Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
Reads0
Chats0
TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
More filters
Journal ArticleDOI
Epigenetic treatments of adult rats promote recovery from visual acuity deficits induced by long-term monocular deprivation.
TL;DR: It is found that chronic intraperitoneal administration of valproic acid or sodium butyrate to long‐term monocularly deprived adult rats coupled with reverse lid‐suturing caused a complete recovery of visual acuity.
Journal ArticleDOI
CREB is a critical regulator of normal hematopoiesis and leukemogenesis.
Jerry C. Cheng,Kentaro Kinjo,Dejah R. Judelson,Jenny Chang,Winston S. Wu,Ingrid Schmid,Deepa B. Shankar,Noriyuki Kasahara,Renata Stripecke,Ravi Bhatia,Elliot M. Landaw,Kathleen M. Sakamoto +11 more
TL;DR: It is shown that cAMP-responsive element binding protein (CREB) is most highly expressed in lineage negative hematopoietic stem cells (HSCs), suggesting that CREB is critical for normal myelopoiesis and leukemia cell proliferation.
Journal ArticleDOI
Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation.
TL;DR: It is proposed that SirT1-dependent Creb deacetylation regulates the balance between glucose and lipid metabolism, integrating fasting signals.
Journal ArticleDOI
Long non-coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling.
Jin Yao,Xiao‐Qun-Q. Wang,Yu‐Jie-J. Li,Kun Shan,Hong Yang,Yang‐Ning‐Zhi-N.-Z. Wang,Mu‐Di-D. Yao,Chang Liu,Xiu‐Miao-M. Li,Yi Shen,Jing‐Yu-Y. Liu,Hong Cheng,Jun Yuan,Yang‐Yang-Y. Zhang,Qin Jiang,Biao Yan +15 more
TL;DR: This study reveals that MALAT1 might regulate the development of retinal neurodegeneration through CREB signaling.
Journal ArticleDOI
Neurological Enhancement Effects of Melatonin against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via AMPK/CREB Signaling
Shafiq Ur Rehman,Muhammad Ikram,Najeeb Ullah,Najeeb Ullah,Sayed Ibrar Alam,Hyun Young Park,Haroon Badshah,Kyonghwan Choe,Myeong Ok Kim +8 more
TL;DR: It is demonstrated that traumatic brain injury (TBI) evokes oxidative stress, disrupts brain energy homeostasis, and boosts neuroinflammation, which further contributes to neuronal degeneration and cognitive dysfunction in the mouse brain, and that melatonin treatment overcomes energy depletion and protects against brain damage via the regulation of p-AMPK/p-CREB signaling pathways.
References
More filters
Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
Related Papers (5)
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals.
Function and Regulation of CREB Family Transcription Factors in the Nervous System
Bonnie E. Lonze,David D. Ginty +1 more