P
Philippe Goyette
Researcher at Montreal Heart Institute
Publications - 63
Citations - 18635
Philippe Goyette is an academic researcher from Montreal Heart Institute. The author has contributed to research in topics: Genome-wide association study & Inflammatory bowel disease. The author has an hindex of 32, co-authored 56 publications receiving 16915 citations. Previous affiliations of Philippe Goyette include Université de Montréal.
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Journal ArticleDOI
A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease
Eleonora A. M. Festen,Philippe Goyette,Todd Green,Gabrielle Boucher,Claudine Beauchamp,Gosia Trynka,Patrick Dubois,Caroline Lagacé,Pieter C. F. Stokkers,Daan W. Hommes,Donatella Barisani,Orazio Palmieri,Vito Annese,David A. van Heel,Rinse K. Weersma,Mark J. Daly,Mark J. Daly,Cisca Wijmenga,John D. Rioux +18 more
TL;DR: The combined analysis of the two datasets provided the power, lacking in the individual GWAS for single diseases, to detect shared loci with a relatively small effect and identified four shared risk loci: PTPN2, IL18RAP, TAGAP, and PUS10.
Journal ArticleDOI
Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis
Mélissa Beaudoin,Philippe Goyette,Gabrielle Boucher,Ken Sin Lo,Manuel A. Rivas,Christine Stevens,Azadeh Alikashani,Martin Ladouceur,David Ellinghaus,Leif Törkvist,Gautam Goel,Caroline Lagacé,Vito Annese,Alain Bitton,Jakob Begun,S Brant,Francesca Bresso,Judy H. Cho,Richard H. Duerr,Jonas Halfvarson,Dermot P.B. McGovern,Graham L. Radford-Smith,Stefan Schreiber,Philip Schumm,Yashoda Sharma,Mark S. Silverberg,Rinse K. Weersma,Mauro D'Amato,Severine Vermeire,Andre Franke,Guillaume Lettre,Guillaume Lettre,Ramnik J. Xavier,Ramnik J. Xavier,Mark J. Daly,John D. Rioux,John D. Rioux +36 more
TL;DR: It is suggested that rare variants in genes identified by genome-wide association in UC are unlikely to contribute significantly to the overall variance for the disease, and are expected to help focus functional studies of the corresponding disease loci.
Journal ArticleDOI
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.
Dan E. Arking,M. Juhani Junttila,M. Juhani Junttila,Philippe Goyette,Adriana Huertas-Vazquez,Mark Eijgelsheim,Marieke T. Blom,Christopher Newton-Cheh,Christopher Newton-Cheh,Kyndaron Reinier,Carmen Teodorescu,Audrey Uy-Evanado,Naima Carter-Monroe,Kari S. Kaikkonen,Marja-Leena Kortelainen,Gabrielle Boucher,Caroline Lagacé,Anna Moes,Xiaoqing Zhao,Frank D. Kolodgie,Fernando Rivadeneira,Albert Hofman,Jacqueline C.M. Witteman,André G. Uitterlinden,Roos F. Marsman,Raha Pazoki,Abdennasser Bardai,Rudolph W. Koster,Abbas Dehghan,Shih-Jen Hwang,Pallav Bhatnagar,Wendy S. Post,Gina Hilton,Ronald J. Prineas,Man Li,Anna Köttgen,Georg Ehret,Georg Ehret,Eric Boerwinkle,Josef Coresh,W. H. Linda Kao,Bruce M. Psaty,Bruce M. Psaty,Gordon F. Tomaselli,Nona Sotoodehnia,David S. Siscovick,Greg L. Burke,Eduardo Marbán,Peter M. Spooner,L. Adrienne Cupples,L. Adrienne Cupples,Jonathan Jui,Karen Gunson,Y. Antero Kesäniemi,Arthur A.M. Wilde,Jean-Claude Tardif,Christopher J. O'Donnell,Connie R. Bezzina,Renu Virmani,Bruno H. Stricker,Hanno L. Tan,Christine M. Albert,Aravinda Chakravarti,John D. Rioux,Heikki V. Huikuri,Sumeet S. Chugh +65 more
TL;DR: A genome-wide association meta-analysis is performed in 1,283 SCD cases and >20,000 control individuals of European ancestry to identify the BAZ2B locus as associated with SCD and test the role of 49 SNPs previously implicated in modulating electrocardiographic traits (QRS, QT, and RR intervals).
