J
John M. Pezzuto
Researcher at Long Island University
Publications - 599
Citations - 38474
John M. Pezzuto is an academic researcher from Long Island University. The author has contributed to research in topics: Cancer & Resveratrol. The author has an hindex of 88, co-authored 588 publications receiving 35901 citations. Previous affiliations of John M. Pezzuto include Purdue University & Bandung Institute of Technology.
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Journal ArticleDOI
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Journal ArticleDOI
Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells
Kotha Subbaramaiah,Wen Jing Chung,Pedro Michaluart,Nitin T. Telang,Tadashi Tanabe,Hiroyasu Inoue,Mei-Shiang Jang,John M. Pezzuto,Andrew J. Dannenberg +8 more
TL;DR: It is found that resveratrol also directly inhibited the activity of COX-2, a phenolic antioxidant found in grapes and other food products, which is likely to be important for understanding the anti-cancer and anti-inflammatory properties of resver atrol.
Journal Article
Cancer chemopreventive activity of resveratrol.
M Jang,John M. Pezzuto +1 more
TL;DR: Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a naturally occurring compound shown to inhibit carcinogen-induced preneoplastic lesion formation in mouse mammary organ culture and tumorigenesis in the two-stage mouse skin model as discussed by the authors.
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Plant-derived anticancer agents
TL;DR: A proposal is put forth to create a cancer chemoprevention drug formulation for utilization on a widespread basis by the general population, and the composition of the formulation should improve over time.
Journal Article
Evaluation of the antioxidant potential of natural products.
Sang Kook Lee,Z H Mbwambo,Chung Hs,Lumonadio Luyengi,E. J. C. Gamez,Rajendra G. Mehta,A. D. Kinghorn,John M. Pezzuto +7 more
TL;DR: Of these substances, the hydroxystilbenes piceatannol and transresveratrol have thus far been shown to inhibit carcinogen-induced preneoplastic lesion formation in the mouse mammary gland organ culture model.