D
Daniel I. Chasman
Researcher at Brigham and Women's Hospital
Publications - 534
Citations - 85313
Daniel I. Chasman is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 134, co-authored 484 publications receiving 72180 citations. Previous affiliations of Daniel I. Chasman include Washington University in St. Louis & Glenfield Hospital.
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Journal ArticleDOI
COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials.
Kathryn T. Hall,Julie E. Buring,Kenneth J. Mukamal,M. Vinayaga Moorthy,Peter M. Wayne,Ted J. Kaptchuk,Elisabeth M. Battinelli,Paul M. Ridker,Howard D. Sesso,Stephanie J. Weinstein,Demetrius Albanes,Nancy R. Cook,Daniel I. Chasman +12 more
TL;DR: Pharmacogenetic analysis of catechol-O-methyltransferase (COMT) and cancer prevention in two large randomized trials revealed statistically significant COMT by alpha-tocopherol interaction, such that alpha-ocopherol was beneficial among rs4680 met-allele (28.0%), but not val-alleel (22.8%) homozygotes.
Journal ArticleDOI
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelos Evangelou,Evangelos Evangelou,Helen R. Warren,Helen R. Warren,David Mosen-Ansorena,Borbala Mifsud,Raha Pazoki,He Gao,Georgios Ntritsos,Niki Dimou,Claudia P. Cabrera,Claudia P. Cabrera,Ibrahim Karaman,Fu Liang Ng,Marina Evangelou,K. Witkowska,Evan Tzanis,Jacklyn N. Hellwege,Ayush Giri,D.R. Velez Edwards,Yan V. Sun,Kelly Cho,Kelly Cho,John Michael Gaziano,John Michael Gaziano,Wilson Pwf.,Philip S. Tsao,Csaba P. Kovesdy,Tõnu Esko,Tõnu Esko,Reedik Mägi,Lili Milani,Peter Almgren,Thibaud Boutin,Stéphanie Debette,Jun Ding,Franco Giulianini,Elizabeth G. Holliday,Anne U. Jackson,Ruifang Li-Gao,Lin W-Y.,Jian'an Luan,Massimo Mangino,Massimo Mangino,Christopher Oldmeadow,Bram P. Prins,Yong Qian,Muralidharan Sargurupremraj,Nabi Shah,Nabi Shah,Praveen Surendran,Sébastien Thériault,Sébastien Thériault,Niek Verweij,Niek Verweij,Niek Verweij,Sara M. Willems,Zhao J-H.,Philippe Amouyel,John M. C. Connell,R. de Mutsert,Doney Asf.,Martin Farrall,Martin Farrall,Cristina Menni,Andrew D. Morris,Raymond Noordam,Guillaume Paré,Neil R Poulter,Denis C. Shields,Alice Stanton,Simon Thom,G. Abecasis,Najaf Amin,Dan E. Arking,Kristin L. Ayers,Kristin L. Ayers,Caterina Barbieri,Chiara Batini,J. C. Bis,Tineka Blake,Murielle Bochud,Michael Boehnke,Eric Boerwinkle,Dorret I. Boomsma,Erwin P. Bottinger,Peter S. Braund,Peter S. Braund,Marco Brumat,Archie Campbell,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Ganesh Chauhan,Marina Ciullo,Massimiliano Cocca,Frank H. Collins,Heather J. Cordell,Gary Davies,M. H. de Borst,E.J.C. de Geus,Ian J. Deary,Joris Deelen,Cumhur Y Demirkale,Marcus Dörr,Georg Ehret,Georg Ehret,Roberto Elosua,Stefan Enroth,A.M. Erzurumluoglu,Teresa Ferreira,Mattias Frånberg,Mattias Frånberg,Oscar H. Franco,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,C Gieger,Giorgia Girotto,Anuj Goel,Anuj Goel,Alan J. Gow,Alan J. Gow,Vilmundur Gudnason,Xiuqing Guo,Ulf Gyllensten,Anders Hamsten,T.B. Harris,Sarah E. Harris,Catharina A. Hartman,Aki S. Havulinna,Aki S. Havulinna,Andrew A. Hicks,Edith Hofer,Albert Hofman,Albert Hofman,Hottenga J-J.,Jennifer E. Huffman,Jennifer E. Huffman,Hwang S-J.,Erik Ingelsson,Erik