G
Gillian Hunt
Researcher at University of the Witwatersrand
Publications - 56
Citations - 2321
Gillian Hunt is an academic researcher from University of the Witwatersrand. The author has contributed to research in topics: Population & Drug resistance. The author has an hindex of 24, co-authored 54 publications receiving 1960 citations. Previous affiliations of Gillian Hunt include National Health Laboratory Service.
Papers
More filters
Journal ArticleDOI
HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression analysis
Ravindra K. Gupta,John Gregson,Neil Parkin,Hiwot Haile-Selassie,Amilcar Tanuri,Liliana Andrade Forero,Pontiano Kaleebu,Christine Watera,Avelin F. Aghokeng,Nicholus Mutenda,Janet Dzangare,San Hone,Zaw Zaw Hang,Judith Garcia,Zully Garcia,Paola Marchorro,Enrique Beteta,Amalia Giron,Raph L. Hamers,Seth C Inzaule,Lisa M. Frenkel,Lisa M. Frenkel,Michael H. Chung,Tulio de Oliveira,Tulio de Oliveira,Deenan Pillay,Kogie Naidoo,Kogie Naidoo,Ayesha B. M. Kharsany,Ruthiran Kugathasan,Teresa Cutino,Gillian Hunt,Santiago Avila Rios,Meg Doherty,Michael R. Jordan,Michael R. Jordan,Silvia Bertagnolio +36 more
TL;DR: In 2016, the prevalence of pretreatment NNRTI resistance was near WHO's 10% threshold for changing first-line ART in southern and eastern Africa and Latin America, underscoring the need for routine national HIV drug-resistance surveillance and review of national policies for first- line ART regimen composition.
Journal ArticleDOI
Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study
John Gregson,Michele Tang,Nicaise Ndembi,Raph L. Hamers,Soo-Yon Rhee,Vincent C. Marconi,Lameck Diero,Katherine A Brooks,Kristof Theys,Tobias F. Rinke de Wit,Monica B. Arruda,Frederico Garcia,Susana Monge,Huldrych F. Günthard,Christopher J. Hoffmann,Phyllis J. Kanki,N. Kumarasamy,Bernard Kerschberger,Orna Mor,Charlotte Charpentier,Eva Todesco,Casper Rokx,Luuk Gras,Elias K Helvas,Henry Sunpath,Domenico Di Carlo,Antonio Antinori,Massimo Andreoni,Alessandra Latini,Cristina Mussini,Avelin F. Aghokeng,Anders Sönnerborg,Ujjwal Neogi,William J Fessel,Simon Agolory,Chunfu Yang,José Luis Santiago Blanco,James M Juma,Erasmus Smit,Daniel Schmidt,Christine Watera,Juliet Asio,Wilford Kurungi,Anna Tostevin,Tal El-Hay,Nathan Clumeck,Dominique Goedhals,Cloete van Vuuren,Philip A Bester,Caroline A. Sabin,Irene Mukui,Maria Mercedes Santoro,Carlo Federico Perno,Gillian Hunt,Lynn Morris,Ricardo Jorge Camacho,Tulio de Oliveira,Deenan Pillay,Eugene Schulter,Akio Murakami-Ogasawara,Gustavo Reyes-Teran,Karla Romero,Santiago Avila-Rios,Sunee Sirivichayakul,Kiat Ruxrungtham,Suwanna Mekprasan,David Dunn,Pontiano Kaleebu,Elliot Raizes,Rami Kantor,Robert W. Shafer,Ravindra K. Gupta +71 more
TL;DR: A global assessment of drug resistance after virological failure with first-line tenofovir-containing ART, defined as presence of K65R/N or K70E/G/Q mutations in the reverse transcriptase ( RT ) gene.
Journal ArticleDOI
Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis
Soo-Yon Rhee,José Luis Santiago Blanco,Michael R. Jordan,Jonathan Taylor,Philippe Lemey,Vici Varghese,Raph L. Hamers,Silvia Bertagnolio,Tobias F. Rinke de Wit,Avelin F. Aghokeng,Jan Albert,Radko Avi,Santiago Ávila-Ríos,Pascal O. Bessong,James Brooks,Charles A. Boucher,Zabrina L. Brumme,Michael P. Busch,Hermann Bussmann,Marie Laure Chaix,Bum Sik Chin,Toni T. D’Aquin,Cillian De Gascun,Anne Derache,Diane Descamps,Alaka Deshpande,Cyrille F. Djoko,Susan H. Eshleman,Hervé Fleury,Pierre Frange,Seiichiro Fujisaki,P. Richard Harrigan,Junko Hattori,África Holguín,Gillian Hunt,Hiroshi Ichimura,Pontiano Kaleebu,David Katzenstein,Sasisopin Kiertiburanakul,Jerome H. Kim,Sung Soon Kim,Yanpeng Li,Irja Lutsar,Lynn Morris,Nicaise Ndembi,Kee Peng Ng,Ramesh S. Paranjape,Martine Peeters,Mario Poljak,Matthew Price,Manon Ragonnet-Cronin,Gustavo Reyes-Terán,Morgane Rolland,Sunee Sirivichayakul,Davey M. Smith,Marcelo A. Soares,Vincent Soriano,Deogratius Ssemwanga,Maja Stanojevic,Mariane A. Stefani,Wataru Sugiura,Somnuek Sungkanuparph,Amilcar Tanuri,Kok Keng Tee,Hong-Ha M. Truong,David A. M. C. van de Vijver,Nicole Vidal,Chunfu Yang,Rongge Yang,Gonzalo Yebra,John P. A. Ioannidis,Anne-Mieke Vandamme,Robert W. Shafer +72 more
TL;DR: Most TDR strains in SSA and SSEA arose independently, suggesting that ARV regimens with a high genetic barrier to resistance combined with improved patient adherence may mitigate TDR increases by reducing the generation of new ARV-resistant strains.
