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Showing papers by "Academia Sinica published in 2017"


Journal ArticleDOI
31 Mar 2017-Science
TL;DR: The negative effects of climate change cannot be adequately anticipated or prepared for unless species responses are explicitly included in decision-making and global strategic frameworks, and feedbacks on climate itself are documented.
Abstract: Distributions of Earth’s species are changing at accelerating rates, increasingly driven by human-mediated climate change. Such changes are already altering the composition of ecological communities, but beyond conservation of natural systems, how and why does this matter? We review evidence that climate-driven species redistribution at regional to global scales affects ecosystem functioning, human well-being, and the dynamics of climate change itself. Production of natural resources required for food security, patterns of disease transmission, and processes of carbon sequestration are all altered by changes in species distribution. Consideration of these effects of biodiversity redistribution is critical yet lacking in most mitigation and adaptation strategies, including the United Nation’s Sustainable Development Goals.

1,917 citations


Journal ArticleDOI
Bin Zhou1, James Bentham1, Mariachiara Di Cesare2, Honor Bixby1  +787 moreInstitutions (231)
TL;DR: The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries, and the contributions of changes in prevalence versus population growth and ageing to the increase.

1,573 citations


Journal ArticleDOI
TL;DR: A synthetic strategy to grow Janus monolayers of transition metal dichalcogenides breaking the out-of-plane structural symmetry of MoSSe by means of scanning transmission electron microscopy and energy-dependent X-ray photoelectron spectroscopy is reported.
Abstract: Structural symmetry-breaking plays a crucial role in determining the electronic band structures of two-dimensional materials. Tremendous efforts have been devoted to breaking the in-plane symmetry of graphene with electric fields on AB-stacked bilayers or stacked van der Waals heterostructures. In contrast, transition metal dichalcogenide monolayers are semiconductors with intrinsic in-plane asymmetry, leading to direct electronic bandgaps, distinctive optical properties and great potential in optoelectronics. Apart from their in-plane inversion asymmetry, an additional degree of freedom allowing spin manipulation can be induced by breaking the out-of-plane mirror symmetry with external electric fields or, as theoretically proposed, with an asymmetric out-of-plane structural configuration. Here, we report a synthetic strategy to grow Janus monolayers of transition metal dichalcogenides breaking the out-of-plane structural symmetry. In particular, based on a MoS2 monolayer, we fully replace the top-layer S with Se atoms. We confirm the Janus structure of MoSSe directly by means of scanning transmission electron microscopy and energy-dependent X-ray photoelectron spectroscopy, and prove the existence of vertical dipoles by second harmonic generation and piezoresponse force microscopy measurements.

1,302 citations


Journal ArticleDOI
02 Nov 2017-Nature
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
Abstract: Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10-8. The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention.

1,014 citations


Journal ArticleDOI
TL;DR: A design principle is proposed to realize achromatic metasurface devices which successfully eliminate the chromatic aberration over a continuous wavelength region from 1200 to 1680 nm for circularly-polarized incidences in a reflection scheme.
Abstract: Among various flat optical devices, metasurfaces have presented their great ability in efficient manipulation of light fields and have been proposed for variety of devices with specific functionalities. However, due to the high phase dispersion of their building blocks, metasurfaces significantly suffer from large chromatic aberration. Here we propose a design principle to realize achromatic metasurface devices which successfully eliminate the chromatic aberration over a continuous wavelength region from 1200 to 1680 nm for circularly-polarized incidences in a reflection scheme. For this proof-of-concept, we demonstrate broadband achromatic metalenses (with the efficiency on the order of ∼12%) which are capable of focusing light with arbitrary wavelength at the same focal plane. A broadband achromatic gradient metasurface is also implemented, which is able to deflect wide-band light by the same angle. Through this approach, various flat achromatic devices that were previously impossible can be realized, which will allow innovation in full-color detection and imaging. Metasurfaces suffer from large chromatic aberration due to the high phase dispersion of their building blocks, limiting their applications. Here, Wang et al. design achromatic metasurface devices which eliminate the chromatic aberration over a continuous region from 1200 to 1680 nm in a reflection schleme.