Ingelsson,Alan L. James,Alan L. James,Rick Jansen,Jarvelin M-R.,Roby Joehanes,Åsa Johansson,Andrew D. Johnson,Peter K. Joshi,Pekka Jousilahti,Joop Jukema,Antti Jula,Mika Kähönen,Sekar Kathiresan,Sekar Kathiresan,Sekar Kathiresan,Bernard Keavney,Bernard Keavney,Khaw K-T.,Paul Knekt,Joanne Knight,Ivana Kolcic,Jaspal S. Kooner,Seppo Koskinen,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Maris Laan,Marty Larson,L. J. Launer,Benjamin Lehne,Terho Lehtimäki,Liewald Dcm.,Li Lin,Lars Lind,C M Lindgren,C M Lindgren,C M Lindgren,Yongmei Liu,Loos Rjf.,Loos Rjf.,Lorna M. Lopez,Lorna M. Lopez,Lorna M. Lopez,Yingchang Lu,Lyytikäinen L-P.,Anubha Mahajan,Crysovalanto Mamasoula,J. Marrugat,Jonathan Marten,Y. Milaneschi,Anna Morgan,Andrew P. Morris,Andrew P. Morris,A C Morrison,Peter J. Munson,Mike A. Nalls,Priyanka Nandakumar,Christopher P. Nelson,Christopher P. Nelson,Teemu J. Niiranen,Teemu J. Niiranen,Ilja M. Nolte,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Paul F. O'Reilly,Elin Org,Sandosh Padmanabhan,Sandosh Padmanabhan,Walter Palmas,Aarno Palotie,Aarno Palotie,Aarno Palotie,Alison Pattie,Penninx Bwjh.,Markus Perola,Markus Perola,Markus Perola,Annette Peters,Ozren Polasek,Peter P. Pramstaller,Quang Tri Nguyen,Olli T. Raitakari,Olli T. Raitakari,Meixia Ren,Rainer Rettig,Kenneth Rice,Paul M. Ridker,Paul M. Ridker,Janina S. Ried,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Lynda M. Rose,Jerome I. Rotter,Igor Rudan,Daniela Ruggiero,Yasaman Saba,Cinzia Sala,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Sarin A-P.,Reinhold Schmidt,Helena Schmidt,Nick Shrine,David S. Siscovick,Albert V. Smith,Harold Snieder,Siim Sõber,Rossella Sorice,John M. Starr,David J. Stott,David P. Strachan,Rona J. Strawbridge,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Alexander Teumer,Martin D. Tobin,Maciej Tomaszewski,Maciej Tomaszewski,Daniela Toniolo,Michela Traglia,Stella Trompet,J. Tuomilehto,Christophe Tzourio,André G. Uitterlinden,Ahmad Vaez,Ahmad Vaez,P. J. van der Most,C M van Duijn,Vergnaud A-C.,Germaine C. Verwoert,Veronique Vitart,Uwe Völker,Peter Vollenweider,Dragana Vuckovic,Dragana Vuckovic,Hugh Watkins,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,James F. Wilson,Alan F. Wright,Jie Yao,Tatijana Zemunik,Weihua Zhang,Weihua Zhang,John Attia,Adam S. Butterworth,Adam S. Butterworth,Daniel I. Chasman,Daniel I. Chasman,David Conen,David Conen,Francesco Cucca,Francesco Cucca,John Danesh,John Danesh,Caroline Hayward,Howson Jmm.,Markku Laakso,Edward G. Lakatta,Claudia Langenberg,Olle Melander,Dennis O. Mook-Kanamori,Palmer Cna.,Lorenz Risch,Robert A. Scott,R. J. Scott,Peter S. Sever,Tim D. Spector,P. van der Harst,Nicholas J. Wareham,Eleftheria Zeggini,Daniel Levy,Patricia B. Munroe,Patricia B. Munroe,Christopher Newton-Cheh,Christopher Newton-Cheh,Morris J. Brown,Morris J. Brown,A. Metspalu,Adriana M. Hung,Christopher J. O'Donnell,Todd L. Edwards,Bruce M. Psaty,Bruce M. Psaty,Ioanna Tzoulaki,Ioanna Tzoulaki,Michael R. Barnes,Michael R. Barnes,Louise V. Wain,Louise V. Wain,Paul Elliott,Mark J. Caulfield,Mark J. Caulfield +340 more
TL;DR: In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML and the error has now been corrected in the HTML version of the paper.
