D
David L. Saunders
Researcher at United States Department of the Army
Publications - 42
Citations - 778
David L. Saunders is an academic researcher from United States Department of the Army. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 13, co-authored 33 publications receiving 517 citations. Previous affiliations of David L. Saunders include University of Maryland, Baltimore & Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples
MalariaGEN,Ambroise D. Ahouidi,Mozam Ali,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Alfred Amambua-Ngwa,Alfred Amambua-Ngwa,Chanaki Amaratunga,Roberto Amato,Roberto Amato,Lucas Amenga-Etego,Ben Andagalu,Tim J. Anderson,Voahangy Andrianaranjaka,Tobias O. Apinjoh,Cristina V. Ariani,Elizabeth A. Ashley,Sarah Auburn,Gordon A. Awandare,Hampate Ba,Vito Baraka,Vito Baraka,Alyssa E. Barry,Alyssa E. Barry,Alyssa E. Barry,Philip Bejon,Gwladys I. Bertin,Maciej F. Boni,Steffen Borrmann,Teun Bousema,Teun Bousema,OraLee H. Branch,Peter C. Bull,Peter C. Bull,George B.J. Busby,Thanat Chookajorn,Kesinee Chotivanich,Antoine Claessens,Antoine Claessens,David J. Conway,Alister Craig,Alister Craig,Umberto D'Alessandro,Souleymane Dama,Nicholas P. J. Day,Brigitte Denis,Mahamadou Diakite,Abdoulaye Djimde,Christiane Dolecek,Arjen M. Dondorp,Chris Drakeley,Eleanor Drury,Patrick E. Duffy,Diego F. Echeverry,Thomas G. Egwang,Berhanu Erko,Rick M. Fairhurst,Abdul Faiz,Caterina A. Fanello,Mark M. Fukuda,Dionicia Gamboa,Anita Ghansah,Lemu Golassa,Sónia Gonçalves,William L Hamilton,William L Hamilton,G. L. Abby Harrison,Lee Hart,Christa Henrichs,Tran Tinh Hien,Catherine A. Hill,Abraham Hodgson,Christina Hubbart,Mallika Imwong,Deus S. Ishengoma,Scott A. Jackson,Christopher G Jacob,Ben Jeffery,Anna E. Jeffreys,Kimberly J. Johnson,Dushyanth Jyothi,Claire Kamaliddin,Edwin Kamau,Mihir Kekre,Krzysztof Kluczynski,Theerarat Kochakarn,Theerarat Kochakarn,Abibatou Konaté,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Myat Phone Kyaw,Pharath Lim,Chanthap Lon,Kovana M. Loua,Oumou Maïga-Ascofaré,Oumou Maïga-Ascofaré,Cinzia Malangone,Magnus Manske,Jutta Marfurt,Kevin Marsh,Kevin Marsh,Mayfong Mayxay,Mayfong Mayxay,Alistair Miles,Alistair Miles,Olivo Miotto,Olivo Miotto,Olivo Miotto,Victor A. Mobegi,Olugbenga A. Mokuolu,Jacqui Montgomery,Ivo Mueller,Paul N. Newton,Thuy Nguyen,Thuy-Nhien Nguyen,Harald Noedl,François Nosten,Rintis Noviyanti,Alexis Nzila,Lynette Isabella Ochola-Oyier,Harold Ocholla,Harold Ocholla,Abraham Oduro,Irene Omedo,Marie A. Onyamboko,Jean-Bosco Ouédraogo,Kolapo Oyebola,Kolapo Oyebola,Richard D. Pearson,Richard D. Pearson,Norbert Peshu,Aung Pyae Phyo,Christopher V. Plowe,Ric N. Price,Ric N. Price,Sasithon Pukrittayakamee,Milijaona Randrianarivelojosia,Julian C. Rayner,Pascal Ringwald,Kirk A. Rockett,Kirk A. Rockett,Katherine Rowlands,Lastenia Ruiz,David L. Saunders,Alex Shayo,Peter Siba,Victoria Simpson,Jim Stalker,Xin-zhuan Su,Colin J. Sutherland,Shannon Takala-Harrison,Livingstone Tavul,Vandana Thathy,Vandana Thathy,Antoinette Tshefu,Federica Verra,Joseph M. Vinetz,Joseph M. Vinetz,Thomas E. Wellems,Jason P. Wendler,Nicholas J. White,Ian J. Wright,William Yavo,Htut Ye +163 more
TL;DR: A new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries aims to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.