679 citations


Journal ArticleDOI
01 Apr 2017
TL;DR: Metasurfaces have become a rapidly growing field of research in recent years due to their exceptional abilities in light manipulation and versatility in ultrathin optical applications and are promising for integration with on-chip nanophotonic devices owing to their planar profiles.
Abstract: Metasurfaces have become a rapidly growing field of research in recent years due to their exceptional abilities in light manipulation and versatility in ultrathin optical applications. They also significantly benefit from their simplified fabrication process compared to metamaterials and are promising for integration with on-chip nanophotonic devices owing to their planar profiles. The recent progress in metasurfaces is reviewed and they are classified into six categories according to their underlying physics for realizing full 2π phase manipulation. Starting from multi-resonance and gap-plasmon metasurfaces that rely on the geometric effect of plasmonic nanoantennas, Pancharatnam–Berry-phase metasurfaces, on the other hand, use identical nanoantennas with varying rotation angles. The recent development of Huygens' metasurfaces and all-dielectric metasurfaces especially benefit from highly efficient transmission applications. An overview of state-of-the-art fabrication technologies is introduced, ranging from the commonly used processes such as electron beam and focused-ion-beam lithography to some emerging techniques, such as self-assembly and nanoimprint lithography. A variety of functional materials incorporated to reconfigurable or tunable metasurfaces is also presented. Finally, a few of the current intriguing metasurface-based applications are discussed, and opinions on future prospects are provided.

496 citations


Journal ArticleDOI
TL;DR: In this article, a new measurement of the Hubble Constant H-0 and other cosmological parameters based on the joint analysis of three multiply imaged quasar systems with measured gravitational time delays is presented.
Abstract: We present a new measurement of the Hubble Constant H-0 and other cosmological parameters based on the joint analysis of three multiply imaged quasar systems with measured gravitational time delays. First, we measure the time delay of HE 0435-1223 from 13-yr light curves obtained as part of the COSMOGRAIL project. Companion papers detail the modelling of the main deflectors and line-of-sight effects, and how these data are combined to determine the time-delay distance of HE 0435-1223. Crucially, the measurements are carried out blindly with respect to cosmological parameters in order to avoid confirmation bias. We then combine the time-delay distance of HE 0435-1223 with previous measurements from systems B1608+656 and RXJ1131-1231 to create a Time Delay Strong Lensing probe (IDSL). In flat A cold dark matter (ACDM) with free matter and energy density, we find H-0 = 71.9(-3.0)(+2.4) km s(-1) Mpc(-1) and Omega(Lambda) = 0.62(-0.35)(+0.24) This measurement is completely independent of, and in agreement with, the local distance ladder measurements of H-0. We explore more general cosmological models combining TDSL with other probes, illustrating its power to break degeneracies inherent to other methods. The joint constraints from IDSL and Planck are H-0 = 69.2(-2.2)(+1.4) km s(-1) Mpc(-1), Omega(Lambda) = 0.70(-0.01)(+0.01) and Omega(k) = 0.003(-0.006)(+0.004) in open ACDM and H-0 = 79.0(-4.2)(+4.4) km s(-1) Mpc(-1), Omega(de) = 0.77(-0.03)(+0.02) and w = -1.38(-0.16)(+0.14) in flat wCDM. In combination with Planck and baryon acoustic oscillation data, when relaxing the constraints on the numbers of relativistic species we find N-eff = 3.34(-0.21)(+0.21) in N-eff Lambda CDM and when relaxing the total mass of neutrinos we find Sigma rn(nu) <= 0.182 eV in m(nu) Lambda CDM. Finally, in an open wCDM in combination with Planck and cosmic microwave background lensing, we find H-0 = 77.9(-4.2)(+5.0) km s(-1) Mpc(-1), Omega(de) = 0.77(-0.03)(+0.03), Omega(k) = -0.003(-0.004)(+0.004) and w = -1.37(-0.23)(+0.18).

