V
Volker Hovestadt
Researcher at Harvard University
Publications - 122
Citations - 23957
Volker Hovestadt is an academic researcher from Harvard University. The author has contributed to research in topics: DNA methylation & Biology. The author has an hindex of 54, co-authored 103 publications receiving 17611 citations. Previous affiliations of Volker Hovestadt include University of Bonn & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Extended-representation bisulfite sequencing of gene regulatory elements in multiplexed samples and single cells.
Sarah J. Shareef,Sarah J. Shareef,Samantha M. Bevill,Samantha M. Bevill,Ayush T. Raman,Ayush T. Raman,Martin J. Aryee,Martin J. Aryee,Peter van Galen,Peter van Galen,Peter van Galen,Volker Hovestadt,Bradley E. Bernstein,Bradley E. Bernstein +13 more
TL;DR: In this article, an extended representation bisulfite sequencing (XRBS) method was proposed for targeted profiling of DNA methylation, which can expand coverage of regulatory elements and enrich informative CpG dinucleotides in promoters, enhancers and CTCF binding sites.
Journal ArticleDOI
Corrigendum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Jeremy Schwartzentruber,Andrey Korshunov,Xiaoyang Liu,David T.W. Jones,Elke Pfaff,Karine Jacob,Dominik Sturm,Adam M. Fontebasso,Dong Anh Khuong Quang,Martje Tönjes,Volker Hovestadt,Steffen Albrecht,Marcel Kool,André Nantel,Carolin Konermann,Anders Lindroth,Natalie Jäger,Tobias Rausch,Marina Ryzhova,Jan O. Korbel,Thomas Hielscher,Peter Hauser,Miklós Garami,Almos Klekner,László Bognár,Martin Ebinger,Martin U. Schuhmann,Wolfram Scheurlen,Arnulf Pekrun,Michael C. Frühwald,Wolfgang Roggendorf,CM Kramm,Matthias Dürken,Jeffrey Atkinson,Pierre Lepage,Alexandre Montpetit,Magdalena Zakrzewska,Krzystof Zakrzewski,Pawel P. Liberski,Zhifeng Dong,Peter M. Siegel,Andreas E. Kulozik,Marc Zapatka,Abhijit Guha,David Malkin,Jörg Felsberg,Guido Reifenberger,Andreas von Deimling,Koichi Ichimura,V. Peter Collins,Hendrik Witt,Till Milde,Olaf Witt,Cindy Zhang,Pedro Castelo-Branco,Peter Lichter,Damien Faury,Uri Tabori,Christoph Plass,Jacek Majewski,Stefan M. Pfister,Nada Jabado +61 more
TL;DR: This corrects the article to say that the author of the paper was a post-graduate student at the University of California, Berkeley, when the study was in fact a PhD student.
Journal ArticleDOI
High grade gliomas
Alexis Leonard,Johannes Wolff,Rajarshi Sengupta,Jayne Marassa,David Piwnica-Worms,Joshua B. Rubin,Ian F. Pollack,Regina I. Jakacki,Lisa H. Butterfield,Hideho Okada,Jason Fangusaro,Katherine E. Warren,Christina Mullins,Piek Jürgen,Schubert Julia,Classen Carl Friedrich,Stephen T. Keir,Julia R. Saling,Martin A. Roskoski,Henry S. Friedman,Darell D. Bigner,Christopher L. Moertel,Michael R. Olin,Tambra Dahlheimer,Michael P. Gustafson,Darin Sumstad,David H. McKenna,Walter C. Low,David Nascene,A. Dietz,John R. Ohlfest,Dominik Sturm,Hendrik Witt,Volker Hovestadt,Dong Anh Khuong Quan,David T.W. Jones,Carolin Konermann,Elke Pfaff,Andrey Korshunov,Marina Rizhova,Till Milde,Olaf Witt,Marc Zapatka,V. Peter Collins,Marcel Kool,Guido Reifenberger,Peter Lichter,Anders Lindroth,Christoph Plass,Nada Jabado,Stefan