P
Peter Pickkers
Researcher at Radboud University Nijmegen
Publications - 551
Citations - 24686
Peter Pickkers is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Sepsis & Intensive care. The author has an hindex of 70, co-authored 501 publications receiving 17971 citations. Previous affiliations of Peter Pickkers include Radboud University Nijmegen Medical Centre & Waikato Hospital.
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Assessment of the worldwide burden of critical illness: The Intensive Care Over Nations (ICON) audit
Jean Louis Vincent,John C. Marshall,Silvio A. Ñamendys-Silva,Bruno François,Ignacio Martin-Loeches,Jeffrey Lipman,Konrad Reinhart,Massimo Antonelli,Peter Pickkers,Hassane Njimi,Edgar Jimenez,Yasser Sakr +11 more
TL;DR: In this article, the authors did an international audit of ICU patients worldwide and assessed variations between hospitals and countries in terms of the ICU mortality, showing that sepsis remains a major health problem worldwide, associated with high mortality rates in all countries.
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Decontamination of the Digestive Tract and Oropharynx in ICU Patients
TL;DR: In an ICU population in which the mortality rate associated with standard care was 27.5% at day 28, the rate was reduced by an estimated 3.5 percentage points with SDD and by 2.9 percentage pointsWith SOD, according to a random-effects logistic-regression model.
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A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1
Janesh Pillay,Vera M. Kamp,Els van Hoffen,Tjaakje Visser,Tamar Tak,Jan-Willem J. Lammers,Laurien H. Ulfman,Luke P. H. Leenen,Peter Pickkers,Leo Koenderman +9 more
TL;DR: It is demonstrated that suppression of T cell function can be accomplished by a subset of human neutrophils that can be systemically induced in response to acute inflammation.
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A Unified Theory of Sepsis-Induced Acute Kidney Injury: Inflammation, microcirculatory dysfunction, bioenergetics and the tubular cell adaptation to injury
Hernando Gomez,Can Ince,Daniel De Backer,Peter Pickkers,Didier Payen,John Hotchkiss,John A. Kellum +6 more
TL;DR: It is proposed that the interplay between inflammation and oxidative stress, microvascular dysfunction, and the adaptive response of the tubular epithelial cell to the septic insult is mostly adaptive in origin, that it is driven by mitochondria, and that it ultimately results in and explains the clinical phenotype of sepsis-induced AKI.
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COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup.
Mitra K. Nadim,Lui G. Forni,Lui G. Forni,Ravindra L. Mehta,Michael J. Connor,Kathleen D. Liu,Marlies Ostermann,Thomas Rimmelé,Alexander Zarbock,Samira Bell,Azra Bihorac,Vincenzo Cantaluppi,Eric Hoste,Faeq Husain-Syed,Michael J. Germain,Stuart L. Goldstein,Shruti Gupta,Michael Joannidis,Kianoush Kashani,Jay L. Koyner,Matthieu Legrand,Nuttha Lumlertgul,Sumit Mohan,Neesh Pannu,Zhiyong Peng,Xose L. Perez-Fernandez,Peter Pickkers,John R. Prowle,Thiago Reis,Nattachai Srisawat,Nattachai Srisawat,Ashita Tolwani,Anitha Vijayan,Gianluca Villa,Li Yang,Claudio Ronco,John A. Kellum +36 more
TL;DR: This Consensus Statement from the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI and for areas of future research, with the aim of improving understanding of the underlying processes and outcomes for patients with CO VID- 19 AKI.