493 citations


Journal ArticleDOI
Morad Aaboud, Georges Aad1, Brad Abbott2, Jalal Abdallah3  +2845 moreInstitutions (197)
TL;DR: This paper presents a short overview of the changes to the trigger and data acquisition systems during the first long shutdown of the LHC and shows the performance of the trigger system and its components based on the 2015 proton–proton collision data.
Abstract: During 2015 the ATLAS experiment recorded 3.8 fb(-1) of proton-proton collision data at a centre-of-mass energy of 13 TeV. The ATLAS trigger system is a crucial component of the experiment, respons ...

488 citations


Journal ArticleDOI
TL;DR: Two different intercalation processes involving chloroaluminate anions at the two discharging plateaus are shown, while C–Cl bonding on the surface, or edges of natural graphite, is found using X-ray absorption spectroscopy, and theoretical calculations are employed to investigate the intercalated behaviour of choloraluminateAnions in the graphite electrode.
Abstract: Recently, interest in aluminium ion batteries with aluminium anodes, graphite cathodes and ionic liquid electrolytes has increased; however, much remains to be done to increase the cathode capacity and to understand details of the anion–graphite intercalation mechanism. Here, an aluminium ion battery cell made using pristine natural graphite flakes achieves a specific capacity of ∼110 mAh g−1 with Coulombic efficiency ∼98%, at a current density of 99 mA g−1 (0.9 C) with clear discharge voltage plateaus (2.25–2.0 V and 1.9–1.5 V). The cell has a capacity of 60 mAh g−1 at 6 C, over 6,000 cycles with Coulombic efficiency ∼ 99%. Raman spectroscopy shows two different intercalation processes involving chloroaluminate anions at the two discharging plateaus, while C–Cl bonding on the surface, or edges of natural graphite, is found using X-ray absorption spectroscopy. Finally, theoretical calculations are employed to investigate the intercalation behaviour of choloraluminate anions in the graphite electrode. Rechargeable aluminium ion batteries are an emerging class of energy storage device. Here the authors reveal high-quality natural graphite as a promising cathode for Al-ion batteries, also identifying chloroaluminate anion intercalation in graphite by Raman spectroscopy.

456 citations


Journal ArticleDOI
TL;DR: A periodic modulation of the local bandgap in the rotationally aligned MoS2/WSe2 bilayer creates a 2D electronic superlattice and quantitatively determine the influence of interlayer coupling on the electronic structure of the hetero-bilayer at different critical points.
Abstract: By using direct growth, we create a rotationally aligned MoS2/WSe2 hetero-bilayer as a designer van der Waals heterostructure. With rotational alignment, the lattice mismatch leads to a periodic variation of atomic registry between individual van der Waals layers, exhibiting a Moire pattern with a well-defined periodicity. By combining scanning tunneling microscopy/spectroscopy, transmission electron microscopy, and first-principles calculations, we investigate interlayer coupling as a function of atomic registry. We quantitatively determine the influence of interlayer coupling on the electronic structure of the hetero-bilayer at different critical points. We show that the direct gap semiconductor concept is retained in the bilayer although the valence and conduction band edges are located at different layers. We further show that the local bandgap is periodically modulated in the X-Y direction with an amplitude of ~0.15 eV, leading to the formation of a two-dimensional electronic superlattice.

