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Annika Lindblom
Researcher at Karolinska Institutet
Publications - 16
Citations - 932
Annika Lindblom is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Genome-wide association study & Colorectal cancer. The author has an hindex of 10, co-authored 16 publications receiving 573 citations. Previous affiliations of Annika Lindblom include Karolinska University Hospital & Malmö University.
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Journal ArticleDOI
BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.
Hermela Shimelis,Romy L. S. Mesman,Catharina von Nicolai,Åsa Ehlén,Lucia Guidugli,Charlotte Martin,Fabienne Calléja,Huong Meeks,Emily Hallberg,Jamie Hinton,Jenna Lilyquist,Chunling Hu,Cora M. Aalfs,Kristiina Aittomäki,Irene L. Andrulis,Irene L. Andrulis,Hoda Anton-Culver,Volker Arndt,Matthias W. Beckmann,Javier Benitez,Natalia Bogdanova,Stig E. Bojesen,Stig E. Bojesen,Manjeet K. Bolla,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Paul Brennan,Hermann Brenner,Annegien Broeks,Barbara Brouwers,Thomas Brüning,Barbara Burwinkel,Barbara Burwinkel,Jenny Chang-Claude,Jenny Chang-Claude,Georgia Chenevix-Trench,Ching-Yu Cheng,Ji Yeob Choi,Ji Yeob Choi,J. Margriet Collée,Angela Cox,Simon S. Cross,Kamila Czene,Hatef Darabi,Joe Dennis,Thilo Dörk,Isabel dos-Santos-Silva,Alison M. Dunning,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Henrik Flyger,Montserrat Garcia-Closas,Graham G. Giles,Graham G. Giles,Gord Glendon,Pascal Guénel,Christopher A. Haiman,Per Hall,Ute Hamann,Mikael Hartman,Mikael Hartman,Frans B. L. Hogervorst,Antoinette Hollestelle,John L. Hopper,Hidemi Ito,Anna Jakubowska,Daehee Kang,Daehee Kang,Veli-Matti Kosma,Vessela N. Kristensen,Vessela N. Kristensen,Kah-Nyin Lai,Diether Lambrechts,Loic Le Marchand,Jingmei Li,Annika Lindblom,Artitaya Lophatananon,Jan Lubinski,Eva Machackova,Arto Mannermaa,Sara Margolin,Frederik Marme,Keitaro Matsuo,Hui Miao,Kyriaki Michailidou,Kyriaki Michailidou,Roger L. Milne,Roger L. Milne,Kenneth Muir,Kenneth Muir,Susan L. Neuhausen,Heli Nevanlinna,Janet E. Olson,Curtis Olswold,Jan C. Oosterwijk,Ana Osorio,Paolo Peterlongo,Julian Peto,Pharoah Pd,Katri Pylkäs,Paolo Radice,Muhammad Usman Rashid,Valerie Rhenius,Anja Rudolph,Suleeporn Sangrajrang,Elinor J. Sawyer,Marjanka K. Schmidt,Minouk J. Schoemaker,Caroline M. Seynaeve,Mitul Shah,Chen-Yang Shen,Chen-Yang Shen,Martha J. Shrubsole,Xiao-Ou Shu,Susan L. Slager,Melissa C. Southey,Daniel O. Stram,Anthony J. Swerdlow,Soo H. Teo,Ian Tomlinson,Diana Torres,Diana Torres,Thérèse Truong,Christi J. van Asperen,Lizet E. van der Kolk,Qin Wang,Robert Winqvist,Anna H. Wu,Jyh-Cherng Yu,Wei Zheng,Ying Zheng,Jennifer A. Leary,Logan C. Walker,Lenka Foretova,Florentia Fostira,Kathleen Claes,Liliana Varesco,Setareh Moghadasi,Douglas F. Easton,Amanda B. Spurdle,Peter Devilee,Harry Vrieling,Alvaro N.A. Monteiro,David E. Goldgar,Aura Carreira,Maaike P.G. Vreeswijk,Fergus J. Couch +150 more
TL;DR: Results show how BRCA2 missense variants that influence protein function can confer clinically relevant, moderately increased risks of breast cancer, with potential implications for risk management guidelines in women with these specific variants.
