S
Sandra Lai
Researcher at National Research Council
Publications - 19
Citations - 5754
Sandra Lai is an academic researcher from National Research Council. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 16, co-authored 18 publications receiving 5307 citations. Previous affiliations of Sandra Lai include National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.
Angelo Scuteri,Serena Sanna,Wei-Min Chen,Manuela Uda,Giuseppe Albai,James B. Strait,Samer S. Najjar,Ramaiah Nagaraja,Marco Orru,Gianluca Usala,Mariano Dei,Sandra Lai,Andrea Maschio,Fabio Busonero,Antonella Mulas,Georg Ehret,Ashley A Fink,Alan B. Weder,Richard S. Cooper,Pilar Galan,Aravinda Chakravarti,David Schlessinger,Antonio Cao,Edward G. Lakatta,Gonçalo R. Abecasis +24 more
TL;DR: In this paper, a genome-wide association scan was conducted to identify genetic variants associated with obesity-related quantitative traits in the genetically isolated population of Sardinia, and the results showed that common genetic variants in the FTO gene are associated with substantial changes in body weight.
Journal ArticleDOI
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia
Manuela Uda,Renzo Galanello,Serena Sanna,Guillaume Lettre,Guillaume Lettre,Vijay G. Sankaran,Wei-Min Chen,Gianluca Usala,Fabio Busonero,Andrea Maschio,Giuseppe Albai,Maria Grazia Piras,Natascia Sestu,Sandra Lai,Mariano Dei,Antonella Mulas,Laura Crisponi,Silvia Naitza,Isadora Asunis,Manila Deiana,Ramaiah Nagaraja,Lucia Perseu,Stefania Satta,Maria Dolores Cipollina,Carla Sollaino,Paolo Moi,Joel N. Hirschhorn,Joel N. Hirschhorn,Stuart H. Orkin,G. Abecasis,David Schlessinger,Antonio Cao +31 more
TL;DR: It is indicated that BCL11A variants, by modulating HbF levels, act as an important ameliorating factor of the β-thalassemia phenotype, and it is likely they could helpAmeliorate other hemoglobin disorders.
Journal ArticleDOI
Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians
Giuseppe Pilia,Wei-Min Chen,Angelo Scuteri,Marco Orru,Giuseppe Albai,Mariano Dei,Sandra Lai,Gianluca Usala,Monica Lai,Paola Loi,Cinzia Mameli,Loredana Vacca,Manila Deiana,Nazario Olla,Marco Masala,Antonio Cao,Samer S. Najjar,Antonio Terracciano,Timur Nedorezov,Alexei A. Sharov,Alan B. Zonderman,Gonçalo R. Abecasis,Paul T. Costa,Edward G. Lakatta,David Schlessinger +24 more
TL;DR: Significant evidence for heritability of many medically important traits, including cardiovascular function and personality is found, and evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits.
Journal ArticleDOI
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
John R. B. Perry,Felix R. Day,Cathy E. Elks,Patrick Sulem,Deborah J. Thompson,Teresa Ferreira,Chunyan He,Daniel I. Chasman,Tõnu Esko,Tõnu Esko,Gudmar Thorleifsson,Eva Albrecht,Wei Ang,Tanguy Corre,Tanguy Corre,Diana L. Cousminer,Bjarke Feenstra,Nora Franceschini,Andrea Ganna,Andrew D. Johnson,Sanela Kjellqvist,Kathryn L. Lunetta,George McMahon,Ilja M. Nolte,Lavinia Paternoster,Eleonora Porcu,Albert V. Smith,Lisette Stolk,Alexander Teumer,Natalia Tšernikova,Emmi Tikkanen,Sheila Ulivi,Erin K. Wagner,Najaf Amin,Laura J. Bierut,Enda M. Byrne,Enda M. Byrne,Jouke-Jan Hottenga,Daniel L. Koller,Massimo Mangino,Tune H. Pers,Tune H. Pers,Tune H. Pers,Laura M. Yerges-Armstrong,Jing Hua Zhao,Irene L. Andrulis,Hoda Anton-Culver,Femke Atsma,Stefania Bandinelli,Matthias W. Beckmann,Javier Benitez,Carl Blomqvist,Stig E. Bojesen,Manjeet K. Bolla,Bernardo Bonanni,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Julie E. Buring,Jenny Chang-Claude,Stephen J. Chanock,Jinhui Chen,Georgia Chenevix-Trench,J. Margriet Collée,Fergus J. Couch,David Couper,Andrea D. Coviello,Angela