443 citations


Journal ArticleDOI
Georges Aad1, Alexander Kupco2, P. Davison3, Samuel Webb4  +2888 moreInstitutions (192)
TL;DR: Topological cell clustering is established as a well-performing calorimeter signal definition for jet and missing transverse momentum reconstruction in ATLAS and is exploited to apply a local energy calibration and corrections depending on the nature of the cluster.
Abstract: The reconstruction of the signal from hadrons and jets emerging from the proton–proton collisions at the Large Hadron Collider (LHC) and entering the ATLAS calorimeters is based on a three-dimensional topological clustering of individual calorimeter cell signals. The cluster formation follows cell signal-significance patterns generated by electromagnetic and hadronic showers. In this, the clustering algorithm implicitly performs a topological noise suppression by removing cells with insignificant signals which are not in close proximity to cells with significant signals. The resulting topological cell clusters have shape and location information, which is exploited to apply a local energy calibration and corrections depending on the nature of the cluster. Topological cell clustering is established as a well-performing calorimeter signal definition for jet and missing transverse momentum reconstruction in ATLAS.

Journal ArticleDOI
TL;DR: The H0LiCOW (H-0 Lenses in COSMOGRAIL's Wellspring) project as mentioned in this paper is a program that aims to measure H-0 with <3.5 per cent uncertainty from five lens systems (B1608+ 656, RXJ1131-1231, HE 0435-1223, WFI2033-4723 and HE 1104-1805).
Abstract: Strong gravitational lens systems with time delays between the multiple images allow measurements of time-delay distances, which are primarily sensitive to the Hubble constant that is key to probing dark energy, neutrino physics and the spatial curvature of the Universe, as well as discovering new physics. We present H0LiCOW (H-0 Lenses in COSMOGRAIL's Wellspring), a program that aims to measure H-0 with <3.5 per cent uncertainty from five lens systems (B1608+ 656, RXJ1131-1231, HE 0435-1223, WFI2033-4723 and HE 1104-1805). We have been acquiring (1) time delays through COSMOGRAIL and Very Large Array monitoring, (2) high-resolution Hubble Space Telescope imaging for the lens mass modelling, (3) wide-field imaging and spectroscopy to characterize the lens environment and (4) moderate-resolution spectroscopy to obtain the stellar velocity dispersion of the lenses for mass modelling. In cosmological models with one-parameter extension to flat Lambda cold dark matter, we expect to measure H-0 to <3.5 per cent in most models, spatial curvature Omega(k) to 0.004, w to 0.14 and the effective number of neutrino species to 0.2 (1s uncertainties) when combined with current cosmic microwave background (CMB) experiments. These are, respectively, a factor of similar to 15, similar to 2 and similar to 1.5 tighter than CMB alone. Our data set will further enable us to study the stellar initial mass function of the lens galaxies, and the co-evolution of supermassive black holes and their host galaxies. This program will provide a foundation for extracting cosmological distances from the hundreds of time-delay lenses that are expected to be discovered in current and future surveys.

Journal ArticleDOI
Morad Aaboud, Alexander Kupco1, Peter Davison2, Samuel Webb3  +2944 moreInstitutions (220)
TL;DR: In this article, a search for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states was conducted using 36 : 1 fb(-1) of proton-proton collision data.
Abstract: A search is conducted for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states. The search uses 36 : 1 fb(-1) of proton-proton collision data, collected at root ...

Posted Content
TL;DR: In this article, three models for symbolic multi-track music generation under the framework of generative adversarial networks (GANs) are proposed, referred to as the jamming model, the composer model and the hybrid model.
Abstract: Generating music has a few notable differences from generating images and videos. First, music is an art of time, necessitating a temporal model. Second, music is usually composed of multiple instruments/tracks with their own temporal dynamics, but collectively they unfold over time interdependently. Lastly, musical notes are often grouped into chords, arpeggios or melodies in polyphonic music, and thereby introducing a chronological ordering of notes is not naturally suitable. In this paper, we propose three models for symbolic multi-track music generation under the framework of generative adversarial networks (GANs). The three models, which differ in the underlying assumptions and accordingly the network architectures, are referred to as the jamming model, the composer model and the hybrid model. We trained the proposed models on a dataset of over one hundred thousand bars of rock music and applied them to generate piano-rolls of five tracks: bass, drums, guitar, piano and strings. A few intra-track and inter-track objective metrics are also proposed to evaluate the generative results, in addition to a subjective user study. We show that our models can generate coherent music of four bars right from scratch (i.e. without human inputs). We also extend our models to human-AI cooperative music generation: given a specific track composed by human, we can generate four additional tracks to accompany it. All code, the dataset and the rendered audio samples are available at this https URL .