Journal ArticleDOI
Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study
Caroline J. Bull,Joshua A. Bell,Neil Murphy,Eleanor Sanderson,George Davey Smith,Nicholas J. Timpson,Barbara L. Banbury,Demetrius Albanes,Sonja I. Berndt,Stéphane Bézieau,D. Timothy Bishop,Hermann Brenner,Daniel D. Buchanan,Daniel D. Buchanan,Andrea N. Burnett-Hartman,Graham Casey,Sergi Castellví-Bel,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Amanda J. Cross,Albert de la Chapelle,Jane C. Figueiredo,Jane C. Figueiredo,Steven Gallinger,Susan M. Gapstur,Graham G. Giles,Graham G. Giles,Graham G. Giles,Stephen B. Gruber,Andrea Gsur,Jochen Hampe,Heather Hampel,Tabitha A. Harrison,Michael Hoffmeister,Li Hsu,Li Hsu,Wen-Yi Huang,Jeroen R. Huyghe,Mark A. Jenkins,Corinne E. Joshu,Temitope O. Keku,Tilman Kühn,Sun-Seog Kweon,Loic Le Marchand,Christopher I. Li,Li Li,Annika Lindblom,Annika Lindblom,Vicente Martín,Anne M. May,Roger L. Milne,Roger L. Milne,Roger L. Milne,Victor Moreno,Polly A. Newcomb,Polly A. Newcomb,Kenneth Offit,Kenneth Offit,Shuji Ogino,Amanda I. Phipps,Amanda I. Phipps,Elizabeth A. Platz,John D. Potter,Conghui Qu,J. Ramón Quirós,Gad Rennert,Elio Riboli,Lori C. Sakoda,Lori C. Sakoda,Clemens Schafmayer,Robert E. Schoen,Martha L. Slattery,Catherine M. Tangen,Kostas Tsilidis,Kostas Tsilidis,Cornelia M. Ulrich,Fränzel J.B. van Duijnhoven,Bethany Van Guelpen,Kala Visvanathan,Pavel Vodicka,Pavel Vodicka,Pavel Vodicka,Ludmila Vodickova,Ludmila Vodickova,Ludmila Vodickova,Hansong Wang,Emily White,Emily White,Alicja Wolk,Michael O. Woods,Anna H. Wu,Peter T. Campbell,Wei Zheng,Ulrike Peters,Emma E. Vincent,Marc J. Gunter +96 more
TL;DR: Adiposity was associated with numerous metabolic alterations, but none of these explained associations between adiposity and CRC, and it is suggested that higher BMI more greatly raises CRC risk among men, whereas higher WHR more greatly rises CRCrisk among women.
Journal ArticleDOI
A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome
Mark Clendenning,Leigha Senter,Heather Hampel,K. Lagerstedt Robinson,Shuying Sun,Daniel D. Buchanan,Michael Walsh,Mef Nilbert,Jane Green,John D. Potter,Annika Lindblom,A de la Chapelle +11 more
TL;DR: A frequently occurring frame-shift mutation that arose around 1625 years ago is identified in 12 ostensibly unrelated Lynch syndrome patients and Ancestral analysis indicates that this mutation is enriched in individuals with British and Swedish ancestry.
Journal ArticleDOI
Screening for genomic rearrangements of the MMR genes must be included in the routine diagnosis of HNPCC
F Di Fiore,Françoise Charbonnier,Carlos Martín,Stephanie Frerot,Sylviane Olschwang,Qing Wang,Cécile Boisson,Marie-Pierre Buisine,Mef Nilbert,Annika Lindblom,Thierry Frebourg +10 more
TL;DR: It is shown that genomic rearrangements of MSH2 are involved in approximately 20% of the AMS+ HNPCC families without detectable point mutations within MSH 2 or MLH1, and this study was performed using quantitative multiplex PCR of short fluorescent fragments (QMPSF), which can easily detect heterozygous genomic deletions and duplications.
Journal ArticleDOI
The 5′ region of the MSH2 gene involved in hereditary non‐polyposis colorectal cancer contains a high density of recombinogenic sequences
Françoise Charbonnier,Stéphanie Baert-Desurmont,Ping Liang,Frédéric Di Fiore,Cosette Martin,Stephanie Frerot,Sylviane Olschwang,Qing Wang,Marie-Pierre Buisine,Brigitte Gilbert,Mef Nilbert,Annika Lindblom,Thierry Frebourg +12 more
TL;DR: This study demonstrates the heterogeneity of the breakpoints within the MSH2 upstream region and reveals the remarkable density of recombinogenic Alu sequences in this region.