J
Jan Koster
Researcher at University of Amsterdam
Publications - 238
Citations - 25156
Jan Koster is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Neuroblastoma & Cancer. The author has an hindex of 59, co-authored 206 publications receiving 20459 citations. Previous affiliations of Jan Koster include Netherlands Cancer Institute & Royal College of Surgeons in Ireland.
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Journal ArticleDOI
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
Dominik Sturm,Hendrik Witt,Hendrik Witt,Volker Hovestadt,Dong Anh Khuong-Quang,David T.W. Jones,Carolin Konermann,Elke Pfaff,Martje Tönjes,Martin Sill,Sebastian Bender,Marcel Kool,Marc Zapatka,Natalia Becker,Manuela Zucknick,Thomas Hielscher,Xiaoyang Liu,Adam M. Fontebasso,Marina Ryzhova,Steffen Albrecht,Karine Jacob,Marietta Wolter,Martin Ebinger,Martin U. Schuhmann,Timothy E. Van Meter,Michael C. Frühwald,Holger Hauch,Arnulf Pekrun,Bernhard Radlwimmer,Tim Niehues,Gregor Von Komorowski,Matthias Dürken,Andreas E. Kulozik,Jenny Madden,Andrew M. Donson,Nicholas K. Foreman,Rachid Drissi,Maryam Fouladi,Wolfram Scheurlen,Andreas von Deimling,Andreas von Deimling,Camelia M. Monoranu,Wolfgang Roggendorf,Christel Herold-Mende,Andreas Unterberg,Christof M. Kramm,Jörg Felsberg,Christian Hartmann,Benedikt Wiestler,Wolfgang Wick,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Anders Lindroth,Jeremy Schwartzentruber,Damien Faury,Adam Fleming,Magdalena Zakrzewska,Pawel P. Liberski,Krzysztof Zakrzewski,Peter Hauser,Miklós Garami,Almos Klekner,László Bognár,Sorana Morrissy,Florence M.G. Cavalli,Michael D. Taylor,Peter van Sluis,Jan Koster,Rogier Versteeg,Richard Volckmann,Tom Mikkelsen,Kenneth Aldape,Guido Reifenberger,V. Peter Collins,Jacek Majewski,Andrey Korshunov,Peter Lichter,Christoph Plass,Nada Jabado,Stefan M. Pfister,Stefan M. Pfister +82 more
TL;DR: It is demonstrated that each H3F3A mutation defines an epigenetic subgroup of GBM with a distinct global methylation pattern, and that they are mutually exclusive with IDH1 mutations, which characterize a third mutation-defined subgroup.
Journal ArticleDOI
Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
Marc van de Wetering,Hayley E. Francies,Joshua M. Francis,Joshua M. Francis,Gergana Bounova,Francesco Iorio,Apollo Pronk,Winan J. van Houdt,Joost van Gorp,Amaro Taylor-Weiner,Lennart Kester,Anne McLaren-Douglas,Joyce Blokker,Sridevi Jaksani,Sina Bartfeld,Richard Volckman,Peter van Sluis,Vivian S. W. Li,Sara Seepo,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Kristian Cibulskis,Scott L. Carter,Scott L. Carter,Aaron McKenna,Michael S. Lawrence,Lee Lichtenstein,Chip Stewart,Jan Koster,Rogier Versteeg,Alexander van Oudenaarden,Julio Saez-Rodriguez,Robert G.J. Vries,Gad Getz,Gad Getz,Lodewyk F. A. Wessels,Michael R. Stratton,Ultan McDermott,Matthew Meyerson,Matthew Meyerson,Mathew J. Garnett,Hans Clevers +41 more
TL;DR: Tumor organoids are amenable to high-throughput drug screens allowing detection of gene-drug associations and may fill the gap between cancer genetics and patient trials, complement cell-line- and xenograft-based drug studies, and allow personalized therapy design.
Journal ArticleDOI
The landscape of genomic alterations across childhood cancers
Susanne Gröbner,Barbara C. Worst,Joachim Weischenfeldt,Joachim Weischenfeldt,Ivo Buchhalter,Kortine Kleinheinz,Vasilisa A. Rudneva,Pascal Johann,Gnana Prakash Balasubramanian,Maia Segura-Wang,Sebastian Brabetz,Sebastian Bender,Barbara Hutter,Dominik Sturm,Elke Pfaff,Daniel Hübschmann,Gideon Zipprich,Michael Heinold,Michael Heinold,Jürgen Eils,Christian Lawerenz,Serap Erkek,Sander Lambo,Sebastian M. Waszak,Claudia Blattmann,Arndt Borkhardt,Arndt Borkhardt,Michaela Kuhlen,Michaela Kuhlen,Angelika Eggert,Angelika Eggert,Simone Fulda,Manfred Gessler,Jenny Wegert,Roland Kappler,Roland Kappler,Daniel Baumhoer,Stefan Burdach,Stefan Burdach,Renate Kirschner-Schwabe,Renate Kirschner-Schwabe,Udo Kontny,Andreas E. Kulozik,Andreas E. Kulozik,Dietmar R. Lohmann,Simone Hettmer,Cornelia Eckert,Cornelia Eckert,Stefan S. Bielack,Michaela Nathrath,Michaela Nathrath,Charlotte M. Niemeyer,Charlotte M. Niemeyer,Gunther Richter,Gunther