Journal ArticleDOI
TL;DR: The versatility and compactness of the MPG capable of transforming any incident wave into light beams of arbitrary polarizations over a broad spectral range are an important step forward in achieving a complete set of flat optics for integrated photonics with far-reaching applications.
Abstract: All forms of light manipulation rely on light–matter interaction, the primary mechanism of which is the modulation of its electromagnetic fields by the localized electromagnetic fields of atoms. One of the important factors that influence the strength of interaction is the polarization of the electromagnetic field. The generation and manipulation of light polarization have been traditionally accomplished with bulky optical components such as waveplates, polarizers, and polarization beam splitters that are optically thick. The miniaturization of these devices is highly desirable for the development of a new class of compact, flat, and broadband optical components that can be integrated together on a single photonics chip. Here we demonstrate, for the first time, a reflective metasurface polarization generator (MPG) capable of producing light beams of any polarizations all from a linearly polarized light source with a single optically thin chip. Six polarization light beams are achieved simultaneously inclu...

Journal ArticleDOI
Eleanor Wheeler1, Aaron Leong2, Ching-Ti Liu3, Marie-France Hivert2  +255 moreInstitutions (89)
TL;DR: This multiancestry study recommends investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G 6PD deficiency is common, and investigates the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance.
Abstract: Background: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identif ...

Journal ArticleDOI
TL;DR: Progress made over the past two to three decades toward delineating the structures and functions of the catalytic sites in two MMOs are reviewed, culminating in the first successful biomimetic catalyst capable of efficient methane oxidation without overoxidation at room temperature.
Abstract: Methane monooxygenases (MMOs) mediate the facile conversion of methane into methanol in methanotrophic bacteria with high efficiency under ambient conditions. Because the selective oxidation of methane is extremely challenging, there is considerable interest in understanding how these enzymes carry out this difficult chemistry. The impetus of these efforts is to learn from the microbes to develop a biomimetic catalyst to accomplish the same chemical transformation. Here, we review the progress made over the past two to three decades toward delineating the structures and functions of the catalytic sites in two MMOs: soluble methane monooxygenase (sMMO) and particulate methane monooxygenase (pMMO). sMMO is a water-soluble three-component protein complex consisting of a hydroxylase with a nonheme diiron catalytic site; pMMO is a membrane-bound metalloenzyme with a unique tricopper cluster as the site of hydroxylation. The metal cluster in each of these MMOs harnesses O2 to functionalize the C—H bond using di...

Journal ArticleDOI
TL;DR: The approach with low-cost, semiconductor fabrication compatibility and high working efficiency characteristics offers a way for establishing a complete set of flat optical components for a wide range of applications such as compact imaging sensors, optical spectroscopy, and high-resolution lithography, just named a few.
Abstract: Metasurface-based components are known to be one of the promising candidates for developing flat optical systems. However, their low working efficiency highly limits the use of such flat components for feasible applications. Although the introduction of the metallic mirror has been demonstrated to successfully enhance the efficiency, it is still somehow limited for imaging and sensing applications because they are only available for devices operating in a reflection fashion. Here, we demonstrate three individual GaN-based metalenses working in a transmission window with extremely high operation efficiency at visible light (87%, 91.6%, and 50.6% for blue, green, and red light, respectively). For the proof of concept, a multiplex color router with dielectric metalens, which is capable of guiding individual primary colors into different spatial positions, is experimentally verified based on the design of out-of-plane focusing metalens. Our approach with low-cost, semiconductor fabrication compatibility and h...

