Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
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Wnt-Frizzled signalling and the many paths to neural development and adult brain homeostasis.
TL;DR: Key findings showing the pivotal nature of Wnt-Frizzled (FZD) signaling in neurogenesis as revealed by a number of molecular genetic studies using mice and other model organisms are reviewed.
Journal ArticleDOI
CREB Is Activated by Muscle Injury and Promotes Muscle Regeneration
TL;DR: It is shown that CREB phosphorylation and target genes are induced after acute muscle injury and during regeneration due to genetic mutation, and a new physiologic function for CREB is revealed in contributing to skeletal muscle regeneration.
Journal ArticleDOI
Impaired insulin secretion in a mouse model of ataxia telangiectasia
TL;DR: It is shown that young Atm-deficient mice show normal fasting glucose levels and normal insulin sensitivity, however, oral glucose tolerance testing revealed delayed insulin secretion and resulting transient hyperglycemia, indicating a role for ATM in metabolic function.
Journal ArticleDOI
cDNA gene expression profile of rat hippocampus after chronic treatment with antidepressant drugs.
TL;DR: A significant number and homology in gene expression were observed with the three antidepressants and many of the genes were associated with neurogenesis and synaptogenesis, including synaptophysin and neogenin.
Journal ArticleDOI
Adenosine stimulates CREB activation in macrophages via a p38 MAPK-mediated mechanism.
Zoltán Németh,S. Joseph Leibovich,Edwin A. Deitch,Beáta Sperlágh,László Virág,E. Sylvester Vizi,Csaba Szabó,György Haskó,György Haskó +8 more
TL;DR: Some of the immunomodulatory effects of adenosine in macrophages may be explained by its augmenting effect on CREBactivation, indicating that p38 MAPK but not p42/44 MAPK is an upstream mediator of CREB activation.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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