C
Carlos A. Guzmán
Researcher at University of Genoa
Publications - 281
Citations - 10481
Carlos A. Guzmán is an academic researcher from University of Genoa. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 54, co-authored 260 publications receiving 9506 citations. Previous affiliations of Carlos A. Guzmán include Hannover Medical School & Bill & Melinda Gates Foundation.
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Journal ArticleDOI
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education
Niklas K. Björkström,Peggy Riese,Frank Heuts,Sandra Andersson,Cyril Fauriat,Cyril Fauriat,Martin A. Ivarsson,Andreas T. Björklund,Malin Flodström-Tullberg,Jakob Michaëlsson,Martin E. Rottenberg,Carlos A. Guzmán,Hans-Gustaf Ljunggren,Karl-Johan Malmberg +13 more
TL;DR: It is shown that CD56(dim) NK cells continue to differentiate, and the associated functional imprint, occurs independently of NK-cell education by interactions with self-human leukocyte antigen class I ligands and is an essential part of the formation of human NK- cell repertoires.
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Oral Somatic Transgene Vaccination Using Attenuated S. typhimurium
Ayub Darji,Carlos A. Guzmán,Birgit Gerstel,Petra Wachholz,Kenneth N. Timmis,Jürgen Wehland,Trinad Chakraborty,Siegfried Weiss +7 more
TL;DR: A highly versatile system for antigen delivery, identification of protective antigens for vaccination, and efficient generation of antibodies against the product of open reading frames present on virtually any DNA segment is described.
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Establishment of a Real-Time PCR-Based Approach for Accurate Quantification of Bacterial RNA Targets in Water, Using Salmonella as a Model Organism
Axel Fey,Stefan Eichler,Sébastien Flavier,Richard Christen,Manfred G. Höfle,Carlos A. Guzmán +5 more
TL;DR: It is the first time that RNA standards have been successfully used for a precise quantification of the number of RNA molecules in prokaryotes and demonstrates the potential of this approach for determining the presence and metabolic activity of pathogenic bacteria in environmental samples.
Journal ArticleDOI
Humanized mice for modeling human infectious disease: challenges, progress, and outlook.
Nicolas Legrand,Nicolas Legrand,Alexander Ploss,Alexander Ploss,Rudi Balling,Pablo D. Becker,Chiara Borsotti,Nicolas Brezillon,Nicolas Brezillon,Jennifer Debarry,Ype P. de Jong,Ype P. de Jong,Hongkui Deng,Hongkui Deng,James P. Di Santo,James P. Di Santo,Stephanie C. Eisenbarth,Stephanie C. Eisenbarth,Elizabeth E. Eynon,Elizabeth E. Eynon,Richard A. Flavell,Richard A. Flavell,Carlos A. Guzmán,Nicholas D. Huntington,Nicholas D. Huntington,Dina Kremsdorf,Dina Kremsdorf,Michael Manns,Michael Manns,Markus G. Manz,Jean Jacques Mention,Jean Jacques Mention,Michael Ott,Michael Ott,Chozhavendan Rathinam,Chozhavendan Rathinam,Charles M. Rice,Charles M. Rice,Anthony Rongvaux,Anthony Rongvaux,Sean Stevens,Sean Stevens,Hergen Spits,Hergen Spits,Hélène Strick-Marchand,Hélène Strick-Marchand,Hitoshi Takizawa,Anja U. van Lent,Anja U. van Lent,Chengyan Wang,Chengyan Wang,Kees Weijer,Kees Weijer,Tim Willinger,Tim Willinger,Patrick Ziegler +55 more
TL;DR: The potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases, are discussed.
Journal ArticleDOI
Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma
TL;DR: It is shown here, for the first time, that DCs can be directly and specifically transduced in vivo such to induce DNA vaccination against tumors.