Journal ArticleDOI
TL;DR: In this paper, the in situ growth of metal Cu2Se on the surface of CNTs was realized and a series of hybrid materials were fabricated using the special interaction between metal Cu and multi-walled carbon nanotubes.
Abstract: Here, by utilizing the special interaction between metal Cu and multi-walled carbon nanotubes (CNTs), we have successfully realized the in situ growth of Cu2Se on the surface of CNTs and then fabricated a series of Cu2Se/CNT hybrid materials. Due to the high degree of homogeneously dispersed molecular CNTs inside the Cu2Se matrix, a record-high thermoelectric figure of merit zT of 2.4 at 1000 K has been achieved.

Journal ArticleDOI
TL;DR: A genome-wide association study (GWAS) of predominantly estrogen receptor (ER)-positive disease and BRCA1 mutation carrier GWAS observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies, which explain approximately 16% of the familial risk of this breast cancer subtype.
Abstract: Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease. We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. We identified independent associations at P < 5 × 10-8 with ten variants at nine new loci. At P < 0.05, we replicated associations with 10 of 11 variants previously reported in ER-negative disease or BRCA1 mutation carrier GWAS and observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies. These 125 variants explain approximately 16% of the familial risk of this breast cancer subtype. There was high genetic correlation (0.72) between risk of ER-negative breast cancer and breast cancer risk for BRCA1 mutation carriers. These findings may lead to improved risk prediction and inform further fine-mapping and functional work to better understand the biological basis of ER-negative breast cancer.

Proceedings ArticleDOI
20 Aug 2017
TL;DR: In this article, a variational autoencoding Wasserstein generative adversarial network (VAW-GAN) is proposed for voice conversion from unaligned speech corpora.
Abstract: Building a voice conversion (VC) system from non-parallel speech corpora is challenging but highly valuable in real application scenarios. In most situations, the source and the target speakers do not repeat the same texts or they may even speak different languages. In this case, one possible, although indirect, solution is to build a generative model for speech. Generative models focus on explaining the observations with latent variables instead of learning a pairwise transformation function, thereby bypassing the requirement of speech frame alignment. In this paper, we propose a non-parallel VC framework with a variational autoencoding Wasserstein generative adversarial network (VAW-GAN) that explicitly considers a VC objective when building the speech model. Experimental results corroborate the capability of our framework for building a VC system from unaligned data, and demonstrate improved conversion quality.

Journal ArticleDOI
TL;DR: The authors report crystal structures of a PET-hydrolyzing enzyme from the microbe Ideonella sakaiensis bound to substrate and product analogs, and suggest a catalytic mechanism for its PET-degrading activity.
Abstract: PET hydrolase (PETase), which hydrolyzes polyethylene terephthalate (PET) into soluble building blocks, provides an attractive avenue for the bioconversion of plastics. Here we present the structures of a novel PETase from the PET-consuming microbe Ideonella sakaiensis in complex with substrate and product analogs. Through structural analyses, mutagenesis, and activity measurements, a substrate-binding mode is proposed, and several features critical for catalysis are elucidated.

Journal ArticleDOI
Morad Aaboud, Georges Aad1, Brad Abbott2, Jalal Abdallah3  +2906 moreInstitutions (214)
TL;DR: In this paper, Dijet events are studied in the proton-proton collision dataset recorded at root s = 13 TeV with the ATLAS detector at the Large Hadron Collider in 2015 and 2016.
Abstract: Dijet events are studied in the proton-proton collision dataset recorded at root s = 13 TeV with the ATLAS detector at the Large Hadron Collider in 2015 and 2016, corresponding to integrated lumino ...

