Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
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Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIP(L) and MKP-1, thereby antagonizing UV-induced apoptosis.
TL;DR: CAMP antagonized UV-induced apoptosis in Rat-1 and NIH 3T3 cells and provided a molecular mechanism by which cAMP suppresses JNK activation and antagonizes apoptosis.
Journal ArticleDOI
Epigallocatechin Gallate Inhibits Phorbol Ester-Induced Activation of NF-B and CREB in Mouse Skin: Role of p38 MAPK
TL;DR: EGCG inhibited TPA‐induced DNA binding of NF‐κB and CREB by blocking activation of p38 MAPK, which may provide a molecular basis of COX‐2 inhibition by EGCG in mouse skin in vivo.
Journal ArticleDOI
ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons.
Michal Toborek,Kwang Won Son,Anna Pudełko,Kelley King-Pospisil,Edward Wylegala,Andrzej Małecki +5 more
TL;DR: Results of the present study indicate that the ERK1/2 pathway is involved in anti‐apoptotic effects of Nicotine in spinal cord neurons and may be involved in therapeutic effects of nicotine in spinal Cord trauma.
Journal ArticleDOI
Resistin increases monolayer permeability of human coronary artery endothelial cells.
TL;DR: Results provide new evidence that resistin may contribute to the vascular lesion formation via increasing endothelial permeability through the mechanism of oxidative stress and the activation of p38 MAPK.
Journal ArticleDOI
The role of CREB as a proto-oncogene in hematopoiesis.
TL;DR: CREB acts as a proto-oncogene to regulate hematopoiesis and contributes to the leukemia phenotype, and its results suggest that CREB-dependent pathways may serve as targets for directed therapies in leukemia in the future.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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