Journal ArticleDOI
Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease.
Akintunde O. Akinkuolie,Patrick R. Lawler,Patrick R. Lawler,Patrick R. Lawler,Audrey Y. Chu,Michael P. Caulfield,Jianying Mu,Bo Ding,Fredrik Nyberg,Fredrik Nyberg,Robert J. Glynn,Robert J. Glynn,Paul M. Ridker,Eva Hurt-Camejo,Daniel I. Chasman,Samia Mora +15 more
TL;DR: SPLA2-IIA (group IIA secretory phospholipase A2) plays an integral role in regulating vascular inflammation and is a causal risk factor for cardiovascular disease (CVD).
Journal ArticleDOI
Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.
Hanieh Yaghootkar,Hanieh Yaghootkar,Yiying Zhang,Cassandra N. Spracklen,Tugce Karaderi,Lam Opal Huang,Jonathan P. Bradfield,Claudia Schurmann,Rebecca S. Fine,Michael Preuss,Zoltán Kutalik,Laura B. L. Wittemans,Yingchang Lu,Sophia Metz,Sara M. Willems,Ruifang Li-Gao,Niels Grarup,Shuai Wang,Sophie Molnos,America A. Sandoval-Zárate,Mike A. Nalls,Leslie A. Lange,Jeffrey Haesser,Xiuqing Guo,Leo-Pekka Lyytikäinen,Mary F. Feitosa,Colleen M. Sitlani,Cristina Venturini,Anubha Mahajan,Tim Kacprowski,Carol A. Wang,Daniel I. Chasman,Najaf Amin,Linda Broer,Neil Robertson,Kristin L. Young,Matthew A. Allison,Paul L. Auer,Matthias Blüher,Judith B. Borja,Jette Bork-Jensen,Germán D. Carrasquilla,Paraskevi Christofidou,Ayse Demirkan,Claudia A. Doege,Melissa E. Garcia,Mariaelisa Graff,Kaiying Guo,Hakon Hakonarson,Jaeyoung Hong,Yii-Der Ida Chen,Rebecca D. Jackson,Hermina Jakupović,Pekka Jousilahti,Anne E. Justice,Mika Kähönen,Jorge R. Kizer,Jennifer Kriebel,Charles A. LeDuc,Jin Li,Lars Lind,Jian'an Luan,David A. Mackey,Massimo Mangino,Satu Männistö,Jayne F. Martin Carli,Carolina Medina-Gomez,Dennis O. Mook-Kanamori,Andrew P. Morris,Renée de Mutsert,Matthias Nauck,Ivana Prokic,Craig E. Pennell,Arund D. Pradhan,Bruce M. Psaty,Olli T. Raitakari,Olli T. Raitakari,Robert A. Scott,Tea Skaaby,Konstantin Strauch,Kent D. Taylor,Alexander Teumer,André G. Uitterlinden,Ying Wu,Jie Yao,Mark Walker,Kari E. North,Peter Kovacs,M. Arfan Ikram,Cornelia M. van Duijn,Paul M. Ridker,Stephen J. Lye,Georg Homuth,Erik Ingelsson,Tim D. Spector,Barbara McKnight,Michael A. Province,Terho Lehtimäki,Linda S. Adair,Jerome I. Rotter,Alexander P. Reiner,James G. Wilson,Tamara B. Harris,Samuli Ripatti,Harald Grallert,James B. Meigs,Veikko Salomaa,Torben Hansen,Ko Willems van Dijk,Nicholas J. Wareham,Struan F.A. Grant,Claudia Langenberg,Timothy M. Frayling,Cecilia M. Lindgren,Karen L. Mohlke,Rudolph L. Leibel,Ruth J. F. Loos,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen +118 more
TL;DR: Using in vitro analyses, it is shown that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity.