Journal ArticleDOI
13 Sep 2017-Nature
TL;DR: New light is shed on the genetic mechanisms underpinning key orchid innovations, including the development of the labellum and gynostemium, pollinia, and seeds without endosperm, as well as the evolution of epiphytism; reveals relationships between the Orchidaceae subfamilies; and helps clarify the evolutionary history of orchids within the angiosperms.
Abstract: Constituting approximately 10% of flowering plant species, orchids (Orchidaceae) display unique flower morphologies, possess an extraordinary diversity in lifestyle, and have successfully colonized almost every habitat on Earth. Here we report the draft genome sequence of Apostasia shenzhenica, a representative of one of two genera that form a sister lineage to the rest of the Orchidaceae, providing a reference for inferring the genome content and structure of the most recent common ancestor of all extant orchids and improving our understanding of their origins and evolution. In addition, we present transcriptome data for representatives of Vanilloideae, Cypripedioideae and Orchidoideae, and novel third-generation genome data for two species of Epidendroideae, covering all five orchid subfamilies. A. shenzhenica shows clear evidence of a whole-genome duplication, which is shared by all orchids and occurred shortly before their divergence. Comparisons between A. shenzhenica and other orchids and angiosperms also permitted the reconstruction of an ancestral orchid gene toolkit. We identify new gene families, gene family expansions and contractions, and changes within MADS-box gene classes, which control a diverse suite of developmental processes, during orchid evolution. This study sheds new light on the genetic mechanisms underpinning key orchid innovations, including the development of the labellum and gynostemium, pollinia, and seeds without endosperm, as well as the evolution of epiphytism; reveals relationships between the Orchidaceae subfamilies; and helps clarify the evolutionary history of orchids within the angiosperms.

Journal ArticleDOI
M. Aguilar, O. Demakov1, Ying Lu2, U. Becker1  +253 moreInstitutions (27)
TL;DR: The observation of new properties of primary cosmic rays He, C, and O measured in the rigidity (momentum/charge) range 2 GV to 3 TV with 90×10−6 helium, 8.4×10^{6} carbon, and 7.0×10 6} oxygen nuclei collected by the Alpha Magnetic Spectrometer (AMS) during the first five years of operation are reported.
Abstract: We report the observation of new properties of primary cosmic rays He, C, and O measured in the rigidity (momentum/charge) range 2 GV to 3 TV with 90×106 helium, 8.4×106 carbon, and 7.0×106 oxygen nuclei collected by the Alpha Magnetic Spectrometer (AMS) during the first five years of operation. Above 60 GV, these three spectra have identical rigidity dependence. They all deviate from a single power law above 200 GV and harden in an identical way.

Journal ArticleDOI
TL;DR: The data suggest that circRNA serves as a microRNA “sponge” to regulate the molecular circuitry, which modulates human pluripotency and differentiation.
Abstract: Accumulating evidence indicates that circular RNAs (circRNAs) are abundant in the human transcriptome. However, their involvement in biological processes, including pluripotency, remains mostly undescribed. We identified a subset of circRNAs that are enriched in undifferentiated human embryonic stem cells (hESCs) and demonstrated that two, circBIRC6 and circCORO1C, are functionally associated with the pluripotent state. Mechanistically, we found that circBIRC6 is enriched in the AGO2 complex and directly interacts with microRNAs, miR-34a, and miR-145, which are known to modulate target genes that maintain pluripotency. Correspondingly, circBIRC6 attenuates the downregulation of these target genes and suppresses hESC differentiation. We further identified hESC-enriched splicing factors (SFs) and demonstrated that circBIRC6 biogenesis in hESCs is promoted by the SF ESRP1, whose expression is controlled by the core pluripotency-associated factors, OCT4 and NANOG. Collectively, our data suggest that circRNA serves as a microRNA "sponge" to regulate the molecular circuitry, which modulates human pluripotency and differentiation.

