Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
Reads0
Chats0
TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
More filters
Journal ArticleDOI
Plasticity‐related genes in brain development and amygdala‐dependent learning
David E. Ehrlich,S. A. Josselyn +1 more
TL;DR: It is proposed that learning‐dependent activation of BDNF, ERK and CREB signaling in the immature amygdala exaggerates and accelerates neural development, promoting amygdala excitability and environmental sensitivity later in life.
Journal ArticleDOI
The Transcriptional Repressor cAMP Response Element Modulator α Interacts with Histone Deacetylase 1 to Repress Promoter Activity
TL;DR: It is demonstrated that CREMα associates with histone deacetylase (HDAC)1 through its H domain, which is located between the kinase inducible and DNA binding domains, and exerts its repressor activity by a mechanism that involves recruitment of HDAC1, increased deacetyation of histones, and repression of promoter activity.
Journal ArticleDOI
Dynamic modulation of innate immune response by varying dosages of lipopolysaccharide (LPS) in human monocytic cells.
TL;DR: A dynamic modulation of monocytic cells in response to varying dosages of LPS may shed light on the understanding of the dynamic balance that controls pathogenesis and resolution of inflammatory diseases.
Journal ArticleDOI
Regulation of Mucin Gene Expression by CREB via a Nonclassical Retinoic Acid Signaling Pathway
Seung Wook Kim,Jeong Soo Hong,Seung-Hee Ryu,Wen-Cheng Chung,Joo-Heon Yoon,Ja Seok Koo,Ja Seok Koo +6 more
TL;DR: In this article, a non-classical signaling of retinoic acid (RA) on the activation of CREB plays a critical role in regulating the expression of airway epithelial cell differentiation markers.
Journal ArticleDOI
Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner
Susan M. O’Reilly,Martin O. Leonard,Niamh E. Kieran,Katrina M. Comerford,Eoin P. Cummins,Marc Pouliot,Sean B. Lee,Cormac T. Taylor +7 more
TL;DR: Microarray analysis of colon-derived epithelial cells revealed a hypoxia-dependent increase in the expression of amphiregulin, an EGF receptor (EGFR) ligand that activates epithelial proliferation and has been associated with the development of colonic tumors, and support a role for CREB as an HIF-independent hypoxIA-responsive transcription factor in the regulation of intestinal epithelial gene expression.
References
More filters
Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
Related Papers (5)
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals.
Function and Regulation of CREB Family Transcription Factors in the Nervous System
Bonnie E. Lonze,David D. Ginty +1 more