S
Shengxu Li
Researcher at University of Mississippi Medical Center
Publications - 9
Citations - 2139
Shengxu Li is an academic researcher from University of Mississippi Medical Center. The author has contributed to research in topics: Population & Body mass index. The author has an hindex of 8, co-authored 9 publications receiving 1958 citations. Previous affiliations of Shengxu Li include University of Cambridge & Medical Research Council.
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Journal ArticleDOI
Genome-wide association analysis identifies 20 loci that influence adult height
Michael N. Weedon,Hana Lango,Cecilia M. Lindgren,Cecilia M. Lindgren,Chris Wallace,David M. Evans,Massimo Mangino,Rachel M. Freathy,Perry Jrb.,Suzanne Stevens,Alistair S. Hall,Nilesh J. Samani,Beverley M. Shields,Inga Prokopenko,Inga Prokopenko,Martin Farrall,Anna F. Dominiczak,Toby Johnson,Toby Johnson,Toby Johnson,Sven Bergmann,Sven Bergmann,Jacques S. Beckmann,Jacques S. Beckmann,Peter Vollenweider,Dawn M. Waterworth,Vincent Mooser,Palmer Cna.,Palmer Cna.,Andrew D. Morris,Willem H. Ouwehand,Willem H. Ouwehand,Jing Hua Zhao,Shengxu Li,Loos Rjf.,Loos Rjf.,Inês Barroso,Panagiotis Deloukas,Manjinder S. Sandhu,Manjinder S. Sandhu,Eleanor Wheeler,Nicole Soranzo,Michael Inouye,Nicholas J. Wareham,Mark J. Caulfield,Patricia B. Munroe,Andrew T. Hattersley,Mark I. McCarthy,Mark I. McCarthy,Timothy M. Frayling +49 more
TL;DR: The loci the authors identified implicate genes in Hedgehog signaling, extracellular matrix, and cancer pathways, and provide new insights into human growth and developmental processes and insights into the genetic architecture of a classic quantitative trait.
Journal ArticleDOI
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Cathy E. Elks,John R. B. Perry,Patrick Sulem,Daniel I. Chasman,Nora Franceschini,Chunyan He,Kathryn L. Lunetta,Kathryn L. Lunetta,Jenny A. Visser,Enda M. Byrne,Enda M. Byrne,Diana L. Cousminer,Daniel F. Gudbjartsson,Tõnu Esko,Bjarke Feenstra,Jouke-Jan Hottenga,Daniel L. Koller,Zoltán Kutalik,Zoltán Kutalik,Peng Lin,Massimo Mangino,Mara Marongiu,Patrick F. McArdle,Albert V. Smith,Lisette Stolk,Sophie H. Van Wingerden,Jing Hua Zhao,Eva Albrecht,Tanguy Corre,Erik Ingelsson,Caroline Hayward,Patrik K. E. Magnusson,Erin N. Smith,Erin N. Smith,S. Ulivi,Nicole M. Warrington,Lina Zgaga,Helen Alavere,Najaf Amin,Thor Aspelund,Stefania Bandinelli,Inês Barroso,Gerald S. Berenson,Sven Bergmann,Sven Bergmann,Hannah Blackburn,Eric Boerwinkle,Julie E. Buring,Fabio Busonero,Harry Campbell,Stephen J. Chanock,Wei Chen,Marilyn C. Cornelis,David Couper,Andrea D. Coviello,Pio D'Adamo,Ulf de Faire,Eco J. C. de Geus,Panos Deloukas,Angela Döring,George Davey Smith,Douglas F. Easton,Gudny Eiriksdottir,Valur Emilsson,Johan G. Eriksson,Johan G. Eriksson,Luigi Ferrucci,Aaron R. Folsom,Tatiana Foroud,Melissa E. Garcia,Paolo Gasparini,Frank Geller,Christian Gieger,Vilmundur Gudnason,Per Hall,Susan E. Hankinson,Liana Ferreli,Andrew C. Heath,Dena G. Hernandez,Albert Hofman,Frank B. Hu,Thomas Illig,Marjo-Riitta Järvelin,Andrew D. Johnson,David Karasik,Kay-Tee Khaw,Douglas P. Kiel,Tuomas O. Kilpelänen,Ivana Kolcic,Peter Kraft,Lenore J. Launer,Joop S.E. Laven,Shengxu Li,Jianjun Liu,Daniel Levy,Daniel Levy,Nicholas G. Martin,Wendy L. McArdle,Mads Melbye,Vincent Mooser,Jeffrey C. Murray,Sarah S. Murray,Sarah S. Murray,Mike A. Nalls,Pau Navarro,Mari Nelis,Andy R Ness,Kate Northstone,Ben A. Oostra,Munro Peacock,Lyle J. Palmer,Aarno Palotie,Aarno Palotie,Aarno Palotie,Guillaume Paré,Guillaume Paré,Alex Parker,Nancy L. Pedersen,Leena Peltonen,Craig E. Pennell,Paul D.P. Pharoah,Ozren Polasek,Andrew S. Plump,Anneli Pouta,Eleonora Porcu,Thorunn Rafnar,John P. Rice,Susan M. Ring,Fernando Rivadeneira,Igor Rudan,Igor Rudan,Cinzia Sala,Veikko Salomaa,Serena Sanna,David Schlessinger,Nicholas J. Schork,Nicholas J. Schork,Angelo Scuteri,Ayellet V. Segrè,Ayellet V. Segrè,Alan R. Shuldiner,Alan R. Shuldiner,Nicole Soranzo,Nicole Soranzo,Ulla Sovio,Sathanur R. Srinivasan,David P. Strachan,Mar Liis Tammesoo,Emmi Tikkanen,Emmi Tikkanen,Daniela Toniolo,Kim Tsui,Laufey Tryggvadottir,Tyrer Jp,Manuela Uda,Rob M. van Dam,Rob M. van Dam,Joyce B. J. van Meurs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,Michael N. Weedon,H.-Erich Wichmann,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Lauren Young,Guangju Zhai,Wei Vivian Zhuang,Laura J. Bierut,Dorret I. Boomsma,Heather A. Boyd,Laura Crisponi,Ellen W. Demerath,Cornelia M. van Duijn,Michael J. Econs,Tamara B. Harris,David J. Hunter,David J. Hunter,Ruth J. F. Loos,Andres Metspalu,Grant W. Montgomery,Paul M. Ridker,Tim D. Spector,Elizabeth A. Streeten,Kari Stefansson,Kari Stefansson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,André G. Uitterlinden,Elisabeth Widen,Joanne M. Murabito,Joanne M. Murabito,Ken K. Ong,Ken K. Ong,Anna Murray +196 more
TL;DR: A meta-analysis of 32 genome-wide association studies in 87,802 women of European descent found 30 new menarche loci and found suggestive evidence for a further 10 loci, including four previously associated with body mass index and three in or near genes implicated in hormonal regulation.