Journal ArticleDOI
Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis
Joris Hemelaar,Ramyiadarsini Elangovan,Jason Yun,Leslie Dickson-Tetteh,Isabella Fleminger,Shona Kirtley,Brian G. Williams,Eleanor Gouws-Williams,Peter D. Ghys,Alash'le Abimiku,Simon Agwale,Chris P. Archibald,Boaz Avidor,María Gabriela Barbás,Françoise Barré-Sinoussi,Banson Barugahare,El Hadj Belabbes,Silvia Bertagnolio,Deborah L. Birx,Aleksei F Bobkov,James Brandful,Helba Bredell,Catherine A. Brennan,James Brooks,Marie Bruckova,Luigi Buonaguro,Franco M. Buonaguro,Stefano Buttò,Anne Buvé,Mary S. Campbell,Jean K. Carr,Alex Carrera,Manuel Gómez Carrillo,Connie Celum,Beth Chaplin,Macarthur Charles,Dimitrios Chatzidimitriou,Zhiwei Chen,Katsumi Chijiwa,David Cooper,Philip Cunningham,Anoumou Y. Dagnra,Cillian De Gascun,Julia del Amo,Elena Delgado,Ursula Dietrich,Dominic M. Dwyer,Dennis Ellenberger,Barbara Ensoli,Max Essex,Feng Gao,Hervé Fleury,Peter N. Fonjungo,Vincent Foulongne,Deepak A Gadkari,Federico García,Roger Garsia,Guy Michel Gershy-Damet,Judith R. Glynn,Ruth Goodall,Zehava Grossman,Monick Lindenmeyer-Guimarães,Beatrice H. Hahn,Raph L. Hamers,Osamah Hamouda,Ray Handema,Xiang He,Joshua T. Herbeck,David D. Ho,África Holguín,Mina C. Hosseinipour,Gillian Hunt,Masahiko Ito,Mohamed Ali Bel Hadj Kacem,Erin M. Kahle,Pontiano Kaleebu,Marcia L. Kalish,Adeeba Kamarulzaman,Chun Kang,Phyllis J. Kanki,Edward Karamov,Jean-Claude Karasi,Kayitesi Kayitenkore,Tony Kelleher,Dwip Kitayaporn,Leondios G. Kostrikis,Claudia Kücherer,Claudia Lara,Thomas Leitner,Kirsi Liitsola,J.R. Lingappa,Marek Linka,Ivette Lorenzana de Rivera,Vladimir Lukashov,Shlomo Maayan,Luzia Mayr,Francine E. McCutchan,Nicolas Meda,Elisabeth Menu,Fred Mhalu,Doreen Mloka,John L. Mokili,Brigitte Montes,Orna Mor,Mariza G. Morgado,Fausta Mosha,Awatef Moussi,James I. Mullins,Rafael Nájera,Mejda Nasr,Nicaise Ndembi,Joel R. Neilson,Vivek R. Nerurkar,Florian Neuhann,Claudine Nolte,Vlad Novitsky,Philippe Nyambi,Marianna Ofner,Fem J Paladin,Anna Papa,Jean Pape,Neil Parkin,Christopher M. Parry,Martine Peeters,Alexandra Pelletier,Lucía Pérez-Álvarez,Deenan Pillay,Angie N Pinto,Trinh Duy Quang,Cecilia Rademeyer,Filimone Raikanikoda,Mark A. Rayfield,Jean-Marc Reynes,Tobias F. Rinke de Wit,Kenneth E. Robbins,Morgane Rolland,Christine Rousseau,Jesus Salazar-Gonzales,Hanan Salem,Mika Salminen,Horacio Salomon,Paul Sandstrom,Mario L. Santiago,Abdoulaye Dieng Sarr,Bryan Schroeder,Michel Segondy,Philippe Selhorst,Sylvester Sempala,Jean Servais,Ansari Shaik,Yiming Shao,Amine Slim,Marcelo A. Soares,Elijah M. Songok,Debbie Stewart,Julie Stokes,Shambavi Subbarao,Ruengpung Sutthent,Jun Takehisa,Amilcar Tanuri,Kok Keng Tee,Kiran Thapa,Michael M. Thomson,Tyna Tran,Willy Urassa,Hiroshi Ushijima,Philippe Van de Perre,Guido van der Groen,Kristel Van Laethem,Joep J. van Oosterhout,Ard van Sighem,Eric Van Wijngaerden,Anne-Mieke Vandamme,Jurgen Vercauteren,Nicole Vidal,Lesley Wallace,Carolyn Williamson,Dawit Wolday,Jianqing Xu,Chunfu Yang,Linqi Zhang,Rong Zhang +181 more
TL;DR: The distribution of HIV-1 subtypes and recombinants changed over time in countries, regions, and globally as well as at a global level during 2005-15, where subtype B increased, subtypes A and D were stable, and subtypes C and G and CRF02_AG decreased.
Journal ArticleDOI
Antiretroviral drug resistance surveillance among drug-naive HIV-1-infected individuals in Gauteng Province, South Africa in 2002 and 2004.
Visva Pillay,Johanna Ledwaba,Gillian Hunt,Mpho Rakgotho,Beverly Singh,Lindiwe Makubalo,Diane E Bennett,Adrian Puren,Lynn Morris +8 more
TL;DR: Using the threshold survey, resistance prevalence overall and for each drug class in 2002 and 2004 was <5% for the Gauteng province of South Africa, suggesting that surveillance should be conducted annually among untreated populations to determine if this increases with time.