M. Pfister,Barry Pizer,Alireza Salehzadeh,Andrew Brodbelt,Conor Mallucci,María Sol Brassesco,Julia Pezuk,Andressa Morales,Jaqueline de Oliveira,Gabriela Molinari Roberto,Kazuo Umezawa,Elvis Valera,Eduardo Magalhães Rego,Carlos Alberto Scrideli,Luiz Gonzaga Tone,Susanna J.E. Veringa,Dannis G. van Vuurden,Pieter Wesseling,W. Peter Vandertop,David P. Noske,Thomas Wurdinger,Gertjan J.L. Kaspers,Esther Hulleman,Karen Wright,Alberto Broniscer,Anne Bendel,Daniel C. Bowers,John Robertson Crawford,Paul G. Fisher,Tim Hassall,Gregory T. Armstrong,Justin N. Baker,Ibrahim Qaddoumi,Giles W. Robinson,Cynthia Wetmore,Paul Klimo,Frederick A. Boop,Arzu Onar-Thomas,David W. Ellison,Amar Gajjar,Ofelia Cruz,Carmen de Torres,Mariona Suñol,Eva Peguero Rodríguez,Laura Alonso,Andreu Parareda,Teresa Cardesa,Hector Salvador,Veronica Celis,A. Guillen,Gemma Garcia,Jordi Muchart,Carlos Trampal,Maria Luisa Martin,Monica Rebollo,Jaume Mora,Anna F. Piotrowski,Agnes Kowalska,Patricia Coyle,Stuart Smith,Hazel A. Rogers,Donald Macarthur,Richard Grundy,Diane Puccetti,Shahriar Salamat,Tabassum A. Kennedy,Neha Patel,Kristin A. Bradley,Kristin Casey,Bermans J. Iskandar,Yoshiko Nakano,Keiko Okada,Yuko Osugi,Kai Yamasaki,Hiroyuki Fujisaki,Hiroko Fukushima,Takeshi Inoue,Yasuhiro Matsusaka,Hiroaki Sakamoto,Junichi Hara,Steven De Vleeschouwer,Hilko Ardon,Frank Van Calenbergh,Raf Sciot,Guido Wilms,Johan van Loon,Jan Goffin,Stefaan Van Gool,David Rusinak,Peter Knight,Kenan Onel,David S. Wargowski,Amy Stettner,Ayat B. Al-Ghafari,Wiyada Punjaruk,Beth Coyle,Ian D. Kerr,Enric Xipell,María Rodriguez,Marisol Gonzalez-Huarriz,María Teresa Tuñon,Idoya Zazpe,Sonia Tejada-Solís,Ricardo Díez-Valle,Juan Fueyo,Candelaria Gomez-Manzano,Marta M. Alonso,Devang Pastakia,Cynthia McCully,Robert L. Murphy,John Bacher,Marvin L. Thomas,Emilie A. Steffen-Smith,Kadharbatcha S. Saleem,Stuart Waldbridge,Brigitte C. Widemann,Katherine Warren,Evelina Miele,Francesca R. Buttarelli,Antonella Arcella,Federica Begalli,Agnese Po,Caterina Baldi,G. Carissimo,Manila Antonelli,V. Donofrio,I. Morra,Paolo Nozza,Alberto Gulino,Felice Giangaspero,Elisabetta Ferretti,Iris Elens,Femke Pauwels,Sara Fritzell,Sofia Eberstål,Emma Sandén,Edward Visse,Anna Darabi,Peter Siesjö,Patrick J. McDonald,Jens Wrogemann,Sherry Krawitz,Marc R. Del Bigio,David D. Eisenstat,Robert Kwiecien,Torsten Pietsch,Andreas Faldum,RD Kortmann,M. Warmuth-Metz,Stefan Rutkowski,Irene Slavc,Christof M. Kramm,Urmila Uparkar,Russell Geyer,Ralph P. Ermoian,Richard G. Ellenbogen,Sarah Leary,Joanna Triscott,Kaiji Hu,Abbas Fotovati,Stephen Yip,Richard E. Kast,Brian Toyota,Sandra E. Dunn,Meenakshi Hegde,Amanda Corder,Kevin Chow,Malini Mukherjee,Aidin Ashoori,Vita Brawley,Helen E. Heslop,Stephen Gottschalk,Eric Yvon,Nabil Ahmed,Tai-Tong Wong,Feng-Yi Yang,Maggie Lu,Hsiang-Fa Liang,Hsin-Ell Wang,Ren-Shyan Liu,Ming-Che Teng,Chuek-Chuan Yen,Sameer Agnihotri,Christian Ternamian,Chris Jones,Gelareh Zadeh,James T. Rutka,Cynthia Hawkins,Iwona Filipek,Monika Drogosiewicz,Marta Perek-Polnik,Ewa Swieszkowska,Bozenna Dembowska Baginska,Elzbieta Jurkiewicz,Danuta Perek,Alexander Kuehn,Fabian Falkenstein,Astrid Gnekow,Christof Kramm,Michael D. Brooks,Erin Jackson,Robi