Daniel I. Chasman

TL;DR: A two-stage meta-analysis of associations between genotypes from the Illumina exome array and eGFR on the basis of serum creatinine among participants of European ancestry from the CKDGen Consortium identifies novel genes with potential roles in kidney formation.

TL;DR: It is shown that refined HDL phenotyping by NMR spectroscopy can detect known genes of HDL metabolism better than analyses on HDL-C.

TL;DR: Findings underscore the importance of maintaining a healthful diet for the prevention of obesity, particularly for those individuals with a strong genetic predisposition to obesity.

TL;DR: This work integrated migraine GWAS data with high-resolution spatial gene expression data of normal adult brains from the Allen Human Brain Atlas to identify specific brain regions and molecular pathways that are possibly involved in migraine pathophysiology and used the high-confidence genes from the GWAS as a basis to construct local migraine-related co-expression gene networks.

TL;DR: A critical role of DBP in migraine susceptibility and shared biology underlying BP and migraine is supported, while Mendelian randomization suggests that diastolic BP specifically plays a key role in migraines susceptibility.