Institution
Academia Sinica
Facility•Taipei, Taiwan•
About: Academia Sinica is a facility organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Gene. The organization has 52086 authors who have published 65998 publications receiving 1728114 citations. The organization is also known as: Central Research Academy.
Topics: Population, Gene, Galaxy, Catalysis, Large Hadron Collider
Papers published on a yearly basis
Papers
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TL;DR: A simple-to-use risk score that uses baseline clinical variables was developed and validated and accurately estimates the risk of developing HCC at 3, 5, and 10 years in patients with chronic hepatitis B.
Abstract: Summary Background Therapy for chronic hepatitis B reduces the risk of progressing to hepatocellular carcinoma (HCC); however, there is no suitable and accurate means to assess risk. This study aimed to develop and validate a simple scoring system to predict HCC risk in patients with chronic hepatitis B. Methods The development cohort consisted of 3584 patients without cirrhosis from the community-based Taiwanese REVEAL-HBV study (of whom 131 developed HCC during follow-up), and a validation cohort of 1505 patients from three hospitals in Hong Kong and South Korea (of whom 111 developed HCC during follow-up). We used Cox multivariate proportional hazards model to predict risk of HCC at 3, 5, and 10 years. Variables included in the risk score were sex, age, serum alanine aminotransferase concentration, HBeAg status, and serum HBV DNA level. We calculated the area under receiver operating curve (AUROC) and calibration of predicted and observed HCC risk. Findings A 17-point risk score was developed, with HCC risk ranging from 0·0% to 23·6% at 3 years, 0·0% to 47·4% at 5 years, and 0·0% to 81·6% at 10 years for patients with the lowest and highest HCC risk, respectively. AUROCs to predict risk were 0·811 (95% CI 0·790–0·831) at 3 years, 0·796 (0·775–0·816) at 5 years, and 0·769 (0·747–0·790) at 10 years in the validation cohort, and 0·902 (0·884–0·918), 0·783 (0·759–0·806), and 0·806 (0·783–0·828), respectively, after exclusion of 277 patients in the validation cohort with cirrhosis. Predicted risk was well calibrated with Kaplan-Meier observed HCC risk. Interpretation A simple-to-use risk score that uses baseline clinical variables was developed and validated. The score accurately estimates the risk of developing HCC at 3, 5, and 10 years in patients with chronic hepatitis B. Clinicians can use this score to assess risk of HCC in patients with chronic hepatitis B and subsequently make evidence-based decisions about their clinical management. Funding The Academia Sinica; the National Health Research Institute, Taiwan; and Bristol-Myers Squibb.
532 citations
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TL;DR: Much still needs to be done to gain better understanding of in vivo biological function, 3-D structure, how this group of enzymes evolved to utilize many different substrates, and the mechanism of reactions, as well as understanding the conformational changes.
529 citations
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TL;DR: In this paper, the authors show that the Gibbs free energy for atomic hydrogen adsorption (ΔG0H) on MoSe2 edges is closer to thermoneutral than that on MoS2, with an H coverage of about 75% on the edge under operating conditions.
Abstract: MoSe2 nanosheets and MoSe2/graphene hybrids have been prepared by a facile hydrothermal method. The number of layers of the MoSe2 nanosheets is typically <10 as confirmed directly by transmission electron microscopy and indirectly by a red shift of the characteristic A1g Raman peak. The hydrogen evolution reaction (HER) studies show that the onset potentials of MoSe2 and MoSe2/RGO hybrids are only ∼0.15 V vs. RHE and ∼0.05 V vs. RHE, respectively, about 20–30 mV lower than those of MoS2 and its graphene hybrids reported previously. Density functional theory calculations reveal that the Gibbs free energy for atomic hydrogen adsorption (ΔG0H) on MoSe2 edges is closer to thermoneutral than that on MoS2, with an H coverage of about 75% on the edge under operating conditions, which is also higher than that of MoS2 reported in the literature. The consistency between the experimental and computational results indicates that MoSe2 nanosheets have potential to be a better HER catalyst than their MoS2 counterpart.
528 citations
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Ehime University1, Tulane University2, National University of Singapore3, Singapore National Eye Center4, Academia Sinica5, China Medical University (Taiwan)6, Shanghai Jiao Tong University7, Kyushu University8, Osaka University9, Aichi Gakuin University10, Shimane University11, Peking Union Medical College12, Chinese National Human Genome Center13, Mukogawa Women's University14, Nagoya University15, National Institutes of Health16, University of California, San Francisco17, University of Texas at Austin18, Tsinghua University19, Agency for Science, Technology and Research20, Washington University in St. Louis21, University of Melbourne22
TL;DR: A meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry followed up with de novo genotyping and further replication in east Asian samples provides new insights into blood pressure regulation and potential targets for intervention.
Abstract: We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10(-31) and P = 1.3 × 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.
527 citations
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TL;DR: The results indicated that the ability of those compounds to protect synaptosomes from the damage of lipid peroxidation initiated by Fe2+/Fe3+ was dependent not only on their iron-chelating activity and free-radical scavenging activity, but also on the stability of their semiquinone free radicals.
527 citations
Authors
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Name | H-index | Papers | Citations |
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Yi Chen | 217 | 4342 | 293080 |
Jing Wang | 184 | 4046 | 202769 |
Jie Zhang | 178 | 4857 | 221720 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Yang Yang | 164 | 2704 | 144071 |
Yuh Nung Jan | 162 | 460 | 74818 |
Jongmin Lee | 150 | 2257 | 134772 |
Hui-Ming Cheng | 147 | 880 | 111921 |
Teruki Kamon | 142 | 2034 | 115633 |
Jian Yang | 142 | 1818 | 111166 |
I. V. Gorelov | 139 | 1916 | 103133 |
S. R. Hou | 139 | 1845 | 106563 |
Kaori Maeshima | 139 | 1850 | 105218 |
Jiangyong Jia | 138 | 1173 | 91163 |
Kenneth Bloom | 138 | 1958 | 110129 |