D. Mitra,Joshua B. Rubin,Xiao-Yang Liu,Jeremy Schwartzentruber,Adam M. Fontebasso,Dong-Anh Khuong Quang,Steffen Albrecht,Zhifeng Dong,Peter M. Siegel,Andreas Von Diemling,Damien Faury,Uri Tabori,Jacek Majewski,Rishi Lulla,María E. Echevarría,Tord D. Alden,Arthur J DiPatri,Tadanori Tomita,Stewart Goldman,Tong Lin,Thomas E. Merchant,Mehmet Kocak,Atmaram S. Pai Panandiker,Gregory T. Armstrong,Gerrit H. Gielen,Anja zur Muehlen,CM Kramm,Christopher Hubert,Yu Ding,Chad Toledo,Patrick J. Paddison,James M. Olson,Meera Nandhabalan,Lynn Bjerke,Dorine A. Bax,Diana Carvalho,I. Bajrami,Alan Ashworth,Christopher J. Lord,Darren Hargrave,Rui Manuel Reis,Paul Workman,Suzie Little,Sergey Popov,Alexa Jury,Anna Burford,Lawrence Doey,Safa Al-Sarraj,Juliane M. Jürgensmeier,Lina Chen,Iwanka Kozarewa,Suzanne J. Baker,Lara Perryman,Gary Box,Florence I. Raynaud,Suzanne A. Eccles,Marta Viana-Pereira,Márcia Santos Pereira,Tim Forshew,Ruth G. Tatevossian,Denise Sheer,Jose Pimental,Manuel Pires,Chitra Sarkar,Prerana Jha,Irene Rose Pia Patrick,Kumar Somasundaram,Pankaj Pathak,Mehar Chand Sharma,Vaishali Suri,Ashish Suri,Noha Gerges,Takrima Haque,Andre Nantel,Cathy Lee,James Chen,Chitra Venugopal,Ash Singhal,Chris Dunham,John H. Kerr,Maite Verreault,Hiro Wakimoto,Aarthi Jayanthan,Aru Narendran,Sheila K. Singh,Géraldine Giraud,Stefan Holm,Bengt Gustavsson,Roman Kizyma,Zoryana Kizyma,Lesya Dvornyak,Bogdan Kotsay,Sridhar Epari,Praveen Sharma,Mamta Gurav,Tejpal Gupta,Prakash Shetty,Aliasgar Moiyadi,Shubhada Kane,Rakesh Jalali +350 more
TL;DR: Methylation of the promoter for the MGMT gene predicts for increased sensitivity to DNA alkylat ing agents such as temozolomide and is prognostic for overall survival (OS) in patients with GBM, especially older patients.
Journal ArticleDOI
Methylation profiling of paediatric pilocytic astrocytoma reveals variants specifically associated with tumour location and predictive of recurrence
Alexandra Sexton-Oates,Alexandra Sexton-Oates,Andrew Dodgshun,Andrew Dodgshun,Volker Hovestadt,David T.W. Jones,David M. Ashley,Michael J. Sullivan,Michael J. Sullivan,Duncan MacGregor,Duncan MacGregor,Richard Saffery,Richard Saffery +12 more
TL;DR: The findings show location‐specific epigenetic profiles for PAs, potentially reflecting their cell type of origin, which may account for differences in clinical behaviour according to location independent of histopathology.
Proceedings ArticleDOI
Abstract 3687: An integrative genomics approach identifies distinct molecular and epigenetic subgroups of pediatric glioblastoma
Dominik Sturm,Hendrik Witt,Karine Jacob,Carolin Konermann,David T.W. Jones,Elke Pfaff,Andrey Korshunov,Marina Rizhova,Volker Hovestadt,Marc Remke,Timothy E. Van Meter,Michael C. Frühwald,CM Kramm,Andreas E. Kulozik,Andreas von Deimling,Christian Hartmann,Till Milde,Olaf Witt,Guido Reifenberger,Peter Lichter,Christoph Plass,Nada Jabado,Stefan M. Pfister +22 more
TL;DR: This study, one of the largest cohorts of pediatric GBM investigated for molecular alterations to date, describes frequent genetic and epigenetic features of this devastating disease and further emphasizes and differences between adult and pediatric G BM.