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Elizabeth K. Speliotes,Elizabeth K. Speliotes,Cristen J. Willer,Sonja I. Berndt,Keri L. Monda,Gudmar Thorleifsson,Anne U. Jackson,Hana Lango Allen,Cecilia M. Lindgren,Jian'an Luan,Reedik Maegi,Joshua C. Randall,Sailaja Vedantam,Thomas W. Winkler,Lu Qi,Lu Qi,Tsegaselassie Workalemahu,Iris M. Heid,Valgerdur Steinthorsdottir,Heather M. Stringham,Michael N. Weedon,Eleanor Wheeler,Andrew R. Wood,Teresa Ferreira,Robert J. Weyant,Ayellet V. Segrè,Ayellet V. Segrè,Karol Estrada,Liming Liang,James Nemesh,James Nemesh,Ju-Hyun Park,Stefan Gustafsson,Tuomas O. Kilpelaenen,Jian Yang,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Tõnu Esko,Mary F. Feitosa,Zoltán Kutalik,Massimo Mangino,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,André Scherag,Albert V. Smith,Ryan P. Welch,Jing Hua Zhao,Katja K.H. Aben,Devin Absher,Najaf Amin,Anna L. Dixon,Eva Fisher,Nicole L. Glazer,Michael E. Goddard,Nancy L. Heard-Costa,Volker Hoesel,Jouke-Jan Hottenga,Åsa Johansson,Åsa Johansson,Toby Johnson,Shamika Ketkar,Claudia Lamina,Shengxu Li,Miriam F. Moffatt,Richard H. Myers,Narisu Narisu,John R. B. Perry,Marjolein Peters,Michael Preuss,Samuli Ripatti,Fernando Rivadeneira,Camilla H. Sandholt,Laura J. Scott,Nicholas J. Timpson,Jonathan Tyrer,Sophie van Wingerden,Richard M. Watanabe,Charles C. White,Fredrik Wiklund,Christina Barlassina,Daniel I. Chasman,Daniel I. Chasman,Mark E. Cooper,John-Olov Jansson,Robert Lawrence,Niina Pellikka,Inga Prokopenko,Jianxin Shi,Elisabeth Thiering,Helene Alavere,Maria Teresa Sciarrone Alibrandi,Peter Almgren,Alice M. Arnold,Thor Aspelund,Larry D. Atwood,Beverley Balkau,Anthony J. Balmforth,Amanda J. Bennett,Yoav Ben-Shlomo,Richard N. Bergman,Sven Bergmann,Heike Biebermann,Alexandra I. F. Blakemore,Tanja Boes,Lori L. Bonnycastle,Stefan R. Bornstein,Morris Brown,Thomas A. Buchanan,Fabio Busonero,Harry Campbell,Francesco P. Cappuccio,Christine Cavalcanti-Proença,Christine Cavalcanti-Proença,Yii-Der Ida Chen,Chih-Mei Chen,Peter S. Chines,Robert Clarke,Lachlan J. M. Coin,John M. C. Connell,Ian N. M. Day,Martin den Heijer,Jubao Duan,Shah Ebrahim,Paul Elliott,Roberto Elosua,Gudny Eiriksdottir,Michael R. Erdos,Johan G. Eriksson,Maurizio F. Facheris,Stephan B. Felix,Pamela Fischer-Posovszky,Aaron R. Folsom,Aaron R. Folsom,Nele Friedrich,Nelson B. Freimer,Mao Fu,Stefan Gaget,Stefan Gaget,Pablo V. Gejman,Eco J. C. de Geus,Christian Gieger,Anette P. Gjesing,Anuj Goel,Philippe Goyette,Harald Grallert,Juergen Graessler,Danielle M. Greenawalt,Christopher J. Groves,Vilmundur Gudnason,Candace Guiducci,Anna-Liisa Hartikainen,Neelam Hassanali,Alistair S. Hall,Aki S. Havulinna,Caroline Hayward,Andrew C. Heath,Christian Hengstenberg,Andrew A. Hicks,Anke Hinney,Albert Hofman,Georg Homuth,Jennie Hui,Wilmar Igl,Carlos Iribarren,Carlos Iribarren,Bo Isomaa,Kevin B. Jacobs,Ivonne Jarick,Elizabeth S. Jewell,Ulrich John,Torben Jørgensen,Pekka Jousilahti,Antti Jula,Marika Kaakinen,Eero Kajantie,Lee M. Kaplan,Sekar Kathiresan,Johannes Kettunen,Leena Kinnunen,Joshua W. Knowles,Ivana Kolcic,Inke R. Koenig,Seppo Koskinen,Peter Kovacs,Johanna Kuusisto,Peter Kraft,Kirsti Kvaløy,Jaana Laitinen,Olivier Lantieri,Chiara Lanzani,Lenore J. Launer,Cécile Lecoeur,Cécile Lecoeur,Terho Lehtimaeki,Guillaume Lettre,Guillaume Lettre,Jianjun Liu,Marja-Liisa Lokki,Mattias Lorentzon,Robert Luben,Barbara Ludwig,Paolo Manunta,Diana Marek,Michel Marre,Nicholas G. Martin,Wendy L. McArdle,Anne McCarthy,Barbara McKnight,Thomas Meitinger,Olle Melander,David Meyre,David Meyre,Kristian Midthjell,Grant W. Montgomery,Mario A. Morken,Andrew P. Morris,Rosanda Mulić,Julius S. Ngwa,Mari Nelis,Mari Nelis,Matt Neville,Dale R. Nyholt,Christopher J. O'Donnell,Stephen O'Rahilly,Ken K. Ong,Ben A. Oostra,Guillaume Paré,Alex