Journal ArticleDOI
Transcriptional regulation by the phosphorylation-dependent factor CREB
Bernhard M. Mayr,Marc Montminy +1 more
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TLDR
The transcription factor CREB functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory, and how is specificity achieved in these signalling pathways?Abstract:
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?read more
Citations
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CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer’s disease
Nana Jin,Wei Qian,Xiaomin Yin,Lan Zhang,Khalid Iqbal,Inge Grundke-Iqbal,Cheng-Xin Gong,Fei Liu +7 more
TL;DR: The findings suggest that overactivation of calpain I caused by calcium overload proteolyses CREB, resulting in a reduction of GLUT3 expression and consequently impairing glucose uptake and metabolism in AD brain.
Journal ArticleDOI
Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.
TL;DR: The approaches that have been employed therapeutically in experimental paradigms to block PDE expression or activity and in turn elevate cyclic nucleotide levels to mediate neuroprotection or neurorepair are reviewed.
Journal ArticleDOI
Controlling Hematopoiesis Through Sumoylation-Dependent Regulation of a GATA Factor
Hsiang-Ying Lee,Kirby D. Johnson,Tohru Fujiwara,Meghan E. Boyer,Shin Il Kim,Emery H. Bresnick +5 more
TL;DR: A mechanism that controls trans-acting factor function in a locus-specific manner, and differentially regulated members of the target gene ensemble reside in distinct subnuclear compartments is illustrated.
Journal ArticleDOI
Synergism between Calcium and Cyclic GMP in Cyclic AMP Response Element-Dependent Transcriptional Regulation Requires Cooperation between CREB and C/EBP-β
Yongchang Chen,Shunhui Zhuang,Stijn Cassenaer,Darren E. Casteel,Tanima Gudi,Gerry R. Boss,Renate B. Pilz +6 more
TL;DR: Calcium-cGMP synergism in neuronal and osteogenic cells which express type II cGMP-dependent protein kinase (G-kinase) and the effect on the fos promoter was mediated by the CRE and proportional to G-kinases activity.
Journal ArticleDOI
Transcriptional Regulation of the Glucose-6-phosphatase Gene by cAMP/Vasoactive Intestinal Peptide in the Intestine ROLE OF HNF4α, CREM, HNF1α, and C/EBPα
TL;DR: The results allow us to identify intestine-specific regulators of the Glc6Pase gene and to improve the understanding of the differences in the regulation of gluconeogenesis in the intestine compared with the liver.
References
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Journal ArticleDOI
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.
Journal ArticleDOI
Phosphorylated CREB binds specifically to the nuclear protein CBP
John C. Chrivia,Roland P. S. Kwok,Ned J.C. Lamb,Masatoshi Hagiwara,Marc Montminy,Richard H. Goodman +5 more
TL;DR: It is proposed that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB, which is activated as a result of phosphorylation by protein kinase A7.
Journal ArticleDOI
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
Azad Bonni,Anne Brunet,Anne E. West,Sandeep Robert Datta,Mari A. Takasu,Michael E. Greenberg +5 more
TL;DR: The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
Journal ArticleDOI
Nuclear protein CBP is a coactivator for the transcription factor CREB
Roland P. S. Kwok,James R. Lundblad,John C. Chrivia,Jane P. Richards,Hans Peter Bächinger,Hans Peter Bächinger,Richard G. Brennan,Stefan G. E. Roberts,Michael R. Green,Richard H. Goodman +9 more
TL;DR: Fluorescence anisotropy measurements are used to define the equi-librium binding parameters of the phosphoCREB:CBP interaction and report here that CBP can activate transcription through a region in its carboxy terminus.
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