P
Philip C. Calder
Researcher at University of Southampton
Publications - 808
Citations - 70822
Philip C. Calder is an academic researcher from University of Southampton. The author has contributed to research in topics: Polyunsaturated fatty acid & Eicosapentaenoic acid. The author has an hindex of 125, co-authored 747 publications receiving 59110 citations. Previous affiliations of Philip C. Calder include Southampton General Hospital & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Dietary glutamine enhances cytokine production by murine macrophages.
TL;DR: Increasing the amount of glutamine in the murine diet enhances the ability of macrophages to respond to stimulation, at least in terms of cytokine production, to suggest that increasing the availability of glutamines orally could promote immune responses involving macrophage-derived cytokines.
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Supplementation with a Fish Oil-Enriched, High-Protein Medical Food Leads to Rapid Incorporation of EPA into White Blood Cells and Modulates Immune Responses within One Week in Healthy Men and Women
Joyce Faber,M. Berkhout,Arjan P. Vos,John W.C. Sijben,Philip C. Calder,Johan Garssen,Ardy van Helvoort +6 more
TL;DR: Nutritional supplementation with a fish oil-enriched medical food significantly increased the percentage of EPA in phospholipids of WBC within 1 wk and ex vivo immune responsiveness to LPS increased significantly, which hold promise for novel applications such as fast-acting nutritional interventions in cancer patients.
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Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged men
TL;DR: Data from the present study suggest that marine oil providing 1.8 g of EPA plus 0.3g DHA/day is not sufficient to demonstrate marked effects on cardiovascular risk factors in healthy middle-aged men, although there may be a slight anti-inflammatory effect as indicated by the decrease in sICAM-1.
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Fatty acids and atopic disease.
TL;DR: Because of the central role of 4-series LTs in asthma and other diseases, there is great interest in developing pharmacological agents which inhibit the release of arachidonic acid.
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Gene polymorphisms, inflammatory diseases and cancer
TL;DR: The influence of polymorphisms associated with differential cytokine expression on disease susceptibility is currently of much interest as discussed by the authors, with a focus on associations with susceptibility to benign immunologically-mediated diseases, including a number of gut diseases.