Journal ArticleDOI
TL;DR: In this paper, the authors summarize recent developments on acidity characterization of solid and liquid catalysts by means of experimental 31P nuclear magnetic resonance (NMR) spectroscopy using phosphorus probe molecules such as trialkylphosphin.
Abstract: Acid–base catalytic reaction, either in heterogeneous or homogeneous systems, is one of the most important chemical reactions that has provoked a wide variety of industrial catalytic processes for production of chemicals and petrochemicals over the past few decades. In view of the fact that the catalytic performances (e.g., activity, selectivity, and reaction mechanism) of acid-catalyzed reactions over acidic catalysts are mostly dictated by detailed acidic features, viz. type (Bronsted vs Lewis acidity), amount (concentration), strength, and local environments (location) of acid sites, information on and manipulation of their structure–activity correlation are crucial for optimization of catalytic performances as well as innovative design of novel effective catalysts. This review aims to summarize recent developments on acidity characterization of solid and liquid catalysts by means of experimental 31P nuclear magnetic resonance (NMR) spectroscopy using phosphorus probe molecules such as trialkylphosphin...

Journal ArticleDOI
TL;DR: In this article, the authors make use of data from SDSS-IV, which was provided by the Alfred P. Sloan Foundation and Participating Institutions (SFS-IV).
Abstract: FB and RM acknowledge funding from the United Kingdom Science and Technology Facilities Council (STFC). RM acknowledges funding from the European Research Council (ERC), Advanced Grant 695671 ‘QUENCH’. SFS thanks the CONACYT- 125180, DGAPA-IA100815 and DGAPA-IA101217 projects for providing him support in this study. CAT acknowledges support from National Science Foundation of the United States grant 1412287 and 1554877. This work makes use of data from SDSS-IV. Funding for SDSS has been provided by the Alfred P. Sloan Foundation and Participating Institutions. Additional funding towards SDSS-IV has been provided by the U.S. Department of Energy Office of Science. SDSS-IV acknowledges support and resources from the Centre for High-Performance Computing at the University of Utah.

Journal ArticleDOI
TL;DR: The direct observation of the type II Weyl fermions in crystalline solid lanthanum aluminum germanide (LaAlGe) is presented based on photoemission data alone, without reliance on band structure calculations, and systematic data agree with the theoretical calculations, providing further support on the experimental results.
Abstract: In quantum field theory, Weyl fermions are relativistic particles that travel at the speed of light and strictly obey the celebrated Lorentz symmetry. Their low-energy condensed matter analogs are Weyl semimetals, which are conductors whose electronic excitations mimic the Weyl fermion equation of motion. Although the traditional (type I) emergent Weyl fermions observed in TaAs still approximately respect Lorentz symmetry, recently, the so-called type II Weyl semimetal has been proposed, where the emergent Weyl quasiparticles break the Lorentz symmetry so strongly that they cannot be smoothly connected to Lorentz symmetric Weyl particles. Despite some evidence of nontrivial surface states, the direct observation of the type II bulk Weyl fermions remains elusive. We present the direct observation of the type II Weyl fermions in crystalline solid lanthanum aluminum germanide (LaAlGe) based on our photoemission data alone, without reliance on band structure calculations. Moreover, our systematic data agree with the theoretical calculations, providing further support on our experimental results.

Proceedings ArticleDOI
20 Jun 2017
TL;DR: This paper develops fixation prediction networks that concurrently leverage sensor- and content-related features to predict the viewer fixation in the future, which is quite different from the solutions in the literature.
Abstract: We study the problem of predicting the Field-of-Views (FoVs) of viewers watching 360° videos using commodity Head-Mounted Displays (HMDs). Existing solutions either use the viewer's current orientation to approximate the FoVs in the future, or extrapolate future FoVs using the historical orientations and dead-reckoning algorithms. In this paper, we develop fixation prediction networks that concurrently leverage sensor- and content-related features to predict the viewer fixation in the future, which is quite different from the solutions in the literature. The sensor-related features include HMD orientations, while the content-related features include image saliency maps and motion maps. We build a 360° video streaming testbed to HMDs, and recruit twenty-five viewers to watch ten 360° videos. We then train and validate two design alternatives of our proposed networks, which allows us to identify the better-performing design with the optimal parameter settings. Trace-driven simulation results show the merits of our proposed fixation prediction networks compared to the existing solutions, including: (i) lower consumed bandwidth, (ii) shorter initial buffering time, and (iii) short running time.