Academia Sinica

About: Academia Sinica is a facility organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Gene. The organization has 52086 authors who have published 65998 publications receiving 1728114 citations. The organization is also known as: Central Research Academy.

Dualities and Representations of Lie Superalgebras

Abstract: This book gives a systematic account of the structure and representation theory of finite-dimensional complex Lie superalgebras of classical type and serves as a good introduction to representation theory of Lie superalgebras. Several folklore results are rigorously proved (and occasionally corrected in detail), sometimes with new proofs. Three important dualities are presented in the book, with the unifying theme of determining irreducible characters of Lie superalgebras. In order of increasing sophistication, they are Schur duality, Howe duality, and super duality. The combinatorics of symmetric functions is developed as needed in connections to Harish-Chandra homomorphism as well as irreducible characters for Lie superalgebras. Schur-Sergeev duality for the queer Lie superalgebra is presented from scratch with complete detail. Howe duality for Lie superalgebras is presented in book form for the first time. Super duality is a new approach developed in the past few years toward understanding the Bernstein-Gelfand-Gelfand category of modules for classical Lie superalgebras. Super duality relates the representation theory of classical Lie superalgebras directly to the representation theory of classical Lie algebras and thus gives a solution to the irreducible character problem of Lie superalgebras via the Kazhdan-Lusztig polynomials of classical Lie algebras.

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor.

Abstract: TDP-43, recently identified as a signature protein of the pathogenic inclusions in the brains cells of frontotemporal lobar degeneration patients, is a 43 kDa RNA-binding protein. It has been known mainly as a nuclear factor capable of repressing transcription and promoting exon exclusion. TDP-43 also forms distinct nuclear substructures linking different types of nuclear bodies. In this study, we provide the first evidence supporting TDP-43 as a neuronal activity-responsive factor in the dendrites of hippocampal neurons. In particular, TDP-43 resides in the somatodendrites mainly in the form of RNA granules colocalized with the post-synaptic protein PSD-95. These granules also contain RNAs including at least the β-actin mRNA and CaMKIIα mRNA. Furthermore, TDP-43 is localized in the dendritic processing (P) body and it behaves as a translational repressor in an in vitro assay. Related to this, repetitive stimuli by KCl greatly enhance the colocalization of TDP-43 granules with FMRP and Staufen 1, two RNA-binding proteins known to regulate mRNA transport and local translation in neurons. These data together suggest that TDP-43 is a neuronal activity-responsive factor functioning in the regulation of neuronal plasticity, the impairment of which would lead to the development of certain forms of neurodegenerative diseases including frontotemporal lobar degeneration.