Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
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In mpkCCD cells, long-term regulation of aquaporin-2 by vasopressin occurs independent of protein kinase A and CREB but may involve Epac
Marleen L. A. Kortenoeven,Christiane Trimpert,Michiel van den Brand,Yuedan Li,Jack F.M. Wetzels,Peter M.T. Deen +5 more
TL;DR: The PKA-CRE pathway is involved in the initial rise in AQP2 levels after d DAVP stimulation but not in the long-term effect of dDAVP, which may involve the activation of Epac.
Journal ArticleDOI
Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice
TL;DR: It is suggested that nicotine abstinence promotes long-lasting neuroadaptations in dopaminergic neurocircuits by inducing BDNF production and pCREB levels were significantly elevated and in the VTA significantly decreased as compared with the p CREB levels during the nicotine treatment.
Journal ArticleDOI
Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.
Lei Zhang,Chi Kin Ip,I-Chieh J. Lee,Yue Qi,Felicia Reed,Tim Karl,Jac Kee Low,Ronaldo F. Enriquez,Nicola J. Lee,Nicola J. Lee,Paul A. Baldock,Herbert Herzog,Herbert Herzog +12 more
TL;DR: It is shown that neuropeptide FF receptor-2 signalling promotes thermogenesis via control of NPY expression in the arcuate nucleus, and that it absence in mice leads to a failure of activation of diet-induced thermogenesis and the development of exacerbated obesity.
Journal ArticleDOI
Genome‐wide association analysis identifies the genetic basis of fat deposition in the tails of sheep (Ovis aries)
S.-S. Xu,Xue Ren,Guang-Li Yang,Guang-Li Yang,Xing-Long Xie,Yong-Xin Zhao,Min Zhang,Min Zhang,Z.-Q. Shen,Y.-L. Ren,L. Gao,M. Shen,Juha Kantanen,Meng-Hua Li +13 more
TL;DR: A genome-wide association study using phenotypes and genotypes of two breeds of contrasting tail types of sheep to identify functional genes and variants associated with fat deposition and provides novel insights into genetic mechanisms of fat deposition in the tail of sheep and other mammals.
Journal ArticleDOI
Neuroimmunological communication via CGRP promotes the development of a regulatory phenotype in TLR4-stimulated macrophages.
TL;DR: The results identify neuroimmunological communication through CGRP as a novel costimulatory pathway promoting the development of a regulatory phenotype of TLR4‐stimulated macrophages.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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