Journal ArticleDOI
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Amand F. Schmidt,Amand F. Schmidt,Michael V. Holmes,David Preiss,Daniel I. Swerdlow,Daniel I. Swerdlow,Spiros Denaxas,Spiros Denaxas,Ghazaleh Fatemifar,Rupert Faraway,Chris Finan,Dennis Valentine,Zammy Fairhurst-Hunter,Fernando Pires Hartwig,Bernardo L. Horta,Elina Hyppönen,Elina Hyppönen,Christine Power,Max Moldovan,Erik P A Van Iperen,Kees Hovingh,Ilja Demuth,Kristina Norman,Kristina Norman,Elisabeth Steinhagen-Thiessen,Juri Demuth,Lars Bertram,Lars Bertram,Christina M. Lill,Christina M. Lill,Stefan Coassin,Johann Willeit,Stefan Kiechl,Karin Willeit,Karin Willeit,Dan Mason,John Wright,Richard W Morris,Goya Wanamethee,Peter H. Whincup,Yoav Ben-Shlomo,Stela McLachlan,Jackie F. Price,Mika Kivimäki,Catherine Welch,Adelaida Sanchez-Galvez,Pedro Marques-Vidal,Andrew N. Nicolaides,Andrew N. Nicolaides,Andrie G. Panayiotou,N. Charlotte Onland-Moret,Yvonne T. van der Schouw,Giuseppe Matullo,Giovanni Fiorito,Simonetta Guarrera,Carlotta Sacerdote,Nicholas J. Wareham,Claudia Langenberg,Robert A. Scott,Jian'an Luan,Martin Bobak,Sofia Malyutina,Andrzej Pajak,Ruzena Kubinova,Abdonas Tamosiunas,Hynek Pikhart,Niels Grarup,Oluf Pedersen,Torben Hansen,Allan Linneberg,Tine Jess,Jackie A. Cooper,Steve E. Humphries,Murray H. Brilliant,Terrie Kitchner,Hakon Hakonarson,David Carrell,Catherine A. McCarty,Kirchner H. Lester,Eric B. Larson,David R. Crosslin,Mariza de Andrade,Dan M. Roden,Joshua C. Denny,Cara L. Carty,Stephen Hancock,John Attia,Elizabeth G. Holliday,Rodney J. Scott,Peter W. Schofield,Martin O'Donnell,Salim Yusuf,Michael Chong,Guillaume Paré,Pim van der Harst,Pim van der Harst,M. Abdullah Said,Ruben N. Eppinga,Niek Verweij,Harold Snieder,Tim Christen,Dennis O. Mook-Kanamori,Stefan Gustafsson,Lars Lind,Lars Lind,Erik Ingelsson,Erik Ingelsson,Raha Pazoki,Raha Pazoki,Oscar H. Franco,Albert Hofman,André G. Uitterlinden,Abbas Dehghan,Alexander Teumer,Sebastian E. Baumeister,Sebastian E. Baumeister,Marcus Dörr,Markus M. Lerch,Uwe Völker,Henry Völzke,Joey Ward,Jill P. Pell,Tom W. Meade,Ingrid E. Christophersen,Anke H. Maitland-van der Zee,Anke H. Maitland-van der Zee,Ekaterina V. Baranova,Robin Young,Ian Ford,Archie Campbell,Sandosh Padmanabhan,Michiel L. Bots,Diederick E. Grobbee,Philippe Froguel,Philippe Froguel,Dorothée Thuillier,Ronan Roussel,Amélie Bonnefond,Bertrand Cariou,Melissa C. Smart,Yanchun Bao,Meena Kumari,Anubha Mahajan,Jemma C. Hopewell,Sudha Seshadri,Caroline Dale,Rui Bebiano Da Providencia E Costa,Paul M. Ridker,Daniel I. Chasman,Alexander P. Reiner,Marylyn D. Ritchie,Leslie A. Lange,Alex J. Cornish,Sara E. Dobbins,Kari Hemminki,Ben Kinnersley,Marc Sanson,Karim Labreche,Matthias Simon,Melissa L. Bondy,Philip J. Law,Helen E. Speedy,James M. Allan,Ni Li,Molly Went,Niels Weinhold,Gareth J. Morgan,Pieter Sonneveld,Björn Nilsson,Hartmut Goldschmidt,Amit Sud,Andreas Engert,Markus Hansson,Harry Hemingway,Folkert W. Asselbergs,Folkert W. Asselbergs,Riyaz S. Patel,Riyaz S. Patel,Brendan J. Keating,Naveed Sattar,Richard S. Houlston,Juan P. Casas,Aroon D. Hingorani +182 more
TL;DR: Genetic variation at thePCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI, while indicating an increased risk of type 2 diabetes mellitus and no other possible safety concerns were shown.