Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
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Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice
Paulus Kirchhof,Eloi Marijon,Larissa Fabritz,Na Li,Wei Wang,Tiannan Wang,Kirsten Schulte,Juliane Hanstein,Jan S. Schulte,Mathis Vogel,Nathalie Mougenot,Sandra Laakmann,Lisa Fortmueller,Jens Eckstein,Sander Verheule,Sven Kaese,Ariane Staab,Stephanie Grote-Wessels,Ulrich Schotten,Ghassan Moubarak,Xander H.T. Wehrens,Wilhelm Schmitz,Stéphane N. Hatem,Frank U. Müller +23 more
TL;DR: It is concluded that transcription factor CREM is an important regulator of atrial growth implicated in the development of an arrhythmogenic substrate in TG mice.
Journal ArticleDOI
The role of cyclic-AMP binding protein (CREB) in leukemia cell proliferation and acute leukemias.
TL;DR: The role of CREB in hematopoiesis, cell proliferation and acute leukemias is reviewed and it is shown that CREB is overexpressed in blast cells from patients with acute leukedmias.
Journal ArticleDOI
Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants.
Nashat Abumaria,Nashat Abumaria,Adema Ribic,Adema Ribic,Christoph Anacker,Eberhard Fuchs,Eberhard Fuchs,Gabriele Flügge +7 more
TL;DR: In the rat dorsal raphe nucleus (DRN), the nucleus that contains the highest number of 5-HT neurons in the brain, T PH1 mRNA reveals a low level of expression but is detectable both by quantitative real-time PCR and in situ hybridization whereas in the pineal gland (PiG), TPH1 mRNA is strongly expressed.
Journal ArticleDOI
RGS13 Acts as a Nuclear Repressor of CREB
TL;DR: In this article, a member of the Regulator of G protein Signaling (RGS) protein family was identified as a nuclear factor that suppresses CREB-mediated gene expression.
Journal ArticleDOI
Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations.
TL;DR: An overview of the current clinical status, the general mechanism of action of PDE inhibitors in relation to the corticostriatal and hippocampal circuits and several translational challenges are discussed.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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Bonnie E. Lonze,David D. Ginty +1 more