lucas +9 more
TL;DR: Exercise therapy induces long-lasting analgesia through various mechanisms associated with the onset and advanced stages of neuropathy, and the data support further studies to clarify whether appropriate exercise intensity, volume, and duration can also cause long- lasting pain relief in patients with neuropathic pain.
Journal ArticleDOI
Silencing cAMP-response Element-binding Protein (CREB) Identifies CYR61 as a Tumor Suppressor Gene in Melanoma
Andrey S. Dobroff,Hua Wang,Vladislava O. Melnikova,Gabriel J. Villares,Maya Zigler,Li Huang,Menashe Bar-Eli +6 more
TL;DR: Stably silencing CREB expression in two human metastatic melanoma cell lines, A375SM and C8161-c9, suppresses tumor growth and experimental metastasis and Promoter analysis and chromatin immunoprecipitation assays demonstrated that CREB acts as a negative regulator of CCN1/CYR61 transcription by directly binding to its promoter.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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