Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
Reads0
Chats0
TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
More filters
Journal ArticleDOI
Mitochondrial Cyclic AMP Response Element-binding Protein (CREB) Mediates Mitochondrial Gene Expression and Neuronal Survival
Junghee Lee,Junghee Lee,Chun-Hyung Kim,David Simon,Leila R. Aminova,Alexander Y. Andreyev,Yulia Kushnareva,Anne N. Murphy,Bonnie E. Lonze,Kwang-Soo Kim,David D. Ginty,Robert J. Ferrante,Robert J. Ferrante,Hoon Ryu,Hoon Ryu,Rajiv R. Ratan +15 more
TL;DR: It is reported that CREB is present in the mitochondrial matrix of neurons and that it binds directly to cyclic AMP response elements (CREs) found within the mitochondrial genome, demonstrating that regulation of mitochondrial gene expression by mitochondrial CREB, in part, underlies the protective effects of CREB.
Journal ArticleDOI
Differential miRNA Expression in Omental Adipose Tissue and in the Circulation of Obese Patients Identifies Novel Metabolic Biomarkers
TL;DR: Omental fat tissue and systemic miRNA levels reflect components of the metabolic syndrome, highlighting their potential as novel biomarkers for this complex syndrome.
Journal ArticleDOI
The Hepatitis B Virus X Protein Functionally Interacts with CREB-binding Protein/p300 in the Regulation of CREB-mediated Transcription
Delphine Cougot,Yuanfei Wu,Stefano Cairo,Julie Caramel,Claire-Angélique Renard,Laurence Lévy,Marie Annick Buendia,Christine Neuveut +7 more
TL;DR: It is shown that HBx and CBP/p300 synergistically enhanced CREB activity and that CREB phosphorylation by protein kinase A was a prerequisite for the cooperative action of HBxand CBP-binding protein (CBP)/p300 in regulating CREB transcriptional activity.
Journal ArticleDOI
Signalling in viral entry.
TL;DR: It is illustrated that multiple activation of host cells during viral entry profoundly impacts the elaborate relationship between hosts and viral pathogens.
Journal ArticleDOI
Adipocyte CREB promotes insulin resistance in obesity.
Ling Qi,Maziyar Saberi,Erik Zmuda,Yiguo Wang,Judith Y. Altarejos,Xinmin Zhang,Renaud Dentin,Susie Hedrick,Gautam Bandyopadhyay,Tsonwin Hai,Jerry Olefsky,Marc Montminy +11 more
TL;DR: Results indicate that adipocyte CREB provides an early signal in the progression to type 2 diabetes.
References
More filters
Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
Related Papers (5)
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals.
Function and Regulation of CREB Family Transcription Factors in the Nervous System
Bonnie E. Lonze,David D. Ginty +1 more