D
David A. Pearce
Researcher at Northumbria University
Publications - 405
Citations - 20297
David A. Pearce is an academic researcher from Northumbria University. The author has contributed to research in topics: Batten disease & CLN3. The author has an hindex of 72, co-authored 396 publications receiving 18416 citations. Previous affiliations of David A. Pearce include University of Zurich & University of York.
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Journal ArticleDOI
Epithelial sodium channel regulated by aldosterone-induced protein sgk.
Sei-yu Chen,Aditi Bhargava,Luca Mastroberardino,Onno C. Meijer,Jian Wang,Patricia Buse,Gary L. Firestone,François Verrey,David A. Pearce +8 more
TL;DR: Sgk (serum and glucocorticoid-regulated kinase), a member of the serine-threonine kinase family, is identified as an aldosterone-induced regulator of ENaC activity, suggesting that sgk plays a central role in ald testosterone regulation of Na+ absorption and thus in the control of extracellular fluid volume, blood pressure, and sodium homeostasis.
Journal ArticleDOI
Phosphorylation of Nedd4‐2 by Sgk1 regulates epithelial Na+ channel cell surface expression
Christophe Debonneville,Christophe Debonneville,Sandra Y. Flores,Sandra Y. Flores,Elena Kamynina,Pamela J. Plant,Caroline Tauxe,Marc A. Thomas,Carole Münster,Ahmed Chraibi,J. Howard Pratt,Jean-Daniel Horisberger,David A. Pearce,Johannes Loffing,Olivier Staub +14 more
TL;DR: It is shown that phosphorylation of an enzyme involved in the ubiquitylation cascade (Nedd4‐2) controls cell surface density of ENaC and a paradigm for the control of ion channels is proposed.
Journal ArticleDOI
Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element
TL;DR: The distinct physiologic effects mediated by MR and GR may be determined by differential interactions of nonreceptor factors with specific receptor domains at composite response elements at plfG, a 25-base pair composite response element to which both the steroid receptors and transcription factor AP1 can bind.
Journal ArticleDOI
A multi-decade record of high-quality fCO2 data in version 3 of the Surface Ocean CO2 Atlas (SOCAT)
Dorothee C. E. Bakker,Benjamin Pfeil,Benjamin Pfeil,Camilla S. Landa,Camilla S. Landa,Nicolas Metzl,K. O'Brien,Are Olsen,Are Olsen,K. Smith,Catherine E Cosca,S. Harasawa,Stephen D. Jones,Stephen D. Jones,Shin-Ichiro Nakaoka,Yukihiro Nojiri,Ute Schuster,Tobias Steinhoff,Colm Sweeney,Colm Sweeney,Taro Takahashi,Bronte Tilbrook,Bronte Tilbrook,Chisato Wada,Rik Wanninkhof,Simone R. Alin,Carlos F. Balestrini,Leticia Barbero,Leticia Barbero,Nicholas R. Bates,Alejandro A. Bianchi,Frédéric Bonou,Jacqueline Boutin,Yann Bozec,Eugene Burger,Wei-Jun Cai,R. D. Castle,Liqi Chen,Melissa Chierici,Kim I. Currie,Wiley Evans,Charles Featherstone,Richard A. Feely,Agneta Fransson,Catherine Goyet,Naomi Greenwood,Luke Gregor,S. Hankin,Nick J. Hardman-Mountford,Jérôme Harlay,Judith Hauck,Mario Hoppema,Matthew P. Humphreys,Christopher W. Hunt,Betty Huss,J. Severino P. Ibánhez,J. Severino P. Ibánhez,Truls Johannessen,Truls Johannessen,Ralph F. Keeling,Vassilis Kitidis,Arne Körtzinger,Alex Kozyr,Evangelia Krasakopoulou,Akira Kuwata,Peter Landschützer,Siv K. Lauvset,Nathalie Lefèvre,Claire Lo Monaco,Ansley Manke,Jeremy T. Mathis,Liliane Merlivat,Frank J. Millero,Pedro M. S. Monteiro,David R. Munro,Akihiko Murata,Timothy Newberger,Timothy Newberger,Abdirahman M Omar,Tsuneo Ono,K. Paterson,David A. Pearce,Denis Pierrot,Denis Pierrot,Lisa L. Robbins,S. Saito,Joe Salisbury,Reiner Schlitzer,Bernd Schneider,Roland Schweitzer,Rainer Sieger,Ingunn Skjelvan,Kevin F. Sullivan,Kevin F. Sullivan,Stewart C Sutherland,Adrienne J. Sutton,Kazuaki Tadokoro,Maciej Telszewski,Matthias Tuma,Steven van Heuven,Doug Vandemark,Brian Ward,Andrew J. Watson,Suqing Xu +103 more
TL;DR: This ESSD "living data" publication documents the methods and data sets used for the assembly of this new version of the SOCAT data collection and compares these with those used for earlier versions of the data collection.
Journal ArticleDOI
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.
Johannes Loffing,Marija Zecevic,Eric Féraille,Brigitte Kaissling,Carol Asher,Bernard C. Rossier,Gary L. Firestone,David A. Pearce,François Verrey +8 more
TL;DR: It is shown by real-time RT-PCR and immunofluorescence that an aldosterone injection in adrenalectomized rats induces alpha-ENaC subunit expression along the entire ASDN within 2 h, whereas beta- and gamma- ENaC are constitutively expressed.