Journal ArticleDOI
Genetic variation in LIN28B is associated with the timing of puberty
Ken K. Ong,Ken K. Ong,Cathy E. Elks,Cathy E. Elks,Shengxu Li,Shengxu Li,Jing Hua Zhao,Jing Hua Zhao,Jian'an Luan,Jian'an Luan,Lars Bo Andersen,Sheila Bingham,Soren Brage,Soren Brage,George Davey Smith,Ulf Ekelund,Ulf Ekelund,Ulf Ekelund,Christopher J. Gillson,Christopher J. Gillson,Beate Glaser,Jean Golding,Rebecca Hardy,Kay-Tee Khaw,Diana Kuh,Robert Luben,Michele Marcus,Michele Marcus,Michael A. McGeehin,Andy R Ness,Kate Northstone,Susan M. Ring,Carol Rubin,Matthew A. Sims,Matthew A. Sims,Kijoung Song,David P. Strachan,Peter Vollenweider,Gérard Waeber,Dawn M. Waterworth,Andrew Wong,Panagiotis Deloukas,Inês Barroso,Vincent Mooser,Ruth J. F. Loos,Ruth J. F. Loos,Nicholas J. Wareham,Nicholas J. Wareham +47 more
TL;DR: Variation in LIN28B, a potent and specific regulator of microRNA processing, is identified as the first genetic determinant regulating the timing of human pubertal growth and development.
Journal ArticleDOI
Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
Shengxu Li,Jing Hua Zhao,Jian'an Luan,Robert Luben,Sheila A. Rodwell,Kay-Tee Khaw,Ken K. Ong,Nicholas J. Wareham,Ruth J. F. Loos +8 more
TL;DR: Common variants for BMI have small effects on obesity measures and show different association patterns with anthropometric traits, with the largest effect shown for the FTO locus.
Journal ArticleDOI
Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?
Iris M. Heid,Cornelia Huth,Ruth J. F. Loos,Florian Kronenberg,Vera Adamkova,Sonia S. Anand,Kristin G. Ardlie,Heike Biebermann,Peter Bjerregaard,Heiner Boeing,Claude Bouchard,Marina Ciullo,Jackie A. Cooper,Dolores Corella,Dolores Corella,Christian Dina,Christian Dina,James C. Engert,Eva Fisher,Francesc Francés,Francesc Francés,Philippe Froguel,Johannes Hebebrand,Robert A. Hegele,Anke Hinney,Margret R. Hoehe,Frank B. Hu,Jaroslav A. Hubacek,Steve E. Humphries,Steven C. Hunt,Thomas Illig,M. R. Järvelin,M. R. Järvelin,M. R. Järvelin,Marika Kaakinen,Barbara Kollerits,Heiko Krude,Jitender Kumar,Leslie A. Lange,Birgit Langer,Shengxu Li,Andreas Luchner,Helen N. Lyon,Helen N. Lyon,David Meyre,Karen L. Mohlke,Vincent Mooser,Almut Nebel,Thuy Trang Nguyen,Bernhard Paulweber,Louis Pérusse,Lu Qi,Lu Qi,Tuomo Rankinen,Dieter Rosskopf,Stefan Schreiber,Shantanu Sengupta,Rossella Sorice,Anita Suk,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Henry Völzke,Karani Santhanakrishnan Vimaleswaran,Nicholas J. Wareham,Dawn M. Waterworth,Salim Yusuf,Cecilia M. Lindgren,Cecilia M. Lindgren,Mark I. McCarthy,Mark I. McCarthy,Christoph Lange,Joel N. Hirschhorn,Joel N. Hirschhorn,Nan M. Laird,H-Erich Wichmann +75 more
TL;DR: The data suggested an association with extreme degrees of obesity, and consequently heterogeneous effects from different study designs may mask an underlying association when unaccounted for.