N. Parker,Markus Perola,Irene Pichler,Kirsi H. Pietilaeinen,Carl G. P. Platou,Ozren Polasek,Anneli Pouta,Suzanne Rafelt,Olli T. Raitakari,Nigel W. Rayner,Martin Ridderstråle,Winfried Rief,Aimo Ruokonen,Neil Robertson,Peter Rzehak,Veikko Salomaa,Alan R. Sanders,Manjinder S. Sandhu,Manjinder S. Sandhu,Serena Sanna,Jouko Saramies,Markku J. Savolainen,Susann Scherag,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,Kaisa Silander,Juha Sinisalo,David S. Siscovick,Jan Smit,Nicole Soranzo,Nicole Soranzo,Ulla Sovio,Jonathan Stephens,Jonathan Stephens,Ida Surakka,Amy J. Swift,Mari-Liis Tammesoo,Jean-Claude Tardif,Jean-Claude Tardif,Maris Teder-Laving,Tanya M. Teslovich,John R. Thompson,John R. Thompson,Brian Thomson,Anke Toenjes,Tiinamaija Tuomi,Joyce B. J. van Meurs,Gert-Jan B. van Ommen,Vincent Vatin,Vincent Vatin,Jorma S. A. Viikari,Jorma S. A. Viikari,Sophie Visvikis-Siest,Veronique Vitart,Carla I. G. Vogel,Benjamin F. Voight,Lindsay L. Waite,Henri Wallaschofski,G. Bragi Walters,Elisabeth Widen,Susanna Wiegand,Sarah H. Wild,Gonneke Willemsen,Daniel R. Witte,Jacqueline C. M. Witteman,Jianfeng Xu,Qunyuan Zhang,Lina Zgaga,Andreas Ziegler,Paavo Zitting,John Beilby,I. Sadaf Farooqi,Johannes Hebebrand,Heikki V. Huikuri,Alan James,Mika Kaehoenen,Douglas F. Levinson,Fabio Macciardi,Fabio Macciardi,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Paul M. Ridker,Paul M. Ridker,Michael Stumvoll,Jacques S. Beckmann,Heiner Boeing,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,Francis S. Collins,L. Adrienne Cupples,George Davey Smith,Jeanette Erdmann,Philippe Froguel,Philippe Froguel,Philippe Froguel,Henrik Greonberg,Ulf Gyllensten,Per Hall,Torben Hansen,Tamara B. Harris,Andrew T. Hattersley,Richard B. Hayes,Joachim Heinrich,Frank B. Hu,Frank B. Hu,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Jaakko Kaprio,Fredrik Karpe,Kay-Tee Khaw,Lambertus A. Kiemeney,Heiko Krude,Markku Laakso,Debbie A Lawlor,Andres Metspalu,Patricia B. Munroe,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Oluf Pedersen,Oluf Pedersen,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Annette Peters,Peter P. Pramstaller,Thomas Quertermous,Thomas Reinehr,Aila Rissanen,Igor Rudan,Igor Rudan,Nilesh J. Samani,Peter Schwarz,Alan R. Shuldiner,Tim D. Spector,Jaakko Tuomilehto,Manuela Uda,André G. Uitterlinden,Timo T. Valle,Martin Wabitsch,Gerard Waeber,Nicholas J. Wareham,Hugh Watkins,James F. Wilson,Alan F. Wright,M. Carola Zillikens,Nilanjan Chatterjee,Steven A. McCarroll,Shaun Purcell,Eric E. Schadt,Peter M. Visscher,Themistocles L. Assimes,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Leif Groop,Talin Haritunians,David J. Hunter,David J. Hunter,Robert C. Kaplan,Karen L. Mohlke,Jeffrey R. O'Connell,Leena Peltonen,David Schlessinger,David P. Strachan,Cornelia M. van Duijn,H-Erich Wichmann,Timothy M. Frayling,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Gonçalo R. Abecasis,Inês Barroso,Inês Barroso,Michael Boehnke,Kari Stefansson,Kari Stefansson,Kari E. North,Mark I. McCarthy,Joel N. Hirschhorn,Erik Ingelsson,Ruth J. F. Loos +413 more
TL;DR: In this article, the authors examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs and up to 125,931 additional individuals.
Journal ArticleDOI
Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
Eleonora A. M. Festen,Philippe Goyette,Regan Scott,Vito Annese,Alexandra Zhernakova,Jing Lian,C. Lefebvre,Steven R. Brant,Judy H. Cho,Mark S. Silverberg,Kent D. Taylor,Dirk J. de Jong,Pieter C. F. Stokkers,Dermot P. McGovern,Orazio Palmieri,Jean-Paul Achkar,Ramnik J. Xavier,Mark J. Daly,Richard H. Duerr,Cisca Wijmenga,Rinse K. Weersma,John D. Rioux +21 more
TL;DR: A strong association for the IL2/IL21 locus with UC was found, which confirms it as a general susceptibility locus for inflammatory disease.