Journal ArticleDOI
Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse
Jessica T. Lin,Nicholas J. Hathaway,David L. Saunders,Chanthap Lon,Sujata Balasubramanian,Oksana Kharabora,Panita Gosi,Sabaithip Sriwichai,Laurel B. Kartchner,Char Meng Chuor,Prom Satharath,Charlotte A. Lanteri,Jeffrey A. Bailey,Jonathan J. Juliano +13 more
TL;DR: Deep sequencing at a highly variable region of the P. vivax merozoite surface protein 1 gene revealed impressive diversity-generating 67 unique haplotypes and detecting on average 3.6 cocirculating parasite clones within individuals, compared to 2.1 clones detected by a combination of 3 microsatellite markers.
Journal ArticleDOI
Dose-dependent risk of neutropenia after 7-day courses of artesunate monotherapy in Cambodian patients with acute Plasmodium falciparum malaria.
Delia Bethell,Youry Se,Chanthap Lon,Duong Socheat,David L. Saunders,Paktiya Teja-Isavadharm,Phisit Khemawoot,Sea Darapiseth,Jessica T. Lin,Sabaithip Sriwichai,Worachet Kuntawungin,Sittidech Surasri,Sue J. Lee,Ses Sarim,Stuart D. Tyner,Bryan Smith,Mark M. Fukuda +16 more
TL;DR: The artemisinin derivatives remain one of the safest classes of antimalarial drugs, but this study demonstrates that the dosing limit may have been reached, and future experimental dosing studies must be designed with care, because the safety of such regimens can no longer be assumed.
Journal ArticleDOI
Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis.
Daniel A. Pfeffer,Benedikt Ley,Rosalind E. Howes,Rosalind E. Howes,Patrick Adu,Mohammad Shafiul Alam,Pooja Bansil,Yap Boum,Yap Boum,Marcelo A M Brito,Pimlak Charoenkwan,Archie C. A. Clements,Archie C. A. Clements,Liwang Cui,Zeshuai Deng,Ochaka Julie Egesie,Fe Espino,Michael E. von Fricken,Muzamil Mahdi Abdel Hamid,Yongshu He,Gisela Henriques,Wasif A. Khan,Nimol Khim,Saorin Kim,Marcus V. G. Lacerda,Chanthap Lon,Asrat Hailu Mekuria,Didier Menard,Wuelton Marcelo Monteiro,François Nosten,François Nosten,Nwe Nwe Oo,Sampa Pal,Duangdao Palasuwan,Sunil Parikh,Ayodhia Pitaloka Pasaribu,Jeanne Rini Poespoprodjo,David J. Price,Arantxa Roca-Feltrer,Michelle E. Roh,David L. Saunders,David L. Saunders,Michele D. Spring,Inge Sutanto,Kamala Ley-Thriemer,Thomas A. Weppelmann,Lorenz von Seidlein,Ari W. Satyagraha,Germana Bancone,Germana Bancone,Gonzalo J. Domingo,Ric N. Price,Ric N. Price,Ric N. Price +53 more
TL;DR: There is substantial variation in G6PD measurements by spectrophotometry between sites, likely due to variability in laboratory methods, with possible contribution of unmeasured population factors.
Journal ArticleDOI
Efficacy of Two versus Three-Day Regimens of Dihydroartemisinin-Piperaquine for Uncomplicated Malaria in Military Personnel in Northern Cambodia: An Open-Label Randomized Trial
Chanthap Lon,Jessica E. Manning,Pattaraporn Vanachayangkul,Mary So,Darapiseth Sea,Youry Se,Panita Gosi,Charlotte A. Lanteri,Suwanna Chaorattanakawee,Sabaithip Sriwichai,Soklyda Chann,Worachet Kuntawunginn,Nillawan Buathong,Samon Nou,Douglas S. Walsh,Stuart D. Tyner,Jonathan J. Juliano,Jessica T. Lin,Michele D. Spring,Delia Bethell,Jaranit Kaewkungwal,Douglas B. Tang,Char Meng Chuor,Prom Satharath,David L. Saunders +24 more
TL;DR: In the brief period since introduction of dihydroartemisinin-piperaquine, there is early evidence suggesting declining efficacy relative to previous reports, which warrants improved monitoring of clinical outcomes and follow-up, given few available alternative drugs.