D
Daniel I. Chasman
Researcher at Brigham and Women's Hospital
Publications - 534
Citations - 85313
Daniel I. Chasman is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 134, co-authored 484 publications receiving 72180 citations. Previous affiliations of Daniel I. Chasman include Washington University in St. Louis & Glenfield Hospital.
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Journal ArticleDOI
Predicting the functional consequences of non-synonymous single nucleotide polymorphisms: structure-based assessment of amino acid variation.
Daniel I. Chasman,R M Adams +1 more
TL;DR: In this article, the potential functional consequences of non-synonymous single nucleotide polymorphisms are analyzed using a structural model and phylogenetic information to derive a selection of structure and sequence-based features serving as indicators of an amino acid polymorphim's effect on function.
Journal ArticleDOI
Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis
Daniel I. Chasman,Guillaume Paré,Samia Mora,J C Hopewell,Gina M. Peloso,Robert Clarke,L. Adrienne Cupples,Anders Hamsten,Sekar Kathiresan,Anders Mälarstig,Jose M. Ordovas,Samuli Ripatti,Alex Parker,Joseph P. Miletich,Paul M. Ridker +14 more
TL;DR: This article performed a genome-wide association study of 17 lipoprotein measures determined by NMR together with LDL, HDL, C, triglycerides, ApoA1, and ApoB in 17,296 women from the Women's Genome Health Study.
Journal ArticleDOI
Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
Daniel I. Chasman,Markus Schürks,Markus Schürks,Verneri Anttila,Verneri Anttila,Boukje de Vries,Ulf Schminke,Lenore J. Launer,Gisela M. Terwindt,Arn M. J. M. van den Maagdenberg,Konstanze Fendrich,Henry Völzke,Florian Ernst,Lyn R. Griffiths,Julie E. Buring,Mikko Kallela,Tobias Freilinger,Christian Kubisch,Paul M. Ridker,Aarno Palotie,Michel D. Ferrari,Wolfgang Hoffmann,Robert Y.L. Zee,Tobias Kurth,Tobias Kurth +24 more
TL;DR: In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899, rs10166942 and rs11172113 were among the top seven associations with migraine, plausibly linking both genes to migraine pathophysiology.
Journal ArticleDOI
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease
Nathan O. Stitziel,Kathleen Stirrups,Nicholas G. D. Masca,Jeanette Erdmann,Paola G. Ferrario,Inke R. Koenig,Peter Weeke,Tom R. Webb,Paul L. Auer,Ursula M. Schick,Yingchang Lu,He Zhang,Marie-Pierre Dubé,Anuj Goel,Martin Farrall,Gina M. Peloso,Hong-Hee Won,Ron Do,Erik P A Van Iperen,Stavroula Kanoni,Jochen Kruppa,Anubha Mahajan,Robert A. Scott,Christina Willenborg,Peter S. Braund,Julian C. van Capelleveen,Alex S. F. Doney,Louise A. Donnelly,Rosanna Asselta,Piera Angelica Merlini,Stefano Duga,Nicola Marziliano,Josh C. Denny,Christian M. Shaffer,Nour Eddine El-Mokhtari,Andre Franke,Omri Gottesman,Stefanie Heilmann,Christian Hengstenberg,Per Hoffmann,Oddgeir L. Holmen,Kristian Hveem,Jan-Håkan Jansson,Karl-Heinz Joeckel,Thorsten Kessler,Jennifer Kriebel,Karl L. Laugwitz,Eirini Marouli,Nicola Martinelli,Mark I. McCarthy,Natalie R. van Zuydam,Christa Meisinger,Tõnu Esko,Evelin Mihailov,Stefan A. Escher,Maris Alver,Susanne Moebus,Andrew D. Morris,Martina Mueller-Nurasyid,Majid Nikpay,Oliviero Olivieri,Louis-Philippe Lemieux Perreault,Alaa AlQarawi,Neil R. Robertson,Karen O. Akinsanya,Dermot F. Reilly,Thomas F. Vogt,Wu Yin,Folkert W. Asselbergs,Charles Kooperberg,Rebecca D. Jackson,Eli A. Stahl,Konstantin Strauch,Tibor V. Varga,Melanie Waldenberger,Lingyao Zeng,Aldi T. Kraja,Chunyu Liu,Georg Ehret,Christopher Newton-Cheh,Daniel I. Chasman,Rajiv Chowdhury,Marco M Ferrario,Ian Ford,J. Wouter Jukema,Frank Kee,Kari Kuulasmaa,Børge G. Nordestgaard,Markus Perola,Danish Saleheen,Naveed Sattar,Praveen Surendran,David-Alexandre Trégouët,Robin Young,Joanna M. M. Howson,Adam S. Butterworth,John Danesh,Diego Ardissino,Erwin P. Bottinger,Raimund Erbel,Paul W. Franks,Domenico Girelli,Alistair S. Hall,G. Kees Hovingh,Adnan Kastrati,Wolfgang Lieb,Thomas Meitinger,William E. Kraus,Svati H. Shah,Ruth McPherson,Marju Orho-Melander,Olle Melander,Andres Metspalu,Colin N. A. Palmer,Annette Peters,Daniel J. Rader,Muredach P. Reilly,Ruth J. F. Loos,Alexander P. Reiner,Dan M. Roden,Jean-Claude Tardif,John R. Thompson,Nicholas J. Wareham,Hugh Watkins,Cristen J. Willer,Sekar Kathiresan,Panos Deloukas,Nilesh J. Samani,Heribert Schunkert +128 more
TL;DR: It was found that carriers of loss-of-function mutations in ANGPTL4 had triglyceride levels that were lower than those among noncarriers; these mutations were also associated with protection from coronary artery disease.
Journal ArticleDOI
Loci Related to Metabolic-Syndrome Pathways Including LEPR,HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study
Paul M. Ridker,Guillaume Paré,Alex Parker,Robert Y.L. Zee,Jacqueline S. Danik,Julie E. Buring,David M Kwiatkowski,Nancy R. Cook,Joseph P. Miletich,Daniel I. Chasman +9 more
TL;DR: Common variation in several genes involved in metabolic and inflammatory regulation have significant effects on CRP levels, consistent with CRP's identification as a useful biomarker of risk for incident vascular disease and diabetes.