Institution
Academia Sinica
Facility•Taipei, Taiwan•
About: Academia Sinica is a facility organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Gene. The organization has 52086 authors who have published 65998 publications receiving 1728114 citations. The organization is also known as: Central Research Academy.
Topics: Population, Gene, Galaxy, Catalysis, Large Hadron Collider
Papers published on a yearly basis
Papers
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TL;DR: Combined database analysis and cDNA cloning have demonstrated that the primary transcript of the mammalian TDP genes undergoes alternative splicing to generate 11 mRNAs, including the one encoding TDP-43, which provides further support for the functional complexity of the eukaryotic T DP genes.
305 citations
TL;DR: The performance of the ATLAS muon reconstruction during the LHC run withpp collisions at s=7–8 TeV in 2011–2012 is presented, focusing mainly on data collected in 2012.
Abstract: This paper presents the performance of the ATLAS muon reconstruction during the LHC run with pp collisions at root s = 7-8 TeV in 2011-2012, focusing mainly on data collected in 2012. Measurements ...
305 citations
TL;DR: This multiancestry study recommends investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G 6PD deficiency is common, and investigates the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance.
Abstract: Background: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identif ...
304 citations
University of Milan1, INAF2, Aix-Marseille University3, Roma Tre University4, University of Nice Sophia Antipolis5, University of Geneva6, Academia Sinica7, University of Bologna8, University of Edinburgh9, Institut d'Astrophysique de Paris10, Jan Kochanowski University11, Nagoya University12, Jagiellonian University13, Max Planck Society14, University of Portsmouth15
TL;DR: The VIMOS Public Extragalactic Redshift Survey (VIPERS) as discussed by the authors was designed to address a broad range of problems in large-scale structure and galaxy evolution, thanks to a unique combination of volume and sampling rate, comparable to state-of-the-art surveys of the local Universe, together with extensive multi-band optical and near-infrared photometry.
Abstract: We describe the construction and general features of VIPERS, the VIMOS Public Extragalactic Redshift Survey. This `Large Programme' has been using the ESO VLT with the aim of building a spectroscopic sample of ~100,000 galaxies with i_{AB}<22.5 and 0.5
304 citations
TL;DR: The result that arsenite at low concentrations increases oxidant levels and causes oxidative DNA damage in vascular smooth muscle cells may be important in arsenic-induced atherosclerosis.
Abstract: Arsenic is atherogenic, carcinogenic, and genotoxic. Because atherosclerotic plaque has been considered a benign smooth muscle cell tumor, we have studied the effects of arsenite on DNA integrity of human vascular smooth muscle cells. By using single-cell alkaline electrophoresis, apparent DNA strand breaks were detected in a 4-hour treatment with arsenite at a concentration above 1 micromol/L. DNA strand breaks of arsenite-treated cells were increased by Escherichia coli formamidopyrimidine-DNA glycosylase and decreased by diphenylene iodinium, superoxide dismutase, catalase, pyruvate, DMSO, or D-mannitol. Extract from arsenite-treated cells showed increased capacity for producing superoxide when NADH was included in the reaction mixture; however, addition of arsenite to extract from untreated cells did not increase superoxide production. The superoxide-producing ability of arsenite-treated cells was also suppressed by diphenylene iodinium, 4,5-dihydroxy-1, 2-benzenedisulfonic acid disodium salt (Tiron), or superoxide dismutase. Superoxide production and DNA strand breaks in arsenite-treated cells were also suppressed by transfecting antisense oligonucleotides of p22phox, an essential component of NADH oxidase. Treatment with arsenite also increased the mRNA level of p22phox. These results suggest that arsenite activates NADH oxidase to produce superoxide, which then causes oxidative DNA damage. The result that arsenite at low concentrations increases oxidant levels and causes oxidative DNA damage in vascular smooth muscle cells may be important in arsenic-induced atherosclerosis.
304 citations
Authors
Showing all 52129 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Yi Chen | 217 | 4342 | 293080 |
| Jing Wang | 184 | 4046 | 202769 |
| Jie Zhang | 178 | 4857 | 221720 |
| Hyun-Chul Kim | 176 | 4076 | 183227 |
| Yang Yang | 164 | 2704 | 144071 |
| Yuh Nung Jan | 162 | 460 | 74818 |
| Jongmin Lee | 150 | 2257 | 134772 |
| Hui-Ming Cheng | 147 | 880 | 111921 |
| Teruki Kamon | 142 | 2034 | 115633 |
| Jian Yang | 142 | 1818 | 111166 |
| I. V. Gorelov | 139 | 1916 | 103133 |
| S. R. Hou | 139 | 1845 | 106563 |
| Kaori Maeshima | 139 | 1850 | 105218 |
| Jiangyong Jia | 138 | 1173 | 91163 |
| Kenneth Bloom | 138 | 1958 | 110129 |