Cox,Kamila Czene,Adamo Pio D'Adamo,George Davey Smith,Immaculata De Vivo,Ellen W. Demerath,Joe Dennis,Peter Devilee,Aida Karina Dieffenbach,Alison M. Dunning,Gudny Eiriksdottir,Johan G. Eriksson,Johan G. Eriksson,Peter A. Fasching,Luigi Ferrucci,Dieter Flesch-Janys,Henrik Flyger,Tatiana Foroud,Lude Franke,Melissa E. Garcia,Montserrat Garcia-Closas,Frank Geller,Eco de Geus,Graham G. Giles,Graham G. Giles,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Vilmundur Gudnason,Pascal Guénel,Suiqun Guo,Per Hall,Ute Hamann,Robin Haring,Catharina A. Hartman,Andrew C. Heath,Albert Hofman,Maartje J. Hooning,John L. Hopper,Frank B. Hu,David J. Hunter,David Karasik,Douglas P. Kiel,Julia A. Knight,Veli-Matti Kosma,Zoltán Kutalik,Zoltán Kutalik,Sandra Lai,Diether Lambrechts,Annika Lindblom,Reedik Mägi,Patrik K. E. Magnusson,Arto Mannermaa,Nicholas G. Martin,Gisli Masson,Patrick F. McArdle,Wendy L. McArdle,Mads Melbye,Mads Melbye,Kyriaki Michailidou,Evelin Mihailov,Lili Milani,Roger L. Milne,Roger L. Milne,Heli Nevanlinna,Patrick Neven,Ellen A. Nohr,Albertine J. Oldehinkel,Ben A. Oostra,Aarno Palotie,Aarno Palotie,Aarno Palotie,Munro Peacock,Nancy L. Pedersen,Paolo Peterlongo,Julian Peto,Paul D.P. Pharoah,Dirkje S. Postma,Anneli Pouta,Anneli Pouta,Katri Pylkäs,Paolo Radice,Susan M. Ring,Fernando Rivadeneira,Antonietta Robino,Lynda M. Rose,Anja Rudolph,Veikko Salomaa,Serena Sanna,David Schlessinger,Marjanka K. Schmidt,Mellissa C. Southey,Ulla Sovio,Ulla Sovio,Meir J. Stampfer,Doris Stöckl,Anna Maria Storniolo,Nicholas J. Timpson,Jonathan Tyrer,Jenny A. Visser,Peter Vollenweider,Henry Völzke,Gérard Waeber,Melanie Waldenberger,Henri Wallaschofski,Qin Wang,Gonneke Willemsen,Robert Winqvist,Bruce H. R. Wolffenbuttel,Margaret J. Wright,Dorret I. Boomsma,Michael J. Econs,Kay-Tee Khaw,Ruth J. F. Loos,Ruth J. F. Loos,Mark I. McCarthy,Grant W. Montgomery,John P. Rice,Elizabeth A. Streeten,Elizabeth A. Streeten,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Behrooz Z. Alizadeh,Sven Bergmann,Sven Bergmann,Eric Boerwinkle,Heather A. Boyd,Laura Crisponi,Paolo Gasparini,Christian Gieger,Tamara B. Harris,Erik Ingelsson,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Peter Kraft,Debbie A Lawlor,Andres Metspalu,Craig E. Pennell,Paul M. Ridker,Harold Snieder,Thorkild I. A. Sørensen,Tim D. Spector,David P. Strachan,André G. Uitterlinden,Nicholas J. Wareham,Elisabeth Widen,Marek Zygmunt,Anna Murray,Douglas F. Easton,Kari Stefansson,Kari Stefansson,Joanne M. Murabito,Ken K. Ong +220 more
TL;DR: In this article, the authors used genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies and found robust evidence for 123 signals at 106 genomic loci associated with age at menarche.
Journal ArticleDOI
Common variants in the GDF5-UQCC region are associated with variation in human height
Serena Sanna,Anne U. Jackson,Ramaiah Nagaraja,Cristen J. Willer,Wei-Min Chen,Wei-Min Chen,Lori L. Bonnycastle,Haiqing Shen,Nicholas J. Timpson,Guillaume Lettre,Gianluca Usala,Peter S. Chines,Heather M. Stringham,Laura J. Scott,Mariano Dei,Sandra Lai,Giuseppe Albai,Laura Crisponi,Silvia Naitza,Kimberly F. Doheny,Elizabeth W. Pugh,Yoav Ben-Shlomo,Shah Ebrahim,Debbie A Lawlor,Richard N. Bergman,Richard M. Watanabe,Manuela Uda,Jaakko Tuomilehto,Jaakko Tuomilehto,Josef Coresh,Joel N. Hirschhorn,Alan R. Shuldiner,Alan R. Shuldiner,David Schlessinger,Francis S. Collins,George Davey Smith,Eric Boerwinkle,Antonio Cao,Michael Boehnke,Gonçalo R. Abecasis,Karen L. Mohlke +40 more
TL;DR: It is shown that common variants in the osteoarthritis-associated locus GDF5-UQCC contribute to variation in height with an estimated additive effect of 0.44 cm (overall P < 10−15).