Richter,Johannes H. Schulte,Johannes H. Schulte,Reiner Siebert,Frank Westermann,Jan J. Molenaar,Gilles Vassal,Hendrik Witt,Peter Lichter,Ursula Weber,Roland Eils,Roland Eils,Andrey Korshunov,Olaf Witt,Stefan Pfister,Guido Reifenberger,J Felsberg,Christof von Kalle,Manfred Schmidt,Cynthia Bartholomä,Michael Taylor,David T. W. Jones,Natalie Jäger,Korbel Jo,Adrian M. Stütz,Tobias Rausch,Bernhard Radlwimmer,Marie-Laure Yaspo,Hans Lehrach,Hans-Jörg Warnatz,Pablo Landgraf,Benedikt Brors,Marc Zapatka,Marc Zapatka,Susanne Wagner,Susanne Wagner,Andrea Haake,Julia Richter,Gesine Richter,Gesine Richter,Chris Lawerenz,Jules Kerssemakers,Christina Jaeger-Schmidt,Ingrid Scholz,Anke K. Bergmann,Christoph Borst,Birgit Burkhardt,Alexander Claviez,Martin Dreyling,Martin Dreyling,Sonja Eberth,Hermann Einsele,Norbert Frickhofen,Siegfried Haas,Martin-Leo Hansmann,Dennis Karsch,Michael Kneba,Jasmin Lisfeld,Luisa Mantovani-Löffler,Marius Rohde,German Ott,Christina Stadler,Peter Staib,Stephan Stilgenbauer,Lorenz Trümper,Thorsten Zenz,Dieter Kube,Ralf Küppers,Marc A. Weniger,Michael Hummel,Wolfram Klapper,Ulrike Kostezka,Dido Lenze,Peter Möller,Andreas Rosenwald,Monika Szczepanowski,Ole Ammerpohl,Sietse M. Aukema,Vera Binder,Jessica I. Hoell,Ellen Leich,Cristina López,Inga Nagel,Jordan Pischimariov,Philip Rosenstiel,Markus Schilhabel,Stefan Schreiber,Inga Vater,Rabea Wagener,Stephan H. Bernhart,Hans Binder,Gero Doose,Steve Hoffmann,Lydia Hopp,Helene Kretzmer,Markus Kreuz,David Langenberger,Markus Loeffler,Maciej Rosolowski,Matthias Schlesner,Peter F. Stadler,Stephanie Sungalee,Christian P. Kratz,Cornelis M. van Tilburg,Christof M. Kramm,Gudrun Fleischhack,Gudrun Fleischhack,Uta Dirksen,Stefan Rutkowski,Michael C. Frühwald,Katja von Hoff,Stephan Wolf,Thomas Klingebiel,Thomas Klingebiel,Ewa Koscielniak,Jan Koster,Adam C. Resnick,Jinghui Zhang,Yanling Liu,Xin Zhou,Angela J. Waanders,Danny A. Zwijnenburg,Pichai Raman,Ursula D. Weber,Paul A. Northcott,Kristian W. Pajtler,Marcel Kool,Rosario M. Piro,Jan O. Korbel,David T.W. Jones,Lukas Chavez,Stefan M. Pfister +185 more
TL;DR: The data suggest that 7–8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.
Journal ArticleDOI
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
Marcel Kool,Andrey Korshunov,Marc Remke,Marc Remke,David T.W. Jones,Maria Schlanstein,Paul A. Northcott,Yoon Jae Cho,Jan Koster,Antoinette Y N Schouten-van Meeteren,Dannis G. van Vuurden,Steven C. Clifford,Torsten Pietsch,André O. von Bueren,Stefan Rutkowski,Martin G. McCabe,Martin G. McCabe,V. Peter Collins,Magnus Bäcklund,Christine Haberler,Franck Bourdeaut,Olivier Delattre,François Doz,David W. Ellison,Richard J. Gilbertson,Scott L. Pomeroy,Michael D. Taylor,Peter Lichter,Stefan M. Pfister,Stefan M. Pfister +29 more
TL;DR: A meta-analysis of all molecular and clinical data of 550 medulloblastomas brought together from seven independent studies shows how distinct the molecular subtypes are with respect to their transcriptome, DNA copy-number aberrations, demographics, and survival.
Journal ArticleDOI
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups
Kristian W. Pajtler,Kristian W. Pajtler,Hendrik Witt,Martin Sill,David T.W. Jones,Volker Hovestadt,Fabian Kratochwil,Khalida Wani,Ruth G. Tatevossian,Chandanamali Punchihewa,Pascal Johann,Jüri Reimand,Hans-Jörg Warnatz,Marina Ryzhova,Steve Mack,Vijay Ramaswamy,David Capper,David Capper,Leonille Schweizer,Leonille Schweizer,Laura Sieber,Andrea Wittmann,Zhiqin Huang,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Daniel W. Fults,Helen Toledano,Smadar Avigad,Lindsey M. Hoffman,Andrew M. Donson,Nicholas K. Foreman,Ekkehard Hewer,Karel Zitterbart,Mark R. Gilbert,Terri S. Armstrong,Terri S. Armstrong,Nalin Gupta,Jeffrey C. Allen,Matthias A. Karajannis,David Zagzag,Martin Hasselblatt,Andreas E. Kulozik,Olaf Witt,V. Peter Collins,Katja von Hoff,Stefan Rutkowski,Torsten Pietsch,Gary D. Bader,Marie-Laure Yaspo,Andreas von Deimling,Andreas von Deimling,Peter Lichter,Michael D. Taylor,Richard J. Gilbertson,David W. Ellison,Kenneth Aldape,Andrey Korshunov,Andrey Korshunov,Marcel Kool,Stefan M. Pfister +61 more
TL;DR: The molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.