M
Meera Venkatesan
Researcher at University of Maryland, Baltimore
Publications - 31
Citations - 3256
Meera Venkatesan is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 20, co-authored 28 publications receiving 2705 citations. Previous affiliations of Meera Venkatesan include Johns Hopkins University.
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Journal ArticleDOI
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Elizabeth A. Ashley,Mehul Dhorda,Rick M. Fairhurst,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Mao S,Sam B,Chantha Sopha,Char Meng Chuor,Chea Nguon,Siv Sovannaroth,Sasithon Pukrittayakamee,Podjanee Jittamala,Kesinee Chotivanich,K Chutasmit,C Suchatsoonthorn,R Runcharoen,Tran Tinh Hien,Nguyen Thuy-Nhien,Thanh Nv,Nguyen Hoan Phu,Ye Htut,Han Kt,Kyin Hla Aye,Olugbenga A. Mokuolu,Rasaq Olaosebikan,Olaleke Oluwasegun Folaranmi,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Paul N. Newton,M A Onyamboko,Caterina I. Fanello,Antoinette Tshefu,Neelima Mishra,Neena Valecha,Aung Pyae Phyo,François Nosten,Yi P,Rupam Tripura,Steffen Borrmann,Mahfudh Bashraheil,Judy Peshu,M A Faiz,Aniruddha Ghose,M A Hossain,Rasheda Samad,M. R. Rahman,Manal Hasan,Ashraful Islam,Olivo Miotto,Roberto Amato,Bronwyn MacInnis,Jim Stalker,Dominic P. Kwiatkowski,Zbynek Bozdech,Atthanee Jeeyapant,Phaik Yeong Cheah,Tharisara Sakulthaew,Jeremy Chalk,Benjamas Intharabut,Kamolrat Silamut,Lee Sj,Benchawan Vihokhern,Chanon Kunasol,Mallika Imwong,Joel Tarning,Taylor Wj,Shunmay Yeung,Charles J. Woodrow,Jennifer A. Flegg,Debashish Das,Jennifer L. Smith,Meera Venkatesan,Christopher V. Plowe,Kasia Stepniewska,Philippe J Guerin,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas J. White +82 more
TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Journal ArticleDOI
Polymorphisms in Plasmodium falciparum chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine
Meera Venkatesan,Nahla B Gadalla,Kasia Stepniewska,Prabin Dahal,Christian Nsanzabana,Clarissa Moriera,Ric N. Price,Andreas Mårtensson,Philip J. Rosenthal,Grant Dorsey,Colin J. Sutherland,Philippe J Guerin,Timothy M. E. Davis,Didier Menard,Ishag Adam,George O. Ademowo,Cesar Arze,Frederick N. Baliraine,Nicole Berens-Riha,Anders Björkman,Steffen Borrmann,Francesco Checchi,Meghna Desai,Mehul Dhorda,Abdoulaye Djimde,Badria B. El-Sayed,Teferi Eshetu,Frederick Eyase,Catherine O. Falade,Jean-François Faucher,Gabrielle Fröberg,Anastasia Grivoyannis,Sally Hamour,Sandrine Houzé,Jacob D. Johnson,Erasmus Kamugisha,Simon Kariuki,Jean-René Kiechel,Fred Kironde,Fred Kironde,Poul-Erik Kofoed,Jacques Lebras,Maja Malmberg,Maja Malmberg,Leah Mwai,Leah Mwai,Billy Ngasala,François Nosten,Samuel L. Nsobya,Alexis Nzila,Alexis Nzila,Mary C. Oguike,Sabina Dahlström Otienoburu,Bernhards Ogutu,Jean-Bosco Ouédraogo,Patrice Piola,Patrice Piola,Lars Rombo,Birgit Schramm,A. Fabrice Some,Julie Thwing,Johan Ursing,Rina P. M. Wong,Ahmed Zeynudin,Issaka Zongo,Christopher V. Plowe,Carol Hopkins Sibley,Carol Hopkins Sibley +67 more
TL;DR: Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine.
Journal ArticleDOI
Association of Plasmodium falciparum kelch13 R561H genotypes with delayed parasite clearance in Rwanda: an open-label, single-arm, multicentre, therapeutic efficacy study.
Aline Uwimana,Noella Umulisa,Meera Venkatesan,Samaly S. Svigel,Zhiyong Zhou,Tharcisse Munyaneza,Rafiki M. Habimana,Anicet Rucogoza,Leah F. Moriarty,Ryan Sandford,Emily Piercefield,Ira F. Goldman,Bryan Ezema,Eldin Talundzic,M. Andreína Pacheco,Ananias A. Escalante,Daniel Ngamije,Jean Louis N. Mangala,Michee Kabera,Kaendi Munguti,Monique Murindahabi,William R. Brieger,Clarisse Musanabaganwa,Leon Mutesa,Venkatachalam Udhayakumar,Aimable Mbituyumuremyi,Eric S. Halsey,Naomi W. Lucchi +27 more
TL;DR: In this paper, the efficacy of artemether-lumefantrine and genetic characterisation of Pfkelch13 alleles and their association with treatment outcomes were investigated in three Rwandan sites: Masaka, Rukara, and Bugarama.
Journal ArticleDOI
Independent Emergence of the Plasmodium falciparum Kelch Propeller Domain Mutant Allele C580Y in Guyana
Stella M. Chenet,Sheila Okoth,Curtis S. Huber,Javin Chandrabose,Naomi W. Lucchi,Eldin Talundzic,Karanchand Krishnalall,Nicolas Ceron,Lise Musset,Alexandre Macedo de Oliveira,Meera Venkatesan,Reyaud Rahman,John W. Barnwell,Venkatachalam Udhayakumar +13 more
TL;DR: These molecular data demonstrate independent emergence of the C580Y K13 mutant allele in Guyana, where resistance alleles to previously used drugs are fixed and continued molecular surveillance and periodic assessment of the therapeutic efficacy of artemisinin-based combination therapy are warranted.
Journal ArticleDOI
Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites.
Seif Shekalaghe,Mastidia Rutaihwa,Peter F. Billingsley,Mwajuma Chemba,Claudia Daubenberger,Eric R. James,Maximillian Mpina,Omar Juma,Tobias Schindler,Eric Huber,Anusha Gunasekera,Anita Manoj,Beatus Simon,Elizabeth Saverino,L. W. Preston Church,Cornelus C. Hermsen,Robert W. Sauerwein,Christopher V. Plowe,Meera Venkatesan,Philip Sasi,Omar Lweno,Paul Mutani,Ali Hamad,Ali Mohammed,Alwisa Urassa,Tutu Mzee,Debbie Padilla,Adam Ruben,B. Kim Lee Sim,Marcel Tanner,Salim Abdulla,Stephen L. Hoffman +31 more
TL;DR: A double-blind, placebo-controlled trial to assess safety and infectivity of PfSPZ Challenge in adult male Tanzanians was conducted in this paper, where volunteers were injected with 10,000 or 25,000